343 research outputs found
Introducing a rainfall compound distribution model based on weather patterns sub-sampling
This paper presents a probabilistic model for daily rainfall, using sub-sampling based on meteorological circulation. We classified eight typical but contrasted synoptic situations (weather patterns) for France and surrounding areas, using a "bottom-up" approach, i.e. from the shape of the rain field to the synoptic situations described by geopotential fields. These weather patterns (WP) provide a discriminating variable that is consistent with French climatology, and allows seasonal rainfall records to be split into more homogeneous sub-samples, in term of meteorological genesis. <br><br> First results show how the combination of seasonal and WP sub-sampling strongly influences the identification of the asymptotic behaviour of rainfall probabilistic models. Furthermore, with this level of stratification, an asymptotic exponential behaviour of each sub-sample appears as a reasonable hypothesis. This first part is illustrated with two daily rainfall records from SE of France. <br><br> The distribution of the multi-exponential weather patterns (MEWP) is then defined as the composition, for a given season, of all WP sub-sample marginal distributions, weighted by the relative frequency of occurrence of each WP. This model is finally compared to Exponential and Generalized Pareto distributions, showing good features in terms of robustness and accuracy. These final statistical results are computed from a wide dataset of 478 rainfall chronicles spread on the southern half of France. All these data cover the 1953â2005 period
Synthesis, coordination study, and catalytic PausonâKhand reactions of QuinoxP*(CO)4âÎŒ-alkyne dicobalt complexes
The coordination of the P-stereogenic and sterically demanding bisphosphine QuinoxP* to ÎŒ-alkyne dicobalt hexacarbonyl complexes was studied experimentally and computationally. Whereas the coordination occurred exclusively in a chelating fashion, the diastereoselectivity was highly substrate dependent. However, it could be explained from the computed structure and energies of the different coordination modes. The fluxional behavior of these complexes was also studied computationally. Their performance as catalysts for the PausonâKhand reaction was explored, and outstanding reactivity was observed. Although the asymmetric induction was low to moderate, the stereochemical outcome could be mechanistically rationalized. This report provides promising results in terms of reactivity and mechanistic understanding for further developments of highly active chiral catalysts for intermolecular PausonâKhand reactions
Sensitivity of tensor analyzing power in the process to the longitudinal isoscalar form factor of the Roper resonance electroexcitation
The tensor analyzing power of the process , for forward
deuteron scattering in the momentum interval 3.7 to 9 GeV/c, is studied in the
framework of exchange in an algebraic collective model for the
electroexcitation of nucleon resonances. We point out a special sensitivity of
the tensor analyzing power to the isoscalar longitudinal form factor of the
Roper resonance excitation. The main argument is that the ,
and resonances have only isovector longitudinal
form factors. It is the longitudinal form factor of the Roper excitation, which
plays an important role in the dependence of the tensor analyzing power. We
discuss possible evidence of swelling of hadrons with increasing excitation
energy.Comment: 12 pages, 10 figure
Comparison of Relativistic Nucleon-Nucleon Interactions
We investigate the difference between those relativistic models based on
interpreting a realistic nucleon-nucleon interaction as a perturbation of the
square of a relativistic mass operator and those models that use the method of
Kamada and Gl\"ockle to construct an equivalent interaction to add to the
relativistic mass operator. Although both models reproduce the phase shifts and
binding energy of the corresponding non-relativistic model, they are not
scattering equivalent. The example of elastic electron-deuteron scattering in
the one-photon-exchange approximation is used to study the sensitivity of
three-body observables to these choices. Our conclusion is that the differences
in the predictions of the two models can be understood in terms of the
different ways in which the relativistic and non-relativistic -matrices are
related. We argue that the mass squared method is consistent with conventional
procedures used to fit the Lorentz-invariant cross section as a function of the
laboratory energy.Comment: Revtex 13 pages, 5 figures, corrected some typo
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model
Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell behavior within tumors, as well as spatial and temporal heterogeneity in response to immunotherapy. Here we describe an experimental approach for intravital imaging of adoptive T-cell morphology, mobility and trafficking in a skin-flap tumor model, following immune modulation with immune checkpoint inhibitors (ICIs) targeting PD-L1 and CTLA-4. A syngeneic model of ovalbumin and mCherry-expressing amelanotic mouse melanoma was used in conjunction with adoptively transferred OT-1+ cytotoxic T-cells expressing GFP to image antigen-specific live T-cell behavior within the tumor microenvironment. Dynamic image analysis of T-cell motility showed distinct CD8+ T-cell migration patterns and morpho-dynamics within different tumor compartments in response to ICIs: this approach was used to cluster T-cell behavior into four groups based on velocity and meandering index. The results showed that most T-cells within the tumor periphery demonstrated LĂ©vy-like trajectories, consistent with tumor cell searching strategies. T-cells adjacent to tumor cells had reduced velocity and appeared to probe the local environment, consistent with cell-cell interactions. An increased number of T-cells were detected following treatment, traveling at lower mean velocities than controls, and demonstrating reduced displacement consistent with target engagement. Histogram-based analysis of immunofluorescent images from harvested tumors showed that in the ICI-treated mice there was a higher density of CD31+ vessels compared to untreated controls and a greater infiltration of T-cells towards the tumor core, consistent with increased cellular trafficking post-treatment
Generalized parton distributions in the deuteron
We introduce generalized quark and gluon distributions in the deuteron, which
can be measured in exclusive processes like deeply virtual Compton scattering
and meson electroproduction. We discuss the basic properties of these
distributions, and point out how they probe the interplay of nucleon and parton
degrees of freedom in the deuteron wave function
A precise measurement of the deuteron elastic structure function A(Q^2)
The A(Q^2) structure function in elastic electron-deuteron scattering was
measured at six momentum transfers Q^2 between 0.66 and 1.80 (GeV/c)^2 in Hall
C at Jefferson Laboratory. The scattered electrons and recoil deuterons were
detected in coincidence, at a fixed deuteron angle of 60.5 degrees. These new
precise measurements resolve discrepancies between older sets of data. They put
significant constraints on existing models of the deuteron electromagnetic
structure, and on the strength of isoscalar meson exchange currents.Comment: 3 LaTeX pages plus 2 PS figure
Measurement of Tensor Polarization in Elastic Electron-Deuteron Scattering at Large Momentum Transfer
Tensor polarization observables (t20, t21 and t22) have been measured in
elastic electron-deuteron scattering for six values of momentum transfer
between 0.66 and 1.7 (GeV/c)^2. The experiment was performed at the Jefferson
Laboratory in Hall C using the electron HMS Spectrometer, a specially designed
deuteron magnetic channel and the recoil deuteron polarimeter POLDER. The new
data determine to much larger Q^2 the deuteron charge form factors G_C and G_Q.
They are in good agreement with relativistic calculations and disagree with
pQCD predictions.Comment: 5 pages, 4 figures, for associated informations, see
http://isnwww.in2p3.fr/hadrons/t20/t20_ang.html clarification about several
topics, one figure has been had, extraction of form factors use AQ
interpolation in our Q2 range onl
The HPS electromagnetic calorimeter
The Heavy Photon Search experiment (HPS) is searching for a new gauge boson, the so-called âheavy photon.â Through its kinetic mixing with the Standard Model photon, this particle could decay into an electron-positron pair. It would then be detectable as a narrow peak in the invariant mass spectrum of such pairs, or, depending on its lifetime, by a decay downstream of the production target. The HPS experiment is installed in Hall-B of Jefferson Lab. This article presents the design and performance of one of the two detectors of the experiment, the electromagnetic calorimeter, during the runs performed in 2015â2016. The calorimeter's main purpose is to provide a fast trigger and reduce the copious background from electromagnetic processes through matching with a tracking detector. The detector is a homogeneous calorimeter, made of 442 lead-tungstate (PbWO4) scintillating crystals, each read out by an avalanche photodiode coupled to a custom trans-impedance amplifier
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