Simulations and performance of the QUBIC optical beam combiner

QUBIC, the Q & U Bolometric Interferometer for Cosmology, is a novel ground-based instrument that aims to measure the extremely faint B-mode polarisation anisotropy of the cosmic microwave background at intermediate angular scales (multipoles o

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals.

The threat to public health posed by drug-resistant bacteria is rapidly increasing, as some of healthcare\u27s most potent antibiotics are becoming obsolete. Approximately two-thirds of the world\u27s antibiotics are derived from natural products produced by Streptomyces encoded biosynthetic gene clusters. Thus, to identify novel gene clusters, we sequenced the genomes of four bioactive Streptomyces strains isolated from the soil in San Diego County and used Bacterial Cytological Profiling adapted for agar plate culturing in order to examine the mechanisms of bacterial inhibition exhibited by these strains. In the four strains, we identified 104 biosynthetic gene clusters. Some of these clusters were predicted to produce previously studied antibiotics; however, the known mechanisms of these molecules could not fully account for the antibacterial activity exhibited by the strains, suggesting that novel clusters might encode antibiotics. When assessed for their ability to inhibit the growth of clinically isolated pathogens, three Streptomyces strains demonstrated activity against methicillin-resistant Staphylococcus aureus. Additionally, due to the utility of bacteriophages for genetically manipulating bacterial strains via transduction, we also isolated four new phages (BartholomewSD, IceWarrior, Shawty, and TrvxScott) against S. platensis. A genomic analysis of our phages revealed nearly 200 uncharacterized proteins, including a new site-specific serine integrase that could prove to be a useful genetic tool. Sequence analysis of the Streptomyces strains identified CRISPR-Cas systems and specific spacer sequences that allowed us to predict phage host ranges. Ultimately, this study identified Streptomyces strains with the potential to produce novel chemical matter as well as integrase-encoding phages that could potentially be used to manipulate these strains

The QUBIC experiment

The Q & U Bolometric Interferometer for Cosmology (QUBIC) is a cosmology experiment which aims to measure the B-mode polarization of the Cosmic Microwave Background (CMB). Measurements of the primordial B-mode pattern of the CMB polarization is in fact among the most exciting goals in cosmology as it would allow testing the inflationary paradigm, an exponential expansion occurred during the first 10 1233 seconds of the Universe age. A large number of experiments are attempting to measure the B-modes, from the ground and from the stratosphere using classic imaging techniques. The QUBIC collaboration is developing an innovative concept to measure CMB polarization implementing bolometric interferometry which mixes the high sensitivity of bolometric detectors with an accurate systematics control due to the interferometric nature of the experiment. QUBIC is at an advanced state of tests on all sub-systems and we are planning to start with measurements by the end of 2018 from Alto Chorillo in Argentina

QUBIC: Exploring the Primordial Universe with the Q&U Bolometric Interferometer

In this paper, we describe QUBIC, an experiment that will observe the polarized microwave sky with a novel approach, which combines the sensitivity of state-of-the-art bolometric detectors with the systematic effects control typical of interferometers. QUBIC’s unique features are the so-called “self-calibration”, a technique that allows us to clean the measured data from instrumental effects, and its spectral imaging power, i.e., the ability to separate the signal into various sub-bands within each frequency band. QUBIC will observe the sky in two main frequency bands: 150 GHz and 220 GHz. A technological demonstrator is currently under testing and will be deployed in Argentina during 2019, while the final instrument is expected to be installed during 2020

Optical modelling and analysis of the Q and U bolometric interferometer for cosmology

Remnant radiation from the early universe, known as the Cosmic Microwave Background (CMB), has been redshifted and cooled, and today has a blackbody spectrum peaking at millimetre wavelengths. The QUBIC (Q&U Bolometric Interferometer for Cosmology) instrument is designed to map the very faint polaristion structure in the CMB. QUBIC is based on the novel concept of bolometric interferometry in conjunction with synthetic imaging. It will have a large array of input feedhorns, which creates a large number of interferometric baselines. The beam from each feedhorn is passed through an optical combiner, with an off-axis compensated Gregorian design, to allow the generation of the synthetic image. The optical-combiner will operate in two frequency bands (150 and 220 GHz with 25% and 18.2 % bandwidth respectively) while cryogenically cooled TES bolometers provide the sensitivity required at the image plane. The QUBIC Technical Demonstrator (TD), a proof of technology instrument that contains 64 input feed-horns, is currently being built and will be installed in the Alto Chorrillos region of Argentina. The plan is then for the full QUBIC instrument (400 feed-horns) to be deployed in Argentina and obtain cosmologically significant results. In this paper we will examine the output of the manufactered feed-horns in comparison to the nominal design. We will show the results of optical modelling that has been performed in anticipation of alignment and calibration of the TD in Paris, in particular testing the validity of real laboratory environments. We show the output of large calibrator sources (50 ° full width haf max Gaussian beams) and the importance of accurate mirror definitions when modelling large beams. Finally we describe the tolerance on errors of the position and orientation of mirrors in the optical combiner

QUBIC: the Q and U bolometric interferometer for cosmology

International audienc

QUBIC: measuring CMB polarization from Argentina

QUBIC (Q and U Bolometric Interferometer for Cosmology) is an ambitious project to measure the polarization of the Cosmic Microwave Background (CMB), which can provide unique information on the very early universe and the cosmic inflation process. The QUBIC instrument combines the extreme sensitivity of cryogenic bolometers and the accurate control of beam-forming and auto-calibration ability of interferometers. The instrument is being finalized and calibrated for a first installation at the Alto Chorrillo high altitude site (Salta province, Argentina) in late 2018, and will produce, in the first two years of operation, a sensitive measurement of CMB polarization, able to detect a tensor to scalar ratio for B-modes 0.01

Thermal architecture for the QUBIC cryogenic receiver

International audienceQUBIC, the QU Bolometric Interferometer for Cosmology, is a novel forthcoming instrument to measure the B-mode polarization anisotropy of the Cosmic Microwave Background. The detection of the B-mode signal will be extremely challenging; QUBIC has been designed to address this with a novel approach, namely bolometric interferometry. The receiver cryostat is exceptionally large and cools complex optical and detector stages to 40 K, 4 K, 1 K and 350 mK using two pulse tube coolers, a novel 4He sorption cooler and a double-stage 3He/4He sorption cooler. We discuss the thermal and mechanical design of the cryostat, modelling and thermal analysis, and laboratory cryogenic testing

Optical modelling and analysis of the Q and U bolometric interferometer for cosmology

International audienceRemnant radiation from the early universe, known as the Cosmic Microwave Background (CMB), has been redshifted and cooled, and today has a blackbody spectrum peaking at millimetre wavelengths. The QUBIC (Q&U Bolometric Interferometer for Cosmology) instrument is designed to map the very faint polaristion structure in the CMB. QUBIC is based on the novel concept of bolometric interferometry in conjunction with synthetic imaging. It will have a large array of input feedhorns, which creates a large number of interferometric baselines. The beam from each feedhorn is passed through an optical combiner, with an off-axis compensated Gregorian design, to allow the generation of the synthetic image. The optical-combiner will operate in two frequency bands (150 and 220 GHz with 25% and 18.2 % bandwidth respectively) while cryogenically cooled TES bolometers provide the sensitivity required at the image plane. The QUBIC Technical Demonstrator (TD), a proof of technology instrument that contains 64 input feed-horns, is currently being built and will be installed in the Alto Chorrillos region of Argentina. The plan is then for the full QUBIC instrument (400 feed-horns) to be deployed in Argentina and obtain cosmologically significant results. In this paper we will examine the output of the manufactered feed-horns in comparison to the nominal design. We will show the results of optical modelling that has been performed in anticipation of alignment and calibration of the TD in Paris, in particular testing the validity of real laboratory environments. We show the output of large calibrator sources (50 ° full width haf max Gaussian beams) and the importance of accurate mirror definitions when modelling large beams. Finally we describe the tolerance on errors of the position and orientation of mirrors in the optical combiner