Measurement of pressure and assessment of cavitation for a 22.5-kHz intra-arterial angioplasty device

This study was performed to understand better the mechanisms of action of an (22.5 kHz) ultrasonic wire catheter device used to remove atheromatous plaque in diseased blood vessels (ultrasonic angioplasty). During a clinical procedure, the wire acts as an acoustic waveguide to transfer acoustic energy from a generator outside the body to the ball tip of the wire, which is inserted in the blood vessel. The acoustic field radiated by the vibrating ball tip (1.5- to 3.0-mm diameter), was mapped in a relatively large (600 L) water tank and compared to the field from a well-characterized simple source. A dipolelike radiation pattern due to the translating ball tip was observed. At low power settings, standing wave effects in a smaller cylindrical volume (200-mm diameter, 350-mm height), which was used to simulate anthropometric dimensions, increase relative to the larger tank measurements. The standing wave ratio is dependent upon the pc characteristics of the medium and the dimensions of the volume, rather than on the absorption at this frequency. At high power-settings of the device, cavitation at the tip of the wire was measured using a 20-MHz passive cavitation detection scheme

Nanogratings Formation in a System of Ultra-short Laser Pulses – Metalloorganic Gas – Deposited Metal – Sapphire in Sinergetic Interference Field with Waveguide Modes Participation

Experimental results of laser-induced deposition of structured metal films from metalloorganic vapor have been analyzed. A new physical model has been put forward to explain the results. The model is based on the interference phenomena between the incident laser radiation and waveguide modes of a thermally induced gradient waveguide in the substrate. Keywords: femtosecond radiation, metal deposition, interference, waveguide modes, surface nanogratings

Dissociating between object affordances and spatial compatibility effects using early response components

Perception and action are tightly linked: objects may be perceived not only in terms of visual features, but also in terms of possibilities for action. Previous studies showed that when a centrally located object has a salient graspable feature (e.g., a handle), it facilitates motor responses corresponding with the feature's position. However, such so-called affordance effects have been criticized as resulting from spatial compatibility effects, due to the visual asymmetry created by the graspable feature, irrespective of any affordances. In order to dissociate between affordance and spatial compatibility effects, we asked participants to perform a simple reaction-time task to typically graspable and non-graspable objects with similar visual features (e.g., lollipop and stop sign). Responses were measured using either electromyography (EMG) on proximal arm muscles during reaching-like movements, or with finger key-presses. In both EMG and button press measurements, participants responded faster when the object was either presented in the same location as the responding hand, or was affordable, resulting in significant and independent spatial compatibility and affordance effects, but no interaction. Furthermore, while the spatial compatibility effect was present from the earliest stages of movement preparation and throughout the different stages of movement execution, the affordance effect was restricted to the early stages of movement execution. Finally, we tested a small group of unilateral arm amputees using EMG, and found residual spatial compatibility but no affordance, suggesting that spatial compatibility effects do not necessarily rely on individuals’ available affordances. Our results show dissociation between affordance and spatial compatibility effects, and suggest that rather than evoking the specific motor action most suitable for interaction with the viewed object, graspable objects prompt the motor system in a general, body-part independent fashio

Brain (re)organisation following amputation:implications for phantom limb pain

Following arm amputation the region that represented the missing hand in primary somatosensory cortex (S1) becomes deprived of its primary input, resulting in changed boundaries of the S1 body map. This remapping process has been termed ‘reorganisation’ and has been attributed to multiple mechanisms, including increased expression of previously masked inputs. In a maladaptive plasticity model, such reorganisation has been associated with phantom limb pain (PLP). Brain activity associated with phantom hand movements is also correlated with PLP, suggesting that preserved limb functional representation may serve as a complementary process. Here we review some of the most recent evidence for the potential drivers and consequences of brain (re)organisation following amputation, based on human neuroimaging. We emphasise other perceptual and behavioural factors consequential to arm amputation, such as non-painful phantom sensations, perceived limb ownership, intact hand compensatory behaviour or prosthesis use, which have also been related to both cortical changes and PLP. We also discuss new findings based on interventions designed to alter the brain representation of the phantom limb, including augmented/virtual reality applications and brain computer interfaces. These studies point to a close interaction of sensory changes and alterations in brain regions involved in body representation, pain processing and motor control. Finally, we review recent evidence based on methodological advances such as high field neuroimaging and multivariate techniques that provide new opportunities to interrogate somatosensory representations in the missing hand cortical territory. Collectively, this research highlights the need to consider potential contributions of additional brain mechanisms, beyond S1 remapping, and the dynamic interplay of contextual factors with brain changes for understanding and alleviating PLP

Analisis Pertumbuhan dan Perkembangan Biji Pala (Myristica fragrans Houtt.)

Tidak diijinkan karya tersebut diunggah ke dalam aplikasi Repositori Perpustakaan Universitas.Tujuan penelitian adalah mempelajari pola pertumbuhan dan perkembangan biji pala (Myristica fragrans Houtt.). Parameter yang dipakai adalah diameter, berat basah, berat kering, dan tampilan biji. Buah pala dipetik dengan berbagai ukuran dan dikelompokan sebanyak dua kali berdasarkan diameter buah, diameter biji, warna kulit buah, warna tempurung biji, dan warna fuli. Hasil penelitian berdasarakan pengukuran diameteter, berat basah, dan berat kering biji menunjukan pola pertumbuhan dan perkembangan biji pala berbentuk sigmoid dan umur biji pala diketahui. Biji yang paling muda diketahui memasuki usia minggu ke-3 dan biji paling tua memasuki usia minggu ke-36. Biji pala mengalami perubahan ukuran dan warna dalam setiap tahap perkembangannya.The aim of this research is to study the growth pattern and development of the nutmeg seed (Myristica fragrans Houtt). The parameters used were diameter, wet weight, dry weight, and seed appearance. Various sizes of nutmeg were picked and grouped twice by fruit diameter, seed diameter, fruit skin color, shell color, and mace color. The results of the study based on the diameter, wet weight, and dry weight of seed showed growth patterns and development of sigmoid shaped nutmeg seed and the nutmeg seed age was known. The youngest seed is known to enter its 3rd week of age and the oldest seed was entering the age of week 36. The nutmeg seed experienced changes in size and color in every stage of its development

Developing effective institutions for water resources management: A case study in the Deduru Oya Basin, Sri Lanka

River basins / Water resource management / Water lifting / Wells / Domestic water / Population / Economic aspects / Income / Irrigation programs / Institutions / Policy / Groundwater / Agricultural development / Fish farming / Pumps / Ecology / Water supply / Drought / Poverty / Land use / Water scarcity / Natural resources / Agricultural production / Cropping systems

Analytic solutions of the 1D finite coupling delta function Bose gas

An intensive study for both the weak coupling and strong coupling limits of the ground state properties of this classic system is presented. Detailed results for specific values of finite $N$ are given and from them results for general $N$ are determined. We focus on the density matrix and concomitantly its Fourier transform, the occupation numbers, along with the pair correlation function and concomitantly its Fourier transform, the structure factor. These are the signature quantities of the Bose gas. One specific result is that for weak coupling a rational polynomial structure holds despite the transcendental nature of the Bethe equations. All these new results are predicated on the Bethe ansatz and are built upon the seminal works of the past.Comment: 23 pages, 0 figures, uses rotate.sty. A few lines added. Accepted by Phys. Rev.

Topotecan-vincristine-doxorubicin in stage 4 high risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC : a SIOPEN study

Purpose : Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response (CR) or partial response (PR) with <= three abnormal skeletal areas on iodine 123-metaiodobenzylguanidine ([I-123] mIBG) scintigraphy and no bone marrow disease proceed to high dose therapy (HDT). In this study, topotecan-vincristine-doxorubicin (TVD) was evaluated in patients failing to achieve these criteria, with the aim of improving the metastatic response rate. Materials and Methods : Patients with metastatic high-risk neuroblastoma who had not achieved the SIOPEN criteria for HDT after induction received two courses of topotecan 1.5 mg/m(2)/day for 5 days, followed by a 48-hour infusion of vincristine, 2 mg/m(2), and doxorubicin, 45 mg/m(2). Results : Sixty-three patients were eligible and evaluable. Following two courses of TVD, four (6.4%) patients had an overall CR, while 28 (44.4%) had a PR with a combined response rate of 50.8% (95% confidence interval [CI], 37.9 to 63.6). Of these, 23 patients achieved a metastatic CR or a PR with <= 3 mIBG skeletal areas and no bone marrow disease (36.5%; 95% CI, 24.7 to 49.6) and were eligible to receive HDT. Toxicity was mostly haematological, affecting 106 of the 126 courses (84.1%; 95% CI, 76.5 to 90.0), and dose reduction was necessary in six patients. Stomatitis was the second most common nonhematological toxicity, occurring in 20 patients (31.7%). Conclusion : TVD was effective in improving the response rate of high-risk neuroblastoma patients after induction with COJEC enabling them to proceed to HDT. However, the long-term benefits of TVD needs to be determined in randomized clinical trials

Motor control drives visual bodily judgements

The ‘embodied cognition’ framework proposes that our motor repertoire shapes visual perception and cognition. But recent studies showing normal visual body representation in individuals born without hands challenges the contribution of motor control on visual body representation. Here, we studied hand laterality judgements in three groups with fundamentally different visual and motor hand experiences: two-handed controls, one-handers born without a hand (congenital one-handers) and one-handers with an acquired amputation (amputees). Congenital one-handers, lacking both motor and first-person visual information of their missing hand, diverged in their performance from the other groups, exhibiting more errors for their intact hand and slower reaction-times for challenging hand postures. Amputees, who have lingering non-visual motor control of their missing (phantom) hand, performed the task similarly to controls. Amputees’ reaction-times for visual laterality judgements correlated positively with their phantom hand’s motor control, such that deteriorated motor control associated with slower visual laterality judgements. Finally, we have implemented a computational simulation to describe how a mechanism that utilises a single hand representation in congenital one-handers as opposed to two in controls, could replicate our empirical results. Together, our findings demonstrate that motor control is a driver in making visual bodily judgments

Peripersonal space: a multisensory interface for body-object interactions

Research in the last four decades has brought a considerable advance in our understanding of how the brain synthesizes information arising from different sensory modalities. Indeed, many cortical and subcortical areas, beyond those traditionally considered to be ‘associative,’ have been shown to be involved in multisensory interaction and integration (Ghazanfar and Schroeder 2006). Visuo-tactile interaction is of particular interest, because of the prominent role played by vision in guiding our actions and anticipating their tactile consequences in everyday life. In this chapter, we focus on the functional role that visuo-tactile processing may play in driving two types of body-object interactions: avoidance and approach. We will first review some basic features of visuo-tactile interactions, as revealed by electrophysiological studies in monkeys. These will prove to be relevant for interpreting the subsequent evidence arising from human studies. A crucial point that will be stressed is that these visuo-tactile mechanisms have not only sensory, but also motor-related activity that qualifies them as multisensory-motor interfaces. Evidence will then be presented for the existence of functionally homologous processing in the human brain, both from neuropsychological research in brain-damaged patients and in healthy participants. The final part of the chapter will focus on some recent studies in humans showing that the human motor system is provided with a multisensory interface that allows for continuous monitoring of the space near the body (i.e., peripersonal space). We further demonstrate that multisensory processing can be modulated on-line as a consequence of interacting with objects. This indicates that, far from being passive, the monitoring of peripersonal space is an active process subserving actions between our body and objects located in the space around us