260 research outputs found
Failures in apathy
This collection of cross-genre fictional short stories and attendant artist\u27s statement examines the results of disconnect and social marginalization on characters faced with complex social and personal situations. Various manifestations of apathy and failure are considered as the characters interact within a post-utopian society that offers little hope of betterment and is rife with social awkwardness and anxieties regarding interaction. Ultimately, the disconnect of apathy and the acceptance of a failure to connect with their lives are problematized for the characters of the work, as the thesis identifies the troubling way in which apathy and difficulty in social connectivity is overlooked in modern society
CarboraneâContaining Matrix Metalloprotease (MMP) Ligands as Candidates for Boron NeutronâCapture Therapy (BNCT)
Based on the previously reported potent and selective sulfone hydroxamate inhibitors SCâ76276, SCâ78080 (SDâ2590), and SCâ77964, potent MMP inhibitors have been designed and synthesized to append a boronârich carborane cluster by employing click chemistry to target tumor cells that are known to upregulate gelatinases. Docking against MMPâ2 suggests binding involving the hydroxamate zincâbinding group, key Hâbonds by the sulfone moiety with the peptide backbone residues Leu82 and Leu83, and a hydrophobic interaction with the deep P1â pocket. The more potent of the two triazole regioisomers exhibits an IC50 of 3.7â
nM versus MMPâ2 and IC50 of 46â
nM versus MMPâ9
Yield criteria for glaciotectonically deformed deposits
Most glaciotectonically deformed deposits, including varved clays and glacial tills, are characterised by cracks and fissures. This paper presents a method for describing the yield criteria for glacitectonically deformed cohesive deposits using a model of cracked geomaterial with isotropic or anisotropic matrix. The general representation of the limit conditions for anisotropic materials in plane-strain is used to determine the yield criterion. The yield criterion represents a convex, piece-wise surface in the three-dimensional stress space revealing explicitly global, plastic properties of the materials considered. An example of using proposed yield criteria to solve a bearing capacity problem of a strip foundation constructed on a glaciotectonically cracked layer is presented. The lower and upper-bound estimates of limit loads on the strip footing are given. The limit state analysis presented in this paper can be used to solve many other geotechnical engineering problems, for example, the stability of slopes and reinforced walls or the bearing capacity of pile foundations
Off-Diagonal Elements of the DeWitt Expansion from the Quantum Mechanical Path Integral
The DeWitt expansion of the matrix element M_{xy} = \left\langle x \right|
\exp -[\case{1}{2} (p-A)^2 + V]t \left| y \right\rangle, in
powers of can be made in a number of ways. For (the case of interest
when doing one-loop calculations) numerous approaches have been employed to
determine this expansion to very high order; when (relevant for
doing calculations beyond one-loop) there appear to be but two examples of
performing the DeWitt expansion. In this paper we compute the off-diagonal
elements of the DeWitt expansion coefficients using the Fock-Schwinger gauge.
Our technique is based on representing by a quantum mechanical path
integral. We also generalize our method to the case of curved space, allowing
us to determine the DeWitt expansion of \tilde M_{xy} = \langle x| \exp
\case{1}{2} [\case{1}{\sqrt {g}} (\partial_\mu - i
A_\mu)g^{\mu\nu}{\sqrt{g}}(\partial_\nu - i A_\nu) ] t| y \rangle by use of
normal coordinates. By comparison with results for the DeWitt expansion of this
matrix element obtained by the iterative solution of the diffusion equation,
the relative merit of different approaches to the representation of as a quantum mechanical path integral can be assessed. Furthermore, the
exact dependence of on some geometric scalars can be
determined. In two appendices, we discuss boundary effects in the
one-dimensional quantum mechanical path integral, and the curved space
generalization of the Fock-Schwinger gauge.Comment: 16pp, REVTeX. One additional appendix concerning end-point effects
for finite proper-time intervals; inclusion of these effects seem to make our
results consistent with those from explicit heat-kernel method
Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany
In our paper (1), we analyzed isolates from the Escherichia coli O104:H4 outbreaks in Germany and France in May to July 2011. We concluded that, although the German outbreak was larger, the German isolates represent a clade within the greater diversity of the French outbreak. We proposed several hypotheses to explain these findings, including that the lineage leading to the German outbreak went through a narrow bottleneck that purged diversity.
Guy et al. (2) report the genomes of eight additional E. coli O104:H4 isolates sampled from the German outbreak. By focusing on the numbers of SNPs in their samples, they suggest that the German outbreak is more diverse than we reported and is similar to the French outbreak.
In fact, Guy et al.âs data (2) strongly support our conclusion that the German outbreak represents a clade within the diversity
Standard Model Theory for the FCC-ee Tera-Z stage
The future 100-km circular collider FCC at CERN is planned to operate in one
of its modes as an electron-positron FCC-ee machine. We give an overview
comparing the theoretical status to the experimental demands of one of four
foreseen FCC-ee operating stages, Z-boson resonance energy physics, called the
FCC-ee Tera-Z stage for short. The FCC-ee Tera-Z will deliver the highest
integrated luminosities as well as very small systematic errors for a study of
the Standard Model (SM) with unprecedented precision. In fact, the FCC-ee
Tera-Z will allow the study of at least one more perturbative order in quantum
field theory compared to the LEP/SLC precision. The real problem is that the
present precision of theoretical calculations of the various SM observables
does not match that of the anticipated experimental measurements. The
bottle-necks to overcoming this situation are identified. In particular, the
issues of precise QED unfolding and the correct calculation of SM
pseudo-observables are critically reviewed. In an Executive Summary, we specify
which basic theoretical calculations are needed to meet the strong experimental
expectations at the FCC-ee Tera-Z. Several methods, techniques and tools needed
for higher-order multi-loop calculations are presented. By inspection of the
Z-boson partial and total decay width analyses, it is argued that at the
beginning of operation of the FCC-ee Tera-Z, the theory predictions may be
tuned to be precise enough not to limit the physics interpretation of the
measurements. This statement is based on anticipated progress in analytical and
numerical calculations of multi-loop and multi-scale Feynman integrals and on
the completion of two-loop electroweak radiative corrections to the SM
pseudo-observables this year. However, the above statement is conditional as
the theoretical issues demand a very dedicated and focused investment by the
community.Comment: Published versio
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