Why are we not flooded by involuntary thoughts about the past and future? Testing the cognitive inhibition dependency hypothesis

© The Author(s) 2018In everyday life, involuntary thoughts about future plans and events occur as often as involuntary thoughts about the past. However, compared to involuntary autobiographical memories (IAMs), such episodic involuntary future thoughts (IFTs) have become a focus of study only recently. The aim of the present investigation was to examine why we are not constantly flooded by IFTs and IAMs given that they are often triggered by incidental cues while performing undemanding activities. One possibility is that activated thoughts are suppressed by the inhibitory control mechanism, and therefore depleting inhibitory control should enhance the frequency of both IFTs and IAMs. We report an experiment with a between-subjects design, in which participants in the depleted inhibition condition performed a 60-min high-conflict Stroop task before completing a laboratory vigilance task measuring the frequency of IFTs and IAMs. Participants in the intact inhibition condition performed a version of the Stroop task that did not deplete inhibitory control. To control for physical and mental fatigue resulting from performing the 60-min Stroop tasks in experimental conditions, participants in the control condition completed only the vigilance task. Contrary to predictions, the number of IFTs and IAMs reported during the vigilance task, using the probe-caught method, did not differ across conditions. However, manipulation checks showed that participants’ inhibitory resources were reduced in the depleted inhibition condition, and participants were more tired in the experimental than in the control conditions. These initial findings suggest that neither inhibitory control nor physical and mental fatigue affect the frequency of IFTs and IAMs.Peer reviewedFinal Published versio

The Weakening Outburst of the Young Eruptive Star V582 Aur

V582 Aur is a pre-main sequence FU Orionis type eruptive star, which entered a brightness minimum in 2016 March due to changes in the line-of-sight extinction. Here, we present and analyze new optical $B$, $V$, $R_C$ and $I_C$ band multiepoch observations and new near-infrared $J$, $H$ and $K_S$ band photometric measurements from 2018 January$-$2019 February, as well as publicly available mid-infrared WISE data. We found that the source shows a significant optical$-$near-infrared variability, and the current brightness minimum has not completely finished yet. If the present dimming originates from the same orbiting dust clump that caused a similar brightness variation in 2012, than our results suggest a viscous spreading of the dust particles along the orbit. Another scenario is that the current minimum is caused by a dust structure, that is entering and leaving the inner part of the system. The WISE measurements could be consistent with this scenario. Our long-term data, as well as an accretion disk modeling hint at a general fading of V582 Aur, suggesting that the source will reach the quiescent level in $\sim$80 years.Comment: 8 pages, 4 figures, accepted for publication in Ap

A Multi-Epoch, Multiwavelength Study of the Classical FUor V1515 Cyg Approaching Quiescence

Historically, FU Orionis-type stars are low-mass, pre-main-sequence stars. The members of this class experience powerful accretion outbursts and remain in an enhanced accretion state for decades or centuries. V1515 Cyg, a classical FUor, started brightening in the 1940s and reached its peak brightness in the late 1970s. Following a sudden decrease in brightness, it stayed in a minimum state for a few months, then started brightening for several years. We present the results of our ground-based photometric monitoring complemented with optical/near-infrared spectroscopic monitoring. Our light curves show a long-term fading with strong variability on weekly and monthly timescales. The optical spectra show P Cygni profiles and broad blueshifted absorption lines, common properties of FUors. However, V1515 Cyg lacks the P Cygni profile in the Ca II 8498 Å line, a part of the Ca infrared triplet, formed by an outflowing wind, suggesting that the absorbing gas in the wind is optically thin. The newly obtained near-infrared spectrum shows the strengthening of the CO bandhead and the FeH molecular band, indicating that the disk has become cooler since the last spectroscopic observation in 2015. The current luminosity of the accretion disk dropped from the peak value of 138 L ⊙ to about 45 L ⊙, suggesting that the long-term fading is also partly caused by the dropping of the accretion rate

Spermatozoal sensitive biomarkers to defective protaminosis and fragmented DNA

Human sperm DNA damage may have adverse effects on reproductive outcome. Infertile men possess substantially more spermatozoa with damaged DNA compared to fertile donors. Although the extent of this abnormality is closely related to sperm function, the underlying etiology of ensuing male infertility is still largely controversial. Both intra-testicular and post-testicular events have been postulated and different mechanisms have been proposed to explain the presence of damaged DNA in human spermatozoa. Three among them, i.e. abnormal chromatin packaging, oxidative stress and apoptosis, are the most studied and discussed in the present review. Furthermore, results from numerous investigations are presented, including our own findings on these pathological conditions, as well as the techniques applied for their evaluation. The crucial points of each methodology on the successful detection of DNA damage and their validity on the appraisal of infertile patients are also discussed. Along with the conventional parameters examined in the standard semen analysis, evaluation of damaged sperm DNA seems to complement the investigation of factors affecting male fertility and may prove an efficient diagnostic tool in the prediction of pregnancy outcome

Paternal effects on early embryogenesis

Historically, less attention has been paid to paternal effects on early embryogenesis than maternal effects. However, it is now apparent that certain male factor infertility phenotypes are associated with increased DNA fragmentation and/or chromosome aneuploidies that may compromise early embryonic development. In addition, there is a growing body of evidence that the fertilizing sperm has more function than just carrying an intact, haploid genome. The paternally inherited centrosome is essential for normal fertilization, and the success of higher order chromatin packaging may impact embryogenesis. Epigenetic modifications of sperm chromatin may contribute to the reprogramming of the genome, and sperm delivered mRNA has also been hythesized to be necessary for embryogenesis. There is less information about the epigenetic factors affecting embryogenesis than genetic factors, but the epigenetics of gamete and early embryogenesis is a rapidly advancing field

The Type II-P Supernova 2017eaw: From Explosion to the Nebular Phase

The nearby SN 2017eaw is a Type II-P ("plateau") supernova (SN) showing early-time, moderate CSM interaction. We present a comprehensive study of this SN, including the analysis of high-quality optical photometry and spectroscopy covering the very early epochs up to the nebular phase, as well as near-ultraviolet and near-infrared spectra and early-time X-ray and radio data. The combined data of SNe 2017eaw and 2004et allow us to get an improved distance to the host galaxy, NGC. 6946, of D similar to 6.85 +/- 0.63 Mpc; this fits into recent independent results on the distance of the host and disfavors the previously derived (30% shorter) distances based on SN 2004et. From modeling the nebular spectra and the quasi-bolometric light curve, we estimate the progenitor mass and some basic physical parameters for the explosion and ejecta. Our results agree well with previous reports on a red supergiant progenitor star with a mass of similar to 15-16 M-circle dot. Our estimation of the pre-explosion mass-loss rate ((M)over dot similar to 3 x 10(-7)-1 x 10(-6)M(circle dot) yr(-1)) agrees well with previous results based on the opacity of the dust shell enshrouding the progenitor, but it is orders of magnitude lower than previous estimates based on general light-curve modeling of Type II-P SNe. Combining late-time optical and mid-infrared data, a clear excess at 4.5 mu m can be seen, supporting the previous statements on the (moderate) dust formation in the vicinity of SN 2017eaw

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes

Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm contain a number of molecules and pathways for the repair of base excision, base mismatches and DNA strand breaks. The presence of Poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme, and its homologues has recently been shown in male germ cells, specifically during stage VII of spermatogenesis. High PARP expression has been reported in mature spermatozoa and in proven fertile men. Whenever there are strand breaks in sperm DNA due to oxidative stress, chromatin remodeling or cell death, PARP is activated. However, the cleavage of PARP by caspase-3 inactivates it and inhibits PARP's DNA-repairing abilities. Therefore, cleaved PARP (cPARP) may be considered a marker of apoptosis. The presence of higher levels of cPARP in sperm of infertile men adds a new proof for the correlation between apoptosis and male infertility. This review describes the possible biological significance of PARP in mammalian cells with the focus on male reproduction. The review elaborates on the role played by PARP during spermatogenesis, sperm maturation in ejaculated spermatozoa and the potential role of PARP as new marker of sperm damage. PARP could provide new strategies to preserve fertility in cancer patients subjected to genotoxic stresses and may be a key to better male reproductive health

Raman micro-spectroscopy can be used to investigate the developmental stage of the mouse oocyte

In recent years, the uptake of assisted reproductive techniques such as in vitro fertilisation has risen exponentially. However, there is much that is still not fully understood about the biochemical modifications that take place during the development and maturation of the oocyte. As such, it is essential to further the understanding of how oocyte manipulation during these procedures ultimately affects its developmental potential; yet, there are few methods currently available which are capable of providing a quantitative measure of oocyte quality. Raman spectroscopy enables investigation of the global biochemical profile of intact cells without the need for labelling. Here, Raman spectra were acquired from the ooplasm of mouse oocytes at various stages of development, from late pre-antral follicles, collected after in vitro maturation within their ovarian follicles and from unstimulated and stimulated ovulatory cycles. Using a combination of univariate and multivariate statistical methods, it was found that ooplasm lipid content could be used to discriminate between different stages of oocyte development. Furthermore, the spectral profiles of mature oocytes revealed that oocytes which have developed in vitro are protein-deficient when compared to in vivo grown oocytes. Finally, the ratio of two Raman peak intensities, namely 1605:1447 cm21, used as a proxy for the protein-to-lipid ratio of the ooplasm, was shown to be indicative of the oocyte’s quality. Together, results indicate that Raman spectroscopy may present an alternative analytical tool fo