Reliability and Validity of the Telephone-Based eHealth Literacy Scale Among Older Adults: Cross-Sectional Survey

Background: Only a handful of studies have examined reliability and validity evidence of scores produced by the 8-item eHealth literacy Scale (eHEALS) among older adults. Older adults are generally more comfortable responding to survey items when asked by a real person rather than by completing self-administered paper-and-pencil or online questionnaires. However, no studies have explored the psychometrics of this scale when administered to older adults over the telephone. Objective: The objective of our study was to examine the reliability and internal structure of eHEALS data collected from older adults aged 50 years or older responding to items over the telephone. Methods: Respondents (N=283) completed eHEALS as part of a cross-sectional landline telephone survey. Exploratory structural equation modeling (E-SEM) analyses examined model fit of eHEALS scores with 1-, 2-, and 3-factor structures. Subsequent analyses based on the partial credit model explored the internal structure of eHEALS data. Results: Compared with 1- and 2-factor models, the 3-factor eHEALS structure showed the best global E-SEM model fit indices (root mean square error of approximation=.07; comparative fit index=1.0; Tucker-Lewis index=1.0). Nonetheless, the 3 factors were highly correlated (r range .36 to .65). Item analyses revealed that eHEALS items 2 through 5 were overfit to a minor degree (mean square infit/outfit values <1.0; t statistics less than –2.0), but the internal structure of Likert scale response options functioned as expected. Overfitting eHEALS items (2-5) displayed a similar degree of information for respondents at similar points on the latent continuum. Test information curves suggested that eHEALS may capture more information about older adults at the higher end of the latent continuum (ie, those with high eHealth literacy) than at the lower end of the continuum (ie, those with low eHealth literacy). Item reliability (value=.92) and item separation (value=11.31) estimates indicated that eHEALS responses were reliable and stable. Conclusions: Results support administering eHEALS over the telephone when surveying older adults regarding their use of the Internet for health information. eHEALS scores best captured 3 factors (or subscales) to measure eHealth literacy in older adults; however, statistically significant correlations between these 3 factors suggest an overarching unidimensional structure with 3 underlying dimensions. As older adults continue to use the Internet more frequently to find and evaluate health information, it will be important to consider modifying the original eHEALS to adequately measure societal shifts in online health information seeking among aging populations.Open Access Fundin

Sternothyroideus myotomy, staphylectomy, and oral caudal soft palate photothermoplasty for treatment of dorsal displacement of the soft palate in 102 Thoroughbred racehorses. Veterinary Surgery 34

Abstract Sternothyroideus myotomy, staphylectomy, and soft palate thermoplasty are effective treatments for Thoroughbred racehorses suffering from the performance-limiting effects of dorsal displacement of the soft palate and offer similar performance outcomes as other surgical procedures

Northwest U.S. Agriculture in a Changing Climate: Collaboratively Defined Research and Extension Priorities

In order for agricultural systems to successfully mitigate and adapt to climate change there is a need to coordinate and prioritize next steps for research and extension. This includes focusing on “win-win” management practices that simultaneously provide short-term benefits to farmers and improve the sustainability and resiliency of agricultural systems with respect to climate change. In the Northwest U.S., a collaborative process has been used to engage individuals spanning the research-practice continuum. This collaborative approach was utilized at a 2016 workshop titled “Agriculture in a Changing Climate,” that included a broad range of participants including university faculty and students, crop and livestock producers, and individuals representing state, tribal and federal government agencies, industry, nonprofit organizations, and conservation districts. The Northwest U.S. encompasses a range of agro-ecological systems and diverse geographic and climatic contexts. Regional research and science communication efforts for climate change and agriculture have a strong history of engaging diverse stakeholders. These features of the Northwest U.S. provide a foundation for the collaborative research and extension prioritization presented here. We focus on identifying research and extension actions that can be taken over the next 5 years in four areas identified as important areas by conference organizers and participants: (1) cropping systems, (2) livestock systems, (3) decision support systems to support consideration of climate change in agricultural management decisions; and (4) partnerships among researchers and stakeholders. We couple insights from the workshop and a review of current literature to articulate current scientific understanding, and priorities recommended by workshop participants that target existing knowledge gaps, challenges, and opportunities. Priorities defined at the Agriculture in a Changing Climate workshop highlight the need for ongoing investment in interdisciplinary research integrating social, economic, and biophysical sciences, strategic collaborations, and knowledge sharing to develop actionable science that can support informed decision-making in the agriculture sector as the climate changes

Primate and Feline Lentivirus Vector RNA Packaging and Propagation by Heterologous Lentivirus Virions

Development of safe and effective gene transfer systems is critical to the success of gene therapy protocols for human diseases. Currently, several primate lentivirus-based gene transfer systems, such as those based on human and simian immunodeficiency viruses (HIV/SIV), are being tested; however, their use in humans raises safety concerns, such as the generation of replication-competent viruses through recombination with related endogenous retroviruses or retrovirus-like elements. Due to the greater phylogenetic distance from primate lentiviruses, feline immunodeficiency virus (FIV) is becoming the lentivirus of choice for human gene transfer systems. However, the safety of FIV-based vector systems has not been tested experimentally. Since lentiviruses such as HIV-1 and SIV have been shown to cross-package their RNA genomes, we tested the ability of FIV RNA to get cross-packaged into primate lentivirus particles such as HIV-1 and SIV, as well as a nonlentiviral retrovirus such as Mason-Pfizer monkey virus (MPMV), and vice versa. Our results reveal that FIV RNA can be cross-packaged by primate lentivirus particles such as HIV-1 and SIV and vice versa; however, a nonlentivirus particle such as MPMV is unable to package FIV RNA. Interestingly, FIV particles can package MPMV RNA but cannot propagate the vector RNA further for other steps of the retrovirus life cycle. These findings reveal that diverse retroviruses are functionally more similar than originally thought and suggest that upon coinfection of the same host, cross- or copackaging may allow distinct retroviruses to generate chimeric variants with unknown pathogenic potential