10,179 research outputs found
Predictions of cardiovascular responses during STS reentry using mathematical models
The physiological adaptation to weightless exposure includes cardiovascular deconditioning arising in part from a loss of total circulating blood volume and resulting in a reduction of orthostatic tolerance. The crew of the Shuttle orbiter are less tolerant to acceleration forces in the head-to-foot direction during the reentry phase of the flight at a time they must function at a high level of performance. The factors that contribute to orthostatic intolerance during and following reentry and to predict the likelihood of impaired crew performance are evaluated. A computer simulation approach employing a mathematical model of the cardiovascular system is employed. It is shown that depending on the severity of blood volume loss, the reentry acceleration stress may be detrimental to physiologic function and may place the physiologic status of the crew near the borderline of some type of impairment. They are in agreement with conclusions from early ground-based experiments and from observations of early Shuttle flights
An integrative approach to space-flight physiology using systems analysis and mathematical simulation
An approach was developed to aid in the integration of many of the biomedical findings of space flight, using systems analysis. The mathematical tools used in accomplishing this task include an automated data base, a biostatistical and data analysis system, and a wide variety of mathematical simulation models of physiological systems. A keystone of this effort was the evaluation of physiological hypotheses using the simulation models and the prediction of the consequences of these hypotheses on many physiological quantities, some of which were not amenable to direct measurement. This approach led to improvements in the model, refinements of the hypotheses, a tentative integrated hypothesis for adaptation to weightlessness, and specific recommendations for new flight experiments
Intrinsic and Rashba Spin-orbit Interactions in Graphene Sheets
Starting from a microscopic tight-binding model and using second order
perturbation theory, we derive explicit expressions for the intrinsic and
Rashba spin-orbit interaction induced gaps in the Dirac-like low-energy band
structure of an isolated graphene sheet. The Rashba interaction parameter is
first order in the atomic carbon spin-orbit coupling strength and first
order in the external electric field perpendicular to the graphene plane,
whereas the intrinsic spin-orbit interaction which survives at E=0 is second
order in . The spin-orbit terms in the low-energy effective Hamiltonian
have the form proposed recently by Kane and Mele. \textit{Ab initio} electronic
structure calculations were performed as a partial check on the validity of the
tight-binding model.Comment: 5 pages, 2 figures; typos corrected, references update
Dynamics of polydisperse irreversible adsorption: a pharmacological example
Many drug delivery systems suffer from undesirable interactions with the host immune system. It has been experimentally established that covalent attachment (irreversible adsorption) of suitable macromolecules to the surface of the drug carrier can reduce such undesirable interactions. A fundamental understanding of the adsorption process is still lacking. In this paper, the classical random irreversible adsorption model is generalized to capture certain essential processes involved in pharmacological applications, allowing for macromolecules of different sizes, partial overlapping of the tails of macromolecules, and the influence of reactions with the solvent on the adsorption process. Working in one dimension, an integro-differential evolution equation for the adsorption process is derived, and the asymptotic behavior of the surface area covered and the number of molecules attached to the surface are studied. Finally, equation-free dynamic renormalization tools are applied to study the asymptotically self-similar behavior of the adsorption statistics
Exciton gas transport through nano-constrictions
An indirect exciton is a bound state of an electron and a hole in spatially
separated layers. Two-dimensional indirect excitons can be created optically in
heterostructures containing double quantum wells or atomically thin
semiconductors. We study theoretically transmission of such bosonic
quasiparticles through nano-constrictions. We show that quantum transport
phenomena, e.g., conductance quantization, single-slit diffraction, two-slit
interference, and the Talbot effect, are experimentally realizable in systems
of indirect excitons. We discuss similarities and differences between these
phenomena and their counterparts in electronic devices.Comment: (v2) Updated title, text, and references; 12 pages, 9 figure
Seleksi Galur Kedelai (Glycine Max (L.) Merril) Generasi F4 Pada Tanah Salin
Strain Selection of Soybean (Glycine max (L)Merril) of F4 Generation on Saline Soil. This researchaims to select the soybeans that can grow well and good production on saline soil of F4 generation.This research was conducted at Tanjung Rejo village,subdistrict of Percut Sei Tuan, Regenecy ofDeli Serdang,the elevation is 1.5m on above sea level,since November 2012 up to January 2013.The analysis used in this research is fingerprint analysis of cross that consist of 1 variety, themethod applied is a F4 generation pedigree selection,the population is sample, number of live plantis 43 of 690. The selected plant is based on the grain production per plant for 30 plants.Based on theresults of research that based on the highest weight of seed per plant is 1.4g on the plant number514.1.8.6 and the lowest production is 0.1g on the plant number 88.5.10.2, 1298.5.3.1, 1298.5.3.30,1298.5.3.40, 1298.5.7.16 and 1298.5.7.25. The components of production that has a direct influenceto the grain production per plant are the number of branch,age of flowering,number of pod andnumber of pods contain. Component of production that giving the highest direct influence is thenumber of pod contain for 8.809
Green Fluorescent Protein in the sea urchin: new experimental approaches to transcriptional regulatory analysis in embryos and larvae
The use of Green Fluorescent Protein (GFP) as a reporter
for expression transgenes opens the way to several new
experimental strategies for the study of gene regulation in
sea urchin development. A GFP coding sequence was associated
with three different previously studied cis-regulatory
systems, viz those of the SM50 gene, expressed in skeletogenic mesenchyme, the CyIIa gene, expressed in archenteron, skeletogenic and secondary mesenchyme, and the
Endo16 gene, expressed in vegetal plate, archenteron and
midgut. We demonstrate that the sensitivity with which
expression can be detected is equal to or greater than that
of whole-mount in situ hybridization applied to detection
of CAT mRNA synthesized under the control of the same
cis-regulatory systems. However, in addition to the
important feature that it can be visualized nondestructively
in living embryos, GFP has other advantages. First, it freely diffuses even within fine cytoplasmic cables, and thus reveals connections between cells, which in sea urchin
embryos is particularly useful for observations on regulatory systems that operate in the syncytial skeletogenic mesenchyme. Second, GFP expression can be dramatically visualized in postembryonic larval tissues. This brings postembryonic larval developmental processes for the first time within the easy range of gene transfer analyses. Third, GFP permits identification and segregation of embryos in which the clonal incorporation of injected DNA has occurred in any particular desired region of the embryo. Thus, we show explicitly that, as expected, GFP transgenes are incorporated in the same nuclei together with other transgenes with which they are co-injected
Kinetic pinning and biological antifreezes
Biological antifreezes protect cold-water organisms from freezing. An example
are the antifreeze proteins (AFPs) that attach to the surface of ice crystals
and arrest growth. The mechanism for growth arrest has not been heretofore
understood in a quantitative way. We present a complete theory based on a
kinetic model. We use the `stones on a pillow' picture. Our theory of the
suppression of the freezing point as a function of the concentration of the AFP
is quantitatively accurate. It gives a correct description of the dependence of
the freezing point suppression on the geometry of the protein, and might lead
to advances in design of synthetic AFPs.Comment: 4 pages, 4 figure
Spotlight commentary: A role for real-world evidence to inform the clinical care of patients with diabetes mellitus
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