1,520 research outputs found
Test of 0.14-Scale Models of the Control Surfaces of Army Project MX-511 in Attitudes Simulating Spins
Wind-tunnel investigation of the effect of power and flaps on the static lateral stability and control characteristics of a single-engine high-wing airplane model
Clinical and molecular correlates in fragile X premutation females.
The prevalence of the fragile X premutation (55-200 CGG repeats) among the general population is relatively high, but there remains a lack of clear understanding of the links between molecular biomarkers and clinical outcomes. In this study we investigated the correlations between molecular measures (CGG repeat size, FMR1 mRNA, FMRP expression levels, and methylation status at the promoter region and in FREE2 site) and clinical phenotypes (anxiety, obsessive compulsive symptoms, depression and executive function deficits) in 36 adult premutation female carriers and compared to 24 normal control subjects. Premutation carriers reported higher levels of obsessive compulsive symptoms, depression, and anxiety, but demonstrated no significant deficits in global cognitive functions or executive function compared to the control group. Increased age in carriers was significantly associated with increased anxiety levels. As expected, FMR1 mRNA expression was significantly correlated with CGG repeat number. However, no significant correlations were observed between molecular (including epigenetic) measures and clinical phenotypes in this sample. Our study, albeit limited by the sample size, establishes the complexity of the mechanisms that link the FMR1 locus to the clinical phenotypes commonly observed in female carriers suggesting that other factors, including environment or additional genetic changes, may have an impact on the clinical phenotypes. However, it continues to emphasize the need for assessment and treatment of psychiatric problems in female premutation carriers
Effect of aspect ratio and sweepback on the low-speed lateral control characteristics of untapered low-aspect-ratio wings equipped with retractable ailerons
Investigation of Extensible Wing-tip Ailerons on an Untapered Semispan Wing at 0 Degree and 45 Degrees Sweepback
Wing-tunnel Investigation at High Subsonic Speeds of the Lateral-control Characteristics of an Aileron and a Stepped Spoiler on a Wing with Leading Edge Swept Back 51.3 Degrees
Wind-tunnel Investigation at Low Speed of the Lateral Control Characteristics of an Unswept Untapered Semi-span Wing of Aspect Ratio 3.13 Equipped with Various 25-percent-chord Plain Ailerons
Wind-tunnel investigation at low speed of lateral control characteristics of an untapered 45 degrees sweptback semispan wing of aspect ratio 1.59 equipped with various 25-percent-chord plain ailerons
Aerodynamic characteristics at transonic speeds of a tapered 45 degree sweptback wing of aspect ratio 3 having a full-span flap type of control with overhang balance : transonic-bump method
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy. METHODS: Method and outcome classification of the study complied with WHO guidelines. Children 6-59 months with uncomplicated malaria were followed-up for 28 days. PCR genotyping was used to distinguish recrudescence from reinfection. Reinfections were reclassified as cured. RESULTS: Of 172 children who were referred to the study clinic, 126 satisfied inclusion criteria and were enrolled. No early treatment failures were reported. The day 14, efficacy was 98.2% (95% CI: 93.8-99.8). Of 65 recurrent parasitaemias analysed by PCR, 17 were recrudescences. The PCR-adjusted day 28 efficacy was 84.5% (95% CI: 76.4-90.7). All true failures occurred in the last 8 days of follow-up. Of 110 children who completed the 28-day follow-up, 54 (49.1%) experienced a novel infection. CONCLUSION: The efficacy of this combination was disappointing. The high reinfection rate suggested little prophylactic effect. In Kailahun a more efficacious combination might be necessary in the future. The efficacy of AS + AQ needs to be monitored in Kailahun and in the other regions of Sierra Leone
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