4,867 research outputs found

    EFICÁCIA DE COLOIDES VS CRISTALOIDES NA REPOSIÇÃO VOLÉMICA A NÍVEL HEPÁTICO EM PACIENTES HEMORRÁGICOS

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    Apesar dos avanços na sua abordagem terapêutica, a hemorragia severa continua a ser a principal causa de morbilidade e mortalidade em animais vítimas de trauma ou sujeitos a intervenção cirúrgica. A causa das lesões decorrentes, ou da morte consequente, deve-se ao deficit de volume de fluidos intravasculares e subsequente desenvolvimento do estado hipovolémico.O controlo da hipovolémia passa pela resolução da hemorragia e pela correção do deficit de volume intravascular causado e envolve, obrigatoriamente, o recurso à administração de fluidos intravenosos. A escolha do tipo de fluido mais adequado para a terapia intravenosa (IV), em cada ocorrência, é uma tarefa que exige reflexão e ponderação. O objetivo deste trabalho consistiu na avaliação do tipo de fluido mais adequado e eficiente para efetuar a reposição volémica em pacientes hemorrágicos, em particular no respeitante a qual deles acarreta menor comprometimento da função hepática. As lesões histopatológicas avaliadas nos diferentes grupos deste estudo não revelaram diferenças estatisticamente significativas entre os 3 grupos, o que validou a possibilidade de se usar qualquer um dos fluidos testados. Contudo, foi notória uma maior intensidade da gravidade das lesões no grupo 2. Assim, foi possível concluir que o uso do hidroxietilamido 130/0,4, em detrimento do lactato de Ringer em situações de hipovolémia, contribui para a preservação da integridade histológica e fisiológica hepática.COMPETE - FCOMP-01-0124-FEDER-009525; FCT/CI&DETS (PEst- OE/CED/UI4016/2011

    Immediate implant placement in fresh alveolar sockets with a minimal split-thickness envelope flap: A randomised controlled clinical trial

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    OBJECTIVES: Comparing PES/WES scores, modified success rate, survival, success, buccal bone thickness and patient-reported outcomes of immediate dental implants placed in fresh alveolar sockets using a flap or a minimal split-thickness envelope flap (MSTEF). MATERIALS AND METHODS: Implants following random assignment into a flap or MSTEF group were placed immediately in anterior and premolar areas. Guided bone regeneration and autogenous connective tissue graft were used in all cases. A temporary prosthesis was provided followed by the final prosthesis at 16-18 weeks. Success and survival rates together with radiographic buccal bone thickness and patient satisfaction were evaluated at 12 months post-loading. The aesthetic outcome was evaluated through the Pink (PES) and White (WES) Aesthetic Score by 8 blind clinicians of different training background and incorporated in modified success criteria. RESULTS: 28 implants were placed on 28 patients. No statistically significant differences were noted in PES (10.54 control vs. 10.80 test), WES scores (6.97 control vs. 6.95 test) or success criteria including aesthetic parameters (modified success criteria) for the different specialty groups (Range 69%-92%). In addition, no statistically significant differences were noted in survival (100%), success (100%), buccal wall thickness between control (0.72 +/-0.22) and test group (0.92+/-0.31) and patients' reported outcomes. CONCLUSIONS: Immediate dental implant treatment with flap/ MSTEF provided similar mean PES/WES scores, modified success rate, survival, mean buccal bone levels and patients' satisfaction. However, aesthetic failures were common in both groups

    Immediate implant placement in fresh alveolar sockets with a minimal split-thickness envelope flap. A randomised controlled clinical trial.

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    OBJECTIVES: Comparing PES/WES scores, modified success rate, survival, success, buccal bone thickness and patient-reported outcomes of immediate dental implants placed in fresh alveolar sockets using a flap or a minimal split-thickness envelope flap (MSTEF). MATERIALS AND METHODS: Implants following random assignment into a flap or MSTEF group were placed immediately in anterior and premolar areas. Guided bone regeneration and autogenous connective tissue graft were used in all cases. A temporary prosthesis was provided followed by the final prosthesis at 16-18 weeks. Success and survival rates together with radiographic buccal bone thickness and patient satisfaction were evaluated at 12 months post-loading. The aesthetic outcome was evaluated through the Pink (PES) and White (WES) Aesthetic Score by 8 blind clinicians of different training background and incorporated in modified success criteria. RESULTS: 28 implants were placed on 28 patients. No statistically significant differences were noted in PES (10.54 control vs. 10.80 test), WES scores (6.97 control vs. 6.95 test) or success criteria including aesthetic parameters (modified success criteria) for the different specialty groups (Range 69%-92%). In addition, no statistically significant differences were noted in survival (100%), success (100%), buccal wall thickness between control (0.72 +/-0.22) and test group (0.92+/-0.31) and patients' reported outcomes. CONCLUSIONS: Immediate dental implant treatment with flap/ MSTEF provided similar mean PES/WES scores, modified success rate, survival, mean buccal bone levels and patients' satisfaction. However, aesthetic failures were common in both groups

    Preliminary Measurements of Be-10/Be-7 Ratio in Rainwater for Atmospheric Transport Analysis

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    The meteoric cosmogenic beryllium has been used as an essential geophysical tracer in the analysis of atmospheric flows and erosion soils since 1960. The first measurements Be-7 and Be-10 concentrations in rainwater from Mexico, have been carried out by using gamma decay spectroscopy and AMS techniques, respectively for each isotope. With this it was possible to report a preliminar value for the Be-10/Be-7 isotopic ratio in such environmental samples. The present work described preliminary results related to rainwater collected at mountain and metropolitan areas. Results are compared with predictions and previous measurements for both radioisotopes, observing a very sensible behavior particularly for the case of Be-7 activities

    Evaluation of total phenolics, anthocyanins and antioxidant capacity in purple tomatillo (Physalis ixocarpa) genotypes

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    Purple tomatillo genotypes were evaluated for their total anthocyanin, phenolic and antioxidant capacity. The result showed that ICTS-UDG-9-224 and ICTS-UDG-9-32 had the highest amount of total phenolic compounds 10.08 and 9.6 mg GAE/g fresh weight in genotypes, respectively, followed by ICTS-UDG-1-1 and ICTS-UDG-2-2 (5.5 and 5.3 mg GAE/g fresh weight), respectively. The highest content of anthocyanins was found in the genotypes ICTS-UDG-9-32 (6.94 mg of pelargonidin 3-glucoside equivalents/g of fresh weight). In contrast, the genotypes ICTS-UDG-9-224 showed lowest values of antocyanins content. On the other hand, for total antioxidant capacity, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods showed that genotypes, ICTS-UDG-2-2 and ICTS-UDG-1-1 had the highest antioxidant capacity (approximately 80%) followed by genotypes ICTS-UDG-9-32 (55%) and ICTS-UDG-9-224 (28%), respectively. These results provide useful and important information for researchers in order to increase the antioxidant capacity and functional value of purple tomatillo for the food and nutraceutical industries.Key word: Antocyanins, purple tomatillos, bioactive compounds, antioxidant capacity

    Traversing the pyrochlore stability diagram; microwave-assisted synthesis and discovery of mixed B-site Ln2_2InSbO7_7 family

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    The lanthanide pyrochlore oxides Ln2_2B2_2O7_7 are one of the most intensely studied classes of materials within condensed matter physics, firmly centered as one of the pillars of frustrated magnetism. The extensive chemical diversity of the pyrochlores, coupled with their innate geometric frustration, enables realization of a wide array of exotic and complex magnetic ground states. Thus, the discovery of new pyrochlore compositions has been a persistent theme that continues to drive the field in exciting directions. The recent focus on the mixed B-site pyrochlores offers a unique route towards tuning both local coordination chemistry and sterics, while maintaining a nominally pristine magnetic sublattice. Here, we present a broad overview of the pyrochlore stability field, integrating recent synthetic efforts in mixed B-site systems with the historically established Ln2_2B2_2O7_7 families. In parallel, we present the discovery and synthesis of the entire Ln2_2InSbO7_7 family (Ln: La, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) located near the boundary of the pyrochlore stability field using a rapid, hybrid mechanicochemical/microwave-assisted synthesis technique. Magnetic characterization on the entire class of compounds draws striking parallels to the stannate analogs, suggesting that these compounds may host a breadth of exotic magnetic ground states

    Determinación de órganos diana para la multiplicación y persistencia del virus de la enfermedad de linfocistis (LCDV) en dorada (Sparus aurata, L.)

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    La enfermedad de linfocistis es la única patología de etiología viral descrita en dorada cultivada En la cuenca mediterr nea, la prevalencia es cercana al 100 , ocasionando graves p rdidas económicas debido a la imposibilidad de comercializar los peces afectados En el presente trabajo se ha abordado el estudio de la patog nesis del virus de la enfermedad de linfocistis (LCDV) en dorada, además se han establecido los órganos implicados en la multiplicación vírica Para ello, se ha diseñado un protocolo de hibridación in situ empleando sondas RNA marcadas con digoxigenina dirigidas contra el gen que codifica la proteína principal de la cápside (MCP) viral, y se ha evaluado en poblaciones de dorada. En paralelo, se ha procedido a la cuantificación del número de copias de genoma viral por PCR a tiempo real y cuantificación relativa de la transcripción del gen que codifica la MCP viral mediante qRT-PCR. Los resultados obtenidos indican que el LCDV establece una infección sistémica en alevines de dorada, pudiendo detectarse señal de hibridación tanto en órganos internos (hígado, bazo, riñón) como en músculo y aleta. También se han observado diversos daños histopatológicos en animales enfermos, mientras que en animales recuperados de la enfermedad estos daños parecen revertir, aunque en estos animales la infección persiste, si bien sólo a niveles detectables mediante PCR a tiempo real.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

    Detection of apoptotic events, using different methods, in renal tissues after acute haemorrhage.

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    Apoptosis plays an important role in cellular damage caused by acute renal hypoperfusion. The aim of this study was to detect apoptotic events in an animal model of acute haemorrhage, followed by volume replacement with different intravenous solution
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