The roles of agricultural biodiversity in the McLaren Vale landscape

Douglas K. Bardsley, Elisa Palazzo, Nathanael D. Wiseman, and Randy Stringe

Geo-neutrinos: A systematic approach to uncertainties and correlations

Geo-neutrinos emitted by heat-producing elements (U, Th and K) represent a unique probe of the Earth interior. The characterization of their fluxes is subject, however, to rather large and highly correlated uncertainties. The geochemical covariance of the U, Th and K abundances in various Earth reservoirs induces positive correlations among the associated geo-neutrino fluxes, and between these and the radiogenic heat. Mass-balance constraints in the Bulk Silicate Earth (BSE) tend instead to anti-correlate the radiogenic element abundances in complementary reservoirs. Experimental geo-neutrino observables may be further (anti)correlated by instrumental effects. In this context, we propose a systematic approach to covariance matrices, based on the fact that all the relevant geo-neutrino observables and constraints can be expressed as linear functions of the U, Th and K abundances in the Earth's reservoirs (with relatively well-known coefficients). We briefly discuss here the construction of a tentative "geo-neutrino source model" (GNSM) for the U, Th, and K abundances in the main Earth reservoirs, based on selected geophysical and geochemical data and models (when available), on plausible hypotheses (when possible), and admittedly on arbitrary assumptions (when unavoidable). We use then the GNSM to make predictions about several experiments ("forward approach"), and to show how future data can constrain - a posteriori - the error matrix of the model itself ("backward approach"). The method may provide a useful statistical framework for evaluating the impact and the global consistency of prospective geo-neutrino measurements and Earth models.Comment: 17 pages, including 4 figures. To appear on "Earth, Moon, and Planets," Special Issue on "Neutrino Geophysics," Proceedings of Neutrino Science 2005 (Honolulu, Hawaii, Dec. 2005

Hints of theta_13>0 from global neutrino data analysis

Nailing down the unknown neutrino mixing angle theta_13 is one of the most important goals in current lepton physics. In this context, we perform a global analysis of neutrino oscillation data, focusing on theta_13, and including recent results [Neutrino 2008, Proceedings of the XXIII International Conference on Neutrino Physics and Astrophysics, Christchurch, New Zealand, 2008 (unpublished)]. We discuss two converging hints of theta_13>0, each at the level of ~1sigma: an older one coming from atmospheric neutrino data, and a newer one coming from the combination of solar and long-baseline reactor neutrino data. Their combination provides the global estimate sin^2(theta_13) = 0.016 +- 0.010 (1sigma), implying a preference for \theta_13>0 with non-negligible statistical significance (~90% C.L.). We discuss possible refinements of the experimental data analyses, which might sharpen such intriguing indication.Comment: Minor changes in the text. Matches published version in PR

Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report

Background: Mutations in lysyl-tRNA synthetase (KARS1), an enzyme that charges tRNA with the amino acid lysine in both the cytoplasm and mitochondria, have been associated thus far with autosomal recessive Charcot–Marie–Tooth type CMTRIB, hearing loss type DFNB89, and mitochondrial encephalohepatopathy (MEH) featuring neurodevelopmental disorders with microcephaly, white matter changes, and cardiac and hepatic failure in less than 30 patients. Case presentation: We report the clinical, biochemical and molecular findings of a 14-month-old girl with severe MEH compatible clinical features, profound sensorineural hearing loss, leopard spot retinopathy, pancytopenia, and advanced liver disease with portal hypertension leading to death at the age of 30 months. Conclusions: Whole exome sequencing identified two rare variants in KARS1 gene. Our report expands the allelic and clinical features of tRNA synthase disorders. Moreover, with our report we confirm the usefulness of WES as first tier diagnostic method in infants with complex multisystem phenotypes

The Impact of Formula Choice for the Management of Pediatric Cow's Milk Allergy on the Occurrence of Other Allergic Manifestations: The Atopic March Cohort Study

Objectives: To compare the impact of different formulas on the occurrence of other atopic manifestations and the time of immune tolerance acquisition. Study design: In a 36-month prospective cohort study, the occurrence of other atopic manifestations (eczema, urticaria, asthma, and rhinoconjunctivitis) and the time of immune tolerance acquisition were comparatively evaluated in immunoglobulin E–mediated children with cow's milk allergy (CMA) treated with extensively hydrolyzed casein formula containing the probiotic L. rhamnosus GG (EHCF + LGG), rice hydrolyzed formula, soy formula, extensively hydrolyzed whey formula (EHWF), or amino acid–based formula. Results: In total, 365 subjects were enrolled into the study, 73 per formula cohort. The incidence of atopic manifestations was 0.22 (Bonferroni-corrected 95% CI 0.09-0.34) in the EHCF + LGG cohort; 0.52 (0.37-0.67) in the rice hydrolyzed formula cohort; 0.58 (0.43-0.72) in the soy formula cohort; 0.51 (0.36-0.66) in the EHWF cohort; and 0.77 (0.64-0.89) in the amino acid–based formula cohort. The incidence of atopic manifestations in the rice hydrolyzed formula, soy formula, EHWF, and amino acid–based formula cohorts vs the EHCF + LGG cohort was always greater than the prespecified absolute difference of 0.25 at an alpha-level of 0.0125, with corresponding risk ratios of 2.37 (1.46-3.86, P < .001) for rice hydrolyzed formula vs EHCF + LGG; 2.62 (1.63-4.22, P < .001) for soy formula vs EHCF + LGG; 2.31 (1.42-3.77, P < .001) for EHWF vs EHCF + LGG; and 3.50 (2.23-5.49, P < .001) for amino acid–based formula vs EHCF + LGG. The 36-month immune tolerance acquisition rate was greater in the EHCF + LGG cohort. Conclusions: The use of EHCF + LGG for CMA treatment is associated with lower incidence of atopic manifestations and greater rate of immune tolerance acquisition

Probing Sterile Neutrino Parameters with Double Chooz, Daya Bay and RENO

In this work, we present a realistic analysis of the potential of the present-day reactor experiments Double Chooz, Daya Bay and RENO for probing the existence of sterile neutrinos. We present exclusion regions for sterile oscillation parameters for each of these experiments, using simulations with realistic estimates of systematic errors and detector resolutions, and compare the sterile parameter sensitivity regions we obtain with the existing bounds from other reactor experiments. We find that these experimental set-ups give significant bounds on the parameter \Theta_{ee} especially in the low sterile oscillation region 0.01 < \Delta m_{41}^2 < 0.05 eV^2. These bounds can add to our understanding of the sterile neutrino sector since there is still a tension in the allowed regions from different experiments for sterile parameters.Comment: 12 pages, 5 figure

Global analysis of neutrino masses, mixings and phases: entering the era of leptonic CP violation searches

We perform a global analysis of neutrino oscillation data, including high-precision measurements of the neutrino mixing angle theta_13 at reactor experiments, which have confirmed previous indications in favor of theta_13>0. Recent data presented at the Neutrino 2012 Conference are also included. We focus on the correlations between theta_13 and the mixing angle theta_23, as well as between theta_13 and the neutrino CP-violation phase delta. We find interesting indications for theta_23< pi/4 and possible hints for delta ~ pi, with no significant difference between normal and inverted mass hierarchy.Comment: Updated version, including recent data released at the Neutrino 2012 Conference. Some references adde

"Green oncology": a new paradigm for medical oncology

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