The 2015 Sheffield System for Longitudinal Diarisation of Broadcast Media

Speaker diarisation is the task of answering "who spoke when" within a multi-speaker audio recording. Diarisation of broadcast media typically operates on individual television shows, and is a particularly difficult task, due to a high number of speakers and challenging background conditions. Using prior knowledge, such as that from previous shows in a series, can improve performance. Longitudinal diarisation allows to use knowledge from previous audio files to improve performance, but requires finding matching speakers across consecutive files. This paper describes the University of Sheffield system for participation in the 2015 Multi-Genre Broadcast (MGB) challenge. The challenge required longitudinal diarisation of data from BBC archives, under very constrained resource settings. Our system consists of three main stages: speech activity detection using DNNs with novel adaptation and decoding methods; speaker segmentation and clustering, with adaptation of the DNN-based clustering models; and finally speaker linking to match speakers across shows. The final result on the development set of 19 shows from five different television series provided a Diarisation Error Rate of 50.77% in the diarisation and linking task

Evidence-based planning and costing palliative care services for children : novel multi-method epidemiological and economic exemplar

Background: Children’s palliative care is a relatively new clinical specialty. Its nature is multi-dimensional and its delivery necessarily multi-professional. Numerous diverse public and not-for-profit organisations typically provide services and support. Because services are not centrally coordinated, they are provided in a manner that is inconsistent and incoherent. Since the first children’s hospice opened in 1982, the epidemiology of life-limiting conditions has changed with more children living longer, and many requiring transfer to adult services. Very little is known about the number of children living within any given geographical locality, costs of care, or experiences of children with ongoing palliative care needs and their families. We integrated evidence, and undertook and used novel methodological epidemiological work to develop the first evidence-based and costed commissioning exemplar. Methods: Multi-method epidemiological and economic exemplar from a health and not-for-profit organisation perspective, to estimate numbers of children under 19 years with life-limiting conditions, cost current services, determine child/parent care preferences, and cost choice of end-of-life care at home. Results: The exemplar locality (North Wales) had important gaps in service provision and the clinical network. The estimated annual total cost of current children’s palliative care was about £5.5 million; average annual care cost per child was £22,771 using 2007 prevalence estimates and £2,437- £11,045 using new 2012/13 population-based prevalence estimates. Using population-based prevalence, we estimate 2271 children with a life-limiting condition in the general exemplar population and around 501 children per year with ongoing palliative care needs in contact with hospital services. Around 24 children with a wide range of life-limiting conditions require end-of-life care per year. Choice of end-of-life care at home was requested, which is not currently universally available. We estimated a minimum (based on 1 week of end-of-life care) additional cost of £336,000 per year to provide end-of-life support at home. Were end-of-life care to span 4 weeks, the total annual additional costs increases to £536,500 (2010/11 prices). Conclusions: Findings make a significant contribution to population-based needs assessment and commissioning methodology in children’s palliative care. Further work is needed to determine with greater precision which children in the total population require access to services and when. Half of children who died 2002-7 did not have conditions that met the globally used children's palliative care condition categories, which need revision in light of findings

The 2015 Sheffield System for Transcription of Multi–Genre Broadcast Media

We describe the University of Sheffield system for participation in the 2015 Multi-Genre Broadcast (MGB) challenge task of transcribing multi-genre broadcast shows. Transcription was one of four tasks proposed in the MGB challenge, with the aim of advancing the state of the art of automatic speech recognition, speaker diarisation and automatic alignment of subtitles for broadcast media. Four topics are investigated in this work: Data selection techniques for training with unreliable data, automatic speech segmentation of broadcast media shows, acoustic modelling and adaptation in highly variable environments, and language modelling of multi-genre shows. The final system operates in multiple passes, using an initial unadapted decoding stage to refine segmentation, followed by three adapted passes: a hybrid DNN pass with input features normalised by speaker-based cepstral normalisation, another hybrid stage with input features normalised by speaker feature-MLLR transformations, and finally a bottleneck-based tandem stage with noise and speaker factorisation. The combination of these three system outputs provides a final error rate of 27.5% on the official development set, consisting of 47 multi-genre shows

Genomic analysis of clostridioides difficile recovered from horses in Western Australia

Clostridioides difficile poses an ongoing threat as a cause of gastrointestinal disease in humans and animals. Traditionally considered a human healthcare-related disease, increases in community-associated C. difficile infection (CDI) and growing evidence of inter-species transmission suggest a wider perspective is required for CDI control. In horses, C. difficile is a major cause of diarrhoea and life-threatening colitis. This study aimed to better understand the epidemiology of CDI in Australian horses and provide insights into the relationships between horse, human and environmental strains. A total of 752 faecal samples from 387 Western Australian horses were collected. C. difficile was isolated from 104 (30.9%) horses without gastrointestinal signs and 19 (37.8%) with gastrointestinal signs. Of these, 68 (55.3%) harboured one or more toxigenic strains, including C. difficile PCR ribotypes (RTs) 012 (n = 14), 014/020 (n = 10) and 087 (n = 7), all prominent in human infection. Whole-genome analysis of 45 strains identified a phylogenetic cluster of 10 closely related C. difficile RT 012 strains of equine, human and environmental origin (0–62 SNP differences; average 23), indicating recent shared ancestry. Evidence of possible clonal inter-species transmission or common-source exposure was identified for a subgroup of three horse and one human isolates, highlighting the need for a One Health approach to C. difficile surveillance

Fluorodeoxyglucose positron emission tomography in the evaluation of germ cell tumours at relapse

Differentiation of active disease from fibrosis/mature teratoma in patients with residual masses or identifying of sites of recurrence in patients with raised markers following treatment of their testicular cancer remains a problem.18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has the potential to identify active disease and thereby influence further management in these patients. We performed a retrospective study of the use of FDG-PET in detecting residual/recurrent testicular carcinoma in 55 patients (seventy FDG-PET scans). Forty-seven scans were for the assessment of residual masses (18 had raised markers) and 23 scans were for the investigation of raised markers in the presence of normal CT scans. True positive results were based on positive histology or clinical follow-up. FDG-PET had a positive predictive value (PPV) of 96% and a negative predictive value (NPV) of 90% in patients with residual masses. This PPV was equivalent to that of markers (94%) but FDG-PET had the advantage of identifying the site of that recurrence. The NPV was higher than that of markers. In patients with raised markers alone the PPV of FDG-PET was 92% but the NPV was only 50%. However, subsequent FDG-PET imaging was frequently the first imaging modality to identify the site of disease. FDG-PET effected a management change in 57% of cases. FDG-PET scanning detected viable tumour in residual masses and identified sites of disease in suspected recurrence. © 2000 Cancer Research Campaig

Complete genome sequences of evolutionary clade C-III strains of Clostridioides (Clostridium) difficile isolated from the environment in Western Australia

Clostridioides (Clostridium) difficile in the environment is thought to contribute to C. difficile infection in community settings. Here, we provide complete genome assemblies for two esculin hydrolysis-negative strains of C. difficile that were isolated from soils in Western Australia; the strains produce white colonies on chromogenic media and belong to evolutionarily divergent clade C-III

Bioinspired Autonomous Visual Vertical Control of a Quadrotor Unmanned Aerial Vehicle

Near-ground maneuvers, such as hover, approach, and landing, are key elements of autonomy in unmanned aerial vehicles. Such maneuvers have been tackled conventionally by measuring or estimating the velocity and the height above the ground, often using ultrasonic or laser range finders. Near-ground maneuvers are naturally mastered by flying birds and insects because objects below may be of interest for food or shelter. These animals perform such maneuvers efficiently using only the available vision and vestibular sensory information. In this paper, the time-to-contact (tau) theory, which conceptualizes the visual strategy with which many species are believed to approach objects, is presented as a solution for relative ground distance control for unmanned aerial vehicles. The paper shows how such an approach can be visually guided without knowledge of height and velocity relative to the ground. A control scheme that implements the tau strategy is developed employing only visual information from a monocular camera and an inertial measurement unit. To achieve reliable visual information at a high rate, a novel filtering system is proposed to complement the control system. The proposed system is implemented onboard an experimental quadrotor unmanned aerial vehicle and is shown to not only successfully land and approach ground, but also to enable the user to choose the dynamic characteristics of the approach. The methods presented in this paper are applicable to both aerial and space autonomous vehicles

Genome sequence of Listeria monocytogenes 2542, a serotype 4b strain from a cheese-related outbreak in Portugal

We report here the draft genome sequence of Listeria monocytogenes 2542, a serotype 4b clinical strain recovered from a placental sample during a cheese-related listeriosis outbreak in Portugal.Work done by T.C. and T.H. was supported by LOEWE Medical RNomics (B3) and theGermanCentre for Infection Research, Justus-Liebig University Giessen. Financial sup-port for R.M. and V.F. was provided by Fundação para a Ciência e a Tecnologia(FCT)through Ph.D. (SFRH/BD/71704/2010) and postdoctoral (SFRH/BPD/72617/2010) fellow-ships, respectively. Open-access publication was cofinanced by the NEWFOOD NORTE-01-0246-FEDER-000043 project supported by the Norte Portugal Regional OperationalProgramme (NORTE 2020), under the Portugal 2020 Partnership Agreement throughthe European Regional Development Fund (ERDF). We also acknowledge the scientificcollaboration under the FCT project UID/Multi/50016/2013

The USFD Spoken Language Translation System for IWSLT 2014

The University of Sheffield (USFD) participated in the International Workshop for Spoken Language Translation (IWSLT) in 2014. In this paper, we will introduce the USFD SLT system for IWSLT. Automatic speech recognition (ASR) is achieved by two multi-pass deep neural network systems with adaptation and rescoring techniques. Machine translation (MT) is achieved by a phrase-based system. The USFD primary system incorporates state-of-the-art ASR and MT techniques and gives a BLEU score of 23.45 and 14.75 on the English-to-French and English-to-German speech-to-text translation task with the IWSLT 2014 data. The USFD contrastive systems explore the integration of ASR and MT by using a quality estimation system to rescore the ASR outputs, optimising towards better translation. This gives a further 0.54 and 0.26 BLEU improvement respectively on the IWSLT 2012 and 2014 evaluation data