The 11 May 2011 earthquake at Lorca (SE Spain) viewed in a structural-tectonic context

The Lorca earthquake of 11 May 2011 in the Betic Cordillera of SE Spain occurred almost exactly on the Alhama de Murcia fault, a marked fault that forms part of a NE-SW trending belt of faults and thrusts. The fault belt is reminiscent of a strike-slip corridor, but recent structural studies have provided clear evidence for reverse motions on these faults. Focal mechanisms of the main earthquake, but also of a foreshock, are strikingly consistent with structural observations on the Alhama de Murcia fault. This strengthens the conclusion that, rather than a strike-slip fault, the fault is at present a contractional fault with an oblique reverse sense of motion, presumably in response to the NW-directed motion of Africa with respect to Europe

Vibrational predissociation in the HCl dimer

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IRIS Burst Spectra Co-Spatial To A Quiet-Sun Ellerman-Like Brightening

Ellerman bombs (EBs) have been widely studied over the past two decades; however, only recently have counterparts of these events been observed in the quiet-Sun. The aim of this article is to further understand small-scale quiet-Sun Ellerman-like brightenings (QSEBs) through research into their spectral signatures, including investigating whether the hot signatures associated with some EBs are also visible co-spatial to any QSEBs. We combine H$\alpha$ and Ca II $8542$ \AA\ line scans at the solar limb with spectral and imaging data sampled by the Interface Region Imaging Spectrograph (IRIS). Twenty one QSEBs were identified with average lifetimes, lengths, and widths measured to be around $120$ s, $0.63$", and $0.35$", respectively. Three of these QSEBs displayed clear repetitive flaring through their lifetimes, comparable to the behaviour of EBs in Active Regions (ARs). Two QSEBs in this sample occurred co-spatial with increased emission in SDO/AIA $1600$ \AA\ and IRIS slit-jaw imager $1400$ \AA\ data, however, these intensity increases were smaller than reported co-spatial to EBs. One QSEB was also sampled by the IRIS slit during its lifetime, displaying increases in intensity in the Si IV $1393$ \AA\ and Si IV $1403$ \AA\ cores as well as the C II and Mg II line wings, analogous to IRIS bursts (IBs). Using RADYN simulations, we are unable to reproduce the observed QSEB H$\alpha$ and Ca II $8542$ \AA\ line profiles leaving the question of the temperature stratification of QSEBs open. Our results imply that some QSEBs could be heated to Transition Region temperatures, suggesting that IB profiles should be observed throughout the quiet-Sun

Complex chromosome 17p rearrangements associated with low-copy repeats in two patients with congenital anomalies

Recent molecular cytogenetic data have shown that the constitution of complex chromosome rearrangements (CCRs) may be more complicated than previously thought. The complicated nature of these rearrangements challenges the accurate delineation of the chromosomal breakpoints and mechanisms involved. Here, we report a molecular cytogenetic analysis of two patients with congenital anomalies and unbalanced de novo CCRs involving chromosome 17p using high-resolution array-based comparative genomic hybridization (array CGH) and fluorescent in situ hybridization (FISH). In the first patient, a 4-month-old boy with developmental delay, hypotonia, growth retardation, coronal synostosis, mild hypertelorism, and bilateral club feet, we found a duplication of the Charcot-Marie–Tooth disease type 1A and Smith-Magenis syndrome (SMS) chromosome regions, inverted insertion of the Miller-Dieker lissencephaly syndrome region into the SMS region, and two microdeletions including a terminal deletion of 17p. The latter, together with a duplication of 21q22.3-qter detected by array CGH, are likely the unbalanced product of a translocation t(17;21)(p13.3;q22.3). In the second patient, an 8-year-old girl with mental retardation, short stature, microcephaly and mild dysmorphic features, we identified four submicroscopic interspersed 17p duplications. All 17 breakpoints were examined in detail by FISH analysis. We found that four of the breakpoints mapped within known low-copy repeats (LCRs), including LCR17pA, middle SMS-REP/LCR17pB block, and LCR17pC. Our findings suggest that the LCR burden in proximal 17p may have stimulated the formation of these CCRs and, thus, that genome architectural features such as LCRs may have been instrumental in the generation of these CCRs

Suitability and managerial implications of a Master Surgical Scheduling approach

Abstract: Operating room (OR) planning and scheduling is a popular and challenging subject within the operational research applied to health services research (ORAHS). However, the impact in practice is very limited. The organization and culture of a hospital and the inherent characteristics of its processes impose specific implementation issues that affect the success of planning approaches. Current tactical OR planning approaches often fail to account for these issues.Master surgical scheduling (MSS) is a promising approach for hospitals to optimize resource utilization and patient flows. We discuss the pros and cons of MSS and compare MSS with centralized and decentralized planning approaches. Finally, we address various implementation issues of MSS and discuss its suitability for hospitals with different organizational foci and culture