The distance to the young cluster NGC 7129 and its age

The dust cloud TGU H645 P2 and embedded in it young open cluster NGC 7129 are investigated using the results of medium-band photometry of 159 stars in the Vilnius seven-colour system down to V = 18.8 mag. The photometric data were used to classify about 50 percent of the measured stars in spectral and luminosity classes. The extinction A_V vs. distance diagram for the 20x20 arcmin area is plotted for 155 stars with two-dimensional classification from the present and the previous catalogues. The extinction values found range between 0.6 and 3.4 mag. However, some red giants, located in the direction of the dense parts of the cloud, exhibit the infrared extinction equivalent up to A_V = 13 mag. The distance to the cloud (and the cluster) is found to be 1.15 kpc (the true distance modulus 10.30 mag). For determining the age of NGC 7129, a luminosity vs. temperature diagram for six cluster members of spectral classes B3 to A1 was compared with the Pisa pre-main-sequence evolution tracks and the Palla birthlines. The cluster can be as old as about 3 Myr, but star forming continues till now as witnessed by the presence in the cloud of many younger pre-main-sequence objects identified with photometry from 2MASS, Spitzer and WISE infrared surveys.Comment: 8 pages, 6 fugures, full Table 1 online. Accepted for publication in MNRAS on 2013 November 3

Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRα and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model

Purpose. Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment characterized by redetachment of the retina as a result of membrane formation and contraction. A variety of retinal cells, including retinal pigment epithelial (RPE) and Müller glia, and growth factors may be responsible. Platelet-derived growth factor receptor alpha (PDGFRα) is found in large quantities in PVR membranes, and is intrinsic to the development of PVR in rabbit models. This study explores the expression of PDGFR in cocultures of RPE and Müller cells over time to examine how these two cell types may collaborate in the development of PVR. We also examine how changes in PDGFRα expression alter Müller cell pathogenicity. Methods. Human MIO-M1 Müller progenitor (MPC) and ARPE19 cells were studied in a transmembrane coculture system. Immunocytochemistry and Western blot were used to look at PDGFRα, PDGFRβ, and GFAP expression. A transfected MPC line cell line expressing the PDGFRα (MIO-M1α) was generated, and tested in a rabbit model for its ability to induce PVR. Results:. The expression of PDGFRα and PDGFRβ was upregulated in MIO-M1 MPCs cocultured with ARPE19 cells; GFAP was slightly decreased. Increased expression of PDGFRα in the MIO-M1 cell line resulted in increased pathogenicity and enhanced ability to induce PVR in a rabbit model. Conclusions:. Müller and RPE cell interaction can lead to upregulation of PDGFRα and increased Müller cell pathogenicity. Müller cells may play a more active role than previously thought in the development of PVR membranes, particularly when stimulated by an RPE-cell-rich environment. Additional studies of human samples and in animal models are warranted

Kinematics and binaries in young stellar aggregates. II. NGC 6913 = M29

Between 1996 and 2003 we have obtained 226 high resolution spectra of 16 stars in the field of the young open cluster NGC 6913, to the aim of constraining its main properties and study its internal kinematics. Twelve of the program stars turned out to be members, one of them probably unbound. Nine are binaries (one eclipsing and another double lined) and for seven of them the observations allowed to derive the orbital elements. All but two of the nine discovered binaries are cluster members. In spite of the young age (a few Myr), the cluster already shows signs that could be interpreted as evidence of dynamical relaxation and mass segregation. However, they may be also the result of an unconventional formation scenario. The dynamical (virial) mass as estimated from the radial velocity dispersion is larger than the cluster luminous mass, which may be explained by a combination of the optically thick interstellar cloud that occults part of the cluster, the unbound state or undetected very wide binary orbit of some of the members that inflate the velocity dispersion and a high inclination for the axis of a possible cluster angular momentum. All discovered binaries are hard enough to survive average close encounters within the cluster and do not yet show sign of relaxation of the orbital elements to values typical of field binaries.Comment: Astron.Astrophys. submitted, 8 figures, 7 tables, 12 pages. Figures 1 and 6 degraded in quality with respect to originals to save file dimension

Optical Bandgap Formation in AlInGaN Alloys

We report on the spectral dynamics of the reflectivity, site-selectively excited photoluminescence,photoluminescence excitation, and time-resolved luminescence in quaternary AlInGaN epitaxial layers grown on GaN templates. The incorporation of a few percents of In into AlGaN causes significant smoothening of the band-bottom potential profile in AlInGaN layers owing to improved crystal quality. An abrupt optical bandgap indicates that a nearly lattice-matched AlInGaN/GaN heterostructure with large energy band offsets can be grown for high-efficiency light-emitting devices

Optical bandgap formation in AlInGaN alloys

We report on the spectral dynamics of the reflectivity, site-selectively excited photoluminescence,photoluminescence excitation, and time-resolved luminescence in quaternary AlInGaN epitaxial layers grown on GaN templates. The incorporation of a few percents of In into AlGaN causes significant smoothening of the band-bottom potential profile in AlInGaN layers owing to improved crystal quality. An abrupt optical bandgap indicates that a nearly lattice-matched AlInGaN/GaN heterostructure with large energy band offsets can be grown for high-efficiency light-emitting devices

Profilin-1 Is Expressed in Human Atherosclerotic Plaques and Induces Atherogenic Effects on Vascular Smooth Muscle Cells

.Here we monitored profilin-1 expression in human atherosclerotic plaques by immunofluorescent staining. The effects of recombinant profilin-1 on atherogenic signaling pathways and cellular responses such as DNA synthesis (BrdU-incorporation) and chemotaxis (modified Boyden-chamber) were evaluated in cultured rat aortic and human coronary vascular smooth muscle cells (VSMCs). Furthermore, the correlation between profilin-1 serum levels and the degree of atherosclerosis was assessed in humans.<0.001 vs. no atherosclerosis or control group).Profilin-1 expression is significantly enhanced in human atherosclerotic plaques compared to the normal vessel wall, and the serum levels of profilin-1 correlate with the degree of atherosclerosis in humans. The atherogenic effects exerted by profilin-1 on VSMCs suggest an auto-/paracrine role within the plaque. These data indicate that profilin-1 might critically contribute to atherogenesis and may represent a novel therapeutic target

ccd photometry of the m 67 cluster in the vilnius photometric system

The Vilnius photometric system, consisting of seven passbands at 345, 374, 405, 466, 516, 544 and 656 nm makes it possible to determine spectral classes (or temperatures), absolute magnitudes (or surface gravities), metallicities and peculiarity types for stars of all spectral types in the presence of interstellar reddening (Straizys 1977, 1992a, b). This makes the system very useful for the determination of the physical parameters of stars which are too faint to be studied by spectroscopic methods. The system is especially effective when used with CCD detectors which combine a wide field, high sensitivity and high photometric accuracy

The Need for Research on PTSD in Children and Adolescents: A commentary on Elliot et al., 2020

The recent release of the 11th version of The International Classification of Diseases (ICD?11: WHO, 2018) marked a significant departure from the previous similarities between it and the Diagnostic and Statistical Manual of Mental Disorders (DSM?5; APA, 2013) in terms of their conceptualization of posttraumatic stress disorder (PTSD). The ICD?11 proposed a reduced symptom set for PTSD and a sibling disorder called Complex PTSD. There have been numerous studies that have provided support for the integrity of, and distinction between, PTSD and CPTSD diagnoses in adult samples. Elliot and colleagues (2020) have added to the research literature by providing a valuable examination of the differences between ICD and DSM PTSD/CPTSD in a sample of youth aged 8 to 17 years. This commentary reviews this study and reflects on the need for greater understanding of developmental changes in the presentation of PTSD and Complex PTSD