Dielectric relaxation of the ionic liquid 1-ethyl-3-methylimidazolium ethyl sulfate: microwave and far-IR properties

Dielectric relaxation of the ionic liquid, 1-ethyl-3-methylimidazolium ethyl sulfate (EMI+ETS–), is studied using molecular dynamics (MD) simulations. The collective dynamics of polarization arising from cations and anions are examined. Characteristics of the rovibrational and translational components of polarization dynamics are analyzed to understand their respective roles in the microwave and terahertz regions of dielectric relaxation. The MD results are compared with the experimental low-frequency spectrum of EMI+ETS–, obtained via ultrafast optical Kerr effect (OKE) measurements

Removal of Confined Ionic Liquid from a Metal Organic Framework by Extraction with Molecular Solvents

This work was supported in part by NSF Grant No. CHE-1223988 and by EPSRC Grant No. EP/K00090X/1.Peer reviewedPostprin

Ispitivanje vosku sličnih svojstava ibuprofena kao veziva

The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr’s index, Hausner’s ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation techniqueSvrha rada je ispitivanje vosku sličnih svojstava ibuprofena, tvari s višeznačnom funkcijom (ljekovita tvar i vezivo pri granulaciji). Vezivna svojstva uspoređivana su s granulama pripravljenim vlažnom granulacijom s polivinilpirolidonom (PVP K-30) kao vezivom, ispitivanjem mikrometričkih, fizikalnih i mehaničkih svojstava kao što su sipkost materijala, Carrov indeks distribucije veličine čestica, Hausnerov parameter, otpornost na vlak. Da bi se ispitala distribucija veziva tijekom granulacije taljenjem određivana je ujednačenost sadržaja. Za praćenje promjena fizikalnih svojstava ibuprofena snimljeni su XRPD, DSC, FTIR spektri. Istraživanja ukazuju da se ibuprofen može koristiti kao vezivo u ljekovitim pripravcima ibuprofena u kojima se primjenjuje granulacija taljenjem

Molecular Interactions of a Cu-Based Metal-Organic Framework with a Confined Imidazolium-Based Ionic Liquid : A Combined Density Functional Theory and Experimental Vibrational Spectroscopy Study

This work was supported in part by NSF Grant CHE-1223988 and by EPSRC Grant EP/K00090X/1.Peer reviewedPublisher PD

Ispitivanje vosku sličnih svojstava ibuprofena kao veziva

The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr’s index, Hausner’s ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation techniqueSvrha rada je ispitivanje vosku sličnih svojstava ibuprofena, tvari s višeznačnom funkcijom (ljekovita tvar i vezivo pri granulaciji). Vezivna svojstva uspoređivana su s granulama pripravljenim vlažnom granulacijom s polivinilpirolidonom (PVP K-30) kao vezivom, ispitivanjem mikrometričkih, fizikalnih i mehaničkih svojstava kao što su sipkost materijala, Carrov indeks distribucije veličine čestica, Hausnerov parameter, otpornost na vlak. Da bi se ispitala distribucija veziva tijekom granulacije taljenjem određivana je ujednačenost sadržaja. Za praćenje promjena fizikalnih svojstava ibuprofena snimljeni su XRPD, DSC, FTIR spektri. Istraživanja ukazuju da se ibuprofen može koristiti kao vezivo u ljekovitim pripravcima ibuprofena u kojima se primjenjuje granulacija taljenjem

Comparative study of hyperbaric 0.5% bupivacaine and hyperbaric 0.5% bupivacaine with low dose dexmedetomidine in spinal anaesthesia

Background: Spinal anaesthesia remains one of the basic techniques in the arsenal of modern anaesthesiology despite the waxing and waning of its popularity over last 100 years since its introduction into clinical practice.It avoids biochemical and metabolic changes consequent to the stress of general anesthesia for surgery as well as provides near optimal conditions for surgery. In present study, we tried to study effectiveness of intrathecal 0.5% heavy bupivacaine alone with Dexmedetomidine as an adjuvant to intrathecal 0.5% heavy bupivacaine for lower limb and lower abdominal surgeries.Methods: The present study was conducted in the department of anaesthesiology from December 2011 to September 2013.This study was a prospective, randomised controlled, single blind, study conducted in 100 patients of ASA grade I and II undergoing elective surgeries under spinal anaesthesia. The patients were divided randomly into two groups, containing 50 patients in each group. Dosages of drugs selected are divided as Group B: Patients received 3 ml of 0.5% hyperbaric bupivacaine (15mg) and Group BD: Patients received 3 ml of 0.5% hyperbaric bupivacaine (15mg) plus 10 µg Dexmedetomidine. Spinal block characteristics, Mean arterial pressure, Mean pulse rate, sedation and side effects were studied during intra-operative and postoperative period.Results: It was found from present study that in Dexmedetomidine group time to reach T10 sensory blockade and complete motor blockade was earlier and a higher level of sensory blockade compared to control group achieved. Duration of sensory, motor blockade and duration of analgesia was significantly prolonged in the Dexmedetomidine group compared to the control group. Hemodynamic parameters were preserved both intra-operatively and postoperatively. However there were a small percentage of patients who developed hypotension and bradycardia which were easily managed without any untoward effect. Hence Dexmedetomidine is a better neuraxial adjuvant for providing early onset of sensory and motor blockade, prolonged sensory blockade and post operative analgesia and adequate sedation.Conclusions: Intrathecal low dose Dexmedetomidine in a dose of 10µg along with 0.5% hyperbaric bupivacaine is an addition into anaesthesiologist's armamentarium for spinal anaesthesia in patients undergoing elective lower abdominal and lower limb surgeries

Seed germination and seedling physiology of ajowan (Trachyspermum ammi L.) under chloride salinity

Seed germination and seedling physiology of ajowan (Trachyspermum ammi) was investigated under salinity induced by NaCl. Five different salinity levels (0, 25, 50, 100 and 150 mM) were used. The results revealed that seed germination and seedling growth were significantly retarded due to salinity. Significant accumulation of various osmolytes like reducing sugars and total sugars, proline, glycine betaine and total free amino acids was recorded with increasing salinity. The reduction in protein and starch content of seedlings under stress condition was concentration dependent. The studies suggested that ajowan is moderately tolerant to salt stress at seed germination stage. &nbsp

Effect of Different Extraction Conditions on Total Alkaloids, Total Phenolic and Total Flavonoid Content of Vigna mungo L hepper

Vigna mungo L Hepper is an important pulse crop cultivated in India. It is rich source of many nutritional compounds and it is an integral part of diet. Bioactive compounds like phenolic, alkaloids, flavonoids, saponins etc. are present in the seeds. Objective is to determine the content of bioactive compounds present in the black gram seeds and to study effect of sample pretreatment, fractionation on total alkaloid, total phenolic and total flavonoids content. Three types of extracts were prepared by using ethanol as a solvent by using Soxhlet extractor. First Ethanolic extract (EE), second extract prepared from pretreated seeds with an acid (EEH) and third fraction from ethanolic extract (EF) were prepared. Total alkaloid content were determined spectrophometrically by using Bromocresol green using Atropine as a standard. Total phenolic content was estimated spectrophometrically by using Gallic acid as a standard. Quercetin was used as a standard for estimation of total flavonoids content. The total phenolic content of the EE, EF and EEH extract, was 20.0 ± 5.28, 21.03±5.04 and 17.8±5.77 Gallic acid equivalents/g respectively. The total flavonoid content of EE, EF and EEH extract was 166.7± 3.66, 304.2 ±3.48 and 112.5± 3.95 quercetin equivalents/g. The total alkaloid content of EE, EF and EEH extract, was 121.9±3.77, 154.8±3.60 and 202.1±3.49 Atropine equivalents/g. various treatments have effect on extraction of bioactive compounds. Extract from pretreated seeds with acid improved extraction of alkaloids. Fractionation of extract yield higher content of flavonoids and phenolic content than normal ethanolic extract. Hydrolysis of extract results in decreased concentration of flavonoids and phenolic. Keywords: Alkaloid, Bioactive, Flavonoids, Phenolic, Vigna mung

Tomato (Solanum lycopersicum L.) seed : a review on bioactives and biomedical activities

The processing of tomato fruit into puree, juices, ketchup, sauces, and dried powders generates a significant amount of waste in the form of tomato pomace, which includes seeds and skin. Tomato processing by-products, particularly seeds, are reservoirs of health-promoting macromolecules, such as proteins (bioactive peptides), carotenoids (lycopene), polysaccharides (pectin), phytochemicals (flavonoids), and vitamins (α-tocopherol). Health-promoting properties make these bioactive components suitable candidates for the development of novel food and nutraceutical products. This review comprehensively demonstrates the bioactive compounds of tomato seeds along with diverse biomedical activities of tomato seed extract (TSE) for treating cardiovascular ailments, neurological disorders, and act as antioxidant, anticancer, and antimicrobial agent. Utilization of bioactive components can improve the economic feasibility of the tomato processing industry and may help to reduce the environmental pollution generated by tomato by-products