6,201 research outputs found
Control of Brain Development, Function and Behavior by the Microbiome
Animals share an intimate and life-long partnership with a myriad of resident microbial species, collectively
referred to as the microbiota. Symbiotic microbes have been shown to regulate nutrition and metabolism and
are critical for the development and function of the immune system. More recently, studies have suggested
that gut bacteria can impact neurological outcomes—altering behavior and potentially affecting the onset
and/or severity of nervous system disorders. In this review, we highlight emerging evidence that the microbiome
extends its influence to the brain via various pathways connecting the gut to the central nervous system.
While understanding and appreciation of a gut microbial impact on neurological function is nascent,
unraveling gut-microbiome-brain connections holds the promise of transforming the neurosciences and
revealing potentially novel etiologies for psychiatric and neurodegenerative disorders
I can see CRISPR now, even when phage are gone: a view on alternative CRISPR-Cas functions from the prokaryotic envelope
Purpose of review: CRISPR-Cas systems are prokaryotic immune systems against invading nucleic acids that adapt as new environmental threats arise. There are emerging examples of CRISPR-Cas functions in bacterial physiology beyond their role in adaptive immunity. This highlights the poorly understood, but potentially common, moonlighting functions of these abundant systems. We propose that these noncanonical CRISPR-Cas activities have evolved to respond to stresses at the cell envelope.
Recent findings: Here, we discuss recent literature describing the impact of the extracellular environment on the regulation of CRISPR-Cas systems, and the influence of CRISPR-Cas activity on bacterial physiology. These described noncanonical CRISPR-Cas functions allow the bacterial cell to respond to the extracellular environment, primarily through changes in envelope physiology.
Summary: This review discusses the expanding noncanonical functions of CRISPR-Cas systems, including their roles in virulence, focusing mainly on their relationship to the cell envelope. We first examine the effects of the extracellular environment on regulation of CRISPR-Cas components, and then discuss the impact of CRISPR-Cas systems on bacterial physiology, concentrating on their roles in influencing interactions with the environment including host organisms
Shrimp hatchery
Successful spawning of Penaeus japonicus
under controlled conditions and their subsequent
rearing upto the juvenile stage by Hudinaga
(1942) and his team paved way for the large scale
hatchery production of shrimp seed for aquaculture
The Central Nervous System and the Gut Microbiome
Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals. While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggest communication between the gut and the brain in anxiety, depression, cognition, and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut. These cues largely originate from the microbiome, the consortium of symbiotic bacteria that reside within all animals. Research over the past few years reveals that the gut microbiome plays a role in basic neurogenerative processes such as the formation of the blood-brain barrier, myelination, neurogenesis, and microglia maturation and also modulates many aspects of animal behavior. Herein, we discuss the biological intersection of neurodevelopment and the microbiome and explore the hypothesis that gut bacteria are integral contributors to development and function of the nervous system and to the balance between mental health and disease
UV and X-ray Spectral Lines of FeXXIII Ion for Plasma Diagnostics
We have calculated X-ray and UV spectra of Be-like Fe (FeXXIII) ion in
collisional-radiative model including all fine-structure transitions among the
2s^2, 2s2p, 2p^2, 2snl, and 2pnl levels where n=3 and 4, adopting data for the
collision strengths by Zhang & Sampson (1992) and by Sampson, Goett, & Clark
(1984). Some line intensity ratios can be used for the temperature diagnostics.
We show 5 ratios in UV region and 9 ratios in X-ray region as a function of
electron temperature and density at 0.3keV < T_e < 10keV and . The effect of cascade in these line ratios and in the level
population densities are discussed.Comment: LaTeX, 18 pages, 10 Postscript figures. To appear in Physica Script
The Central Nervous System and the Gut Microbiome
Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals. While historically studied by researching the brain, inputs from the periphery impact many neurological conditions. Indeed, emerging data suggest communication between the gut and the brain in anxiety, depression, cognition, and autism spectrum disorder (ASD). The development of a healthy, functional brain depends on key pre- and post-natal events that integrate environmental cues, such as molecular signals from the gut. These cues largely originate from the microbiome, the consortium of symbiotic bacteria that reside within all animals. Research over the past few years reveals that the gut microbiome plays a role in basic neurogenerative processes such as the formation of the blood-brain barrier, myelination, neurogenesis, and microglia maturation and also modulates many aspects of animal behavior. Herein, we discuss the biological intersection of neurodevelopment and the microbiome and explore the hypothesis that gut bacteria are integral contributors to development and function of the nervous system and to the balance between mental health and disease
The ROTSE-III Robotic Telescope System
The observation of a prompt optical flash from GRB990123 convincingly
demonstrated the value of autonomous robotic telescope systems. Pursuing a
program of rapid follow-up observations of gamma-ray bursts, the Robotic
Optical Transient Search Experiment (ROTSE) has developed a next-generation
instrument, ROTSE-III, that will continue the search for fast optical
transients. The entire system was designed as an economical robotic facility to
be installed at remote sites throughout the world. There are seven major system
components: optics, optical tube assembly, CCD camera, telescope mount,
enclosure, environmental sensing & protection and data acquisition. Each is
described in turn in the hope that the techniques developed here will be useful
in similar contexts elsewhere.Comment: 19 pages, including 4 figures. To be published in PASP in January,
2003. PASP Number IP02-11
Precautionary labelling of foods for allergen content: are we ready for a global framework?
© 2014 Allen et al.; licensee BioMed Central Ltd.Food allergy appears to be on the rise with the current mainstay of treatment centred on allergen avoidance. Mandatory allergen labelling has improved the safety of food for allergic consumers. However an additional form of voluntary labelling (termed precautionary allergen labelling) has evolved on a wide range of packaged goods, in a bid by manufacturers to minimise risk to customers, and the negative impact on business that might result from exposure to trace amounts of food allergen present during cross-contamination during production. This has resulted in near ubiquitous utilisation of a multitude of different precautionary allergen labels with subsequent confusion amongst many consumers as to their significance. The global nature of food production and manufacturing makes harmonisation of allergen labelling regulations across the world a matter of increasing importance. Addressing inconsistencies across countries with regards to labelling legislation, as well as improvement or even banning of precautionary allergy labelling are both likely to be significant steps forward in improved food safety for allergic families. This article outlines the current status of allergen labelling legislation around the world and reviews the value of current existing precautionary allergen labelling for the allergic consumer. We strongly urge for an international framework to be considered to help roadmap a solution to the weaknesses of the current systems, and discuss the role of legislation in facilitating this
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice
Parkinson’s disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonomic fibers. We tested this by inoculating the duodenal wall of mice with α-Syn preformed fibrils. Following inoculation, we observed gastrointestinal deficits and physiological changes to the enteric nervous system. Using the AAV-PHP.S capsid to target the lysosomal enzyme glucocerebrosidase for peripheral gene transfer, we found that α-Syn pathology is reduced due to the increased expression of this protein. Lastly, inoculation of α-Syn fibrils in aged mice, but not younger mice, resulted in progression of α-Syn histopathology to the midbrain and subsequent motor defects. Our results characterize peripheral synucleinopathy in prodromal Parkinson’s disease and explore cellular mechanisms for the gut-to-brain progression of α-Syn pathology
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