Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011

The two risk communications were associated with reductions in antipsychotic use, in ways which were compatible with marked differences in their content and dissemination. Further research is needed to ensure that the content and dissemination of regulatory risk communications is optimal, and to track their impact on intended and unintended outcomes. Although rates are falling, antipsychotic prescribing in dementia in Scotland remains unacceptably hig

Analytical Study of Diffusive Relativistic Shock Acceleration

Particle acceleration in relativistic shocks is studied analytically in the test-particle, small-angle scattering limit, for an arbitrary velocity-angle diffusion function D. Accurate analytic expressions for the spectral index s are derived using few (2-6) low-order moments of the shock-frame angular distribution. For isotropic diffusion, previous results are reproduced and justified. For anisotropic diffusion, s is shown to be sensitive to D, particularly downstream and at certain angles, and a wide range of s values is attainable. The analysis, confirmed numerically, can be used to test collisionless shock models and to observationally constrain D. For example, strongly forward- or backward-enhanced diffusion downstream is ruled out by GRB afterglow observations.Comment: 4 pages, 2 figures, PRL accepted, minor change

Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment.

BACKGROUND:Many premature infants with respiratory failure are deficient in surfactant, but the relationship to occurrence of bronchopulmonary dysplasia (BPD) is uncertain. METHODS:Tracheal aspirates were collected from 209 treated and control infants enrolled at 7-14 days in the Trial of Late Surfactant. The content of phospholipid, surfactant protein B, and total protein were determined in large aggregate (active) surfactant. RESULTS:At 24 h, surfactant treatment transiently increased surfactant protein B content (70%, p < 0.01), but did not affect recovered airway surfactant or total protein/phospholipid. The level of recovered surfactant during dosing was directly associated with content of surfactant protein B (r = 0.50, p < 0.00001) and inversely related to total protein (r = 0.39, p < 0.0001). For all infants, occurrence of BPD was associated with lower levels of recovered large aggregate surfactant, higher protein content, and lower SP-B levels. Tracheal aspirates with lower amounts of recovered surfactant had an increased proportion of small vesicle (inactive) surfactant. CONCLUSIONS:We conclude that many intubated premature infants are deficient in active surfactant, in part due to increased intra-alveolar metabolism, low SP-B content, and protein inhibition, and that the severity of this deficit is predictive of BPD. Late surfactant treatment at the frequency used did not provide a sustained increase in airway surfactant

Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence.

BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions. Indirect evidence suggests that low dopamine D2-type receptor availability in the striatum contributes to the propensity of these individuals to sacrifice long-term goals for short-term gain; however, this possibility has not been tested directly. We investigated whether striatal D2/D3 receptor availability is negatively correlated with the preference for smaller, more immediate rewards over larger, delayed alternatives among research participants who met DSM-IV criteria for methamphetamine (MA) dependence.MethodsFifty-four adults (n = 27 each: MA-dependent, non-user controls) completed the Kirby Monetary Choice Questionnaire, and underwent positron emission tomography scanning with [(18)F]fallypride.ResultsMA users displayed steeper temporal discounting (p = 0.030) and lower striatal D2/D3 receptor availability (p < 0.0005) than controls. Discount rate was negatively correlated with striatal D2/D3 receptor availability, with the relationship reaching statistical significance in the combined sample (r = -0.291, p = 0.016) and among MA users alone (r = -0.342, p = 0.041), but not among controls alone (r = -0.179, p = 0.185); the slopes did not differ significantly between MA users and controls (p = 0.5).ConclusionsThese results provide the first direct evidence of a link between deficient D2/D3 receptor availability and steep temporal discounting. This finding fits with reports that low striatal D2/D3 receptor availability is associated with a higher risk of relapse among stimulant users, and may help to explain why some individuals choose to continue using drugs despite knowledge of their eventual negative consequences. Future research directions and therapeutic implications are discussed

Adaptive Optics Images of Kepler Objects of Interest

All transiting planets are at risk of contamination by blends with nearby, unresolved stars. Blends dilute the transit signal, causing the planet to appear smaller than it really is, or produce a false positive detection when the target star is blended with eclipsing binary stars. This paper reports on high spatial-resolution adaptive optics images of 90 Kepler planetary candidates. Companion stars are detected as close as 0.1 arcsec from the target star. Images were taken in the near-infrared (J and Ks bands) with ARIES on the MMT and PHARO on the Palomar Hale 200-inch. Most objects (60%) have at least one star within 6 arcsec separation and a magnitude difference of 9. Eighteen objects (20%) have at least one companion within 2 arcsec of the target star; 6 companions (7%) are closer than 0.5 arcsec. Most of these companions were previously unknown, and the associated planetary candidates should receive additional scrutiny. Limits are placed on the presence of additional companions for every system observed, which can be used to validate planets statistically using the BLENDER method. Validation is particularly critical for low-mass, potentially Earth-like worlds, which are not detectable with current-generation radial velocity techniques. High-resolution images are thus a crucial component of any transit follow-up program.Comment: 9 pages, 4 figures, accepted to A

Mortal Kombat: the effects of violent video game play on males’ hostility and cardiovascular responding.

ABSTRACT We examined cardiovascular (CV) reactivity and hostility among 30 male undergraduates after either nonviolent (billiards) or 1 of 2 levels of violent videogame play. Violence varied among 2 versions of the game Mortal Kombat (MKl = less violent, MK2 = more violent)-all other factors (graphics, sound) were held equal. As expected, increased game violence elicited greater CV reactivity and higher scores on hostility measures. Subjects who played MK1 or MK2 had higher heart rate reactivity than those who played billiards. Subjects who played MK2 showed greater systolic blood pressure reactivity than those who played MKl or billiards. Finally, subjects who played MK2 scored higher on the hostility measures than those who played MKl, who in turn scored higher than those who played billiards. These results indicate that the level of videogame violence, not just violence per se, should be of concern to consumers

Regional cutaneous microvascular flow responses during gravitational and LBNP stresses

Due to the regional variability of local hydrostatic pressures, microvascular flow responses to gravitational stress probably vary along the length of the body. Although these differences in local autoregulation have been observed previously during whole-body tilting, they have not been investigated during application of artificial gravitational stresses, such as lower body negative pressure or high gravity centrifugation. Although these stresses can create equivalent G-levels at the feet, they result in distinct distributions of vascular transmural pressure along the length of the body, and should consequently elicit different magnitudes and distributions of microvascular response. In the present study, the effects of whole-body tilting and lower body negative pressure on the level and distribution of microvascular flows within skin along the length of the body were compared