994 research outputs found
Drama teacher education, partnerships for transforming the future: Exploring the concepts of building a Guild of Drama Educators
Focus: The concept of drama teacher education as catalyst for creating communities of drama educators– drama education as an induction into a community of drama educator
Report of the x ray and gamma ray sensors panel
Overall five major areas of technology are recommended for development in order to meet the science requirements of the Astrotech 21 mission set. These are: detectors for high resolution gamma ray spectroscopy, cryogenic detectors for improved x ray spectral and spatial resolution, advanced x ray charge coupled devices (CCDs) for higher energy resolution and larger format, extension to higher energies, liquid and solid position sensitive detectors for improving stopping power in the energy range 5 to 500 keV and 0.2 to 2 MeV. Development plans designed to achieve the desired capabilities on the time scales required by the technology freeze dates have been recommended in each of these areas
An X-ray view of the hot circum-galactic medium
The hot circum- galactic medium (CGM) represents the hot gas distributed beyond the stellar content of the galaxies while typically within their dark matter halos. It serves as a depository of energy and metal- enriched materials from galactic feedback and a reservoir from which the galaxy acquires fuels to form stars. It thus plays a critical role in the coevolution of galaxies and their environments. X- rays are one of the best ways to trace the hot CGM. I will briefly review what we have learned about the hot CGM based on X- ray observations over the past two decades, and what we still do not know. I will also briefly prospect what may be the foreseeable breakthrough in the next one or two decades with future X- ray missions.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154643/1/asna202023775.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154643/2/asna202023775_am.pd
Novel cruzain inhibitors for the treatment of Chagas' disease.
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas' disease, affects millions of individuals and continues to be an important global health concern. The poor efficacy and unfavorable side effects of current treatments necessitate novel therapeutics. Cruzain, the major cysteine protease of T. cruzi, is one potential novel target. Recent advances in a class of vinyl sulfone inhibitors are encouraging; however, as most potential therapeutics fail in clinical trials and both disease progression and resistance call for combination therapy with several drugs, the identification of additional classes of inhibitory molecules is essential. Using an exhaustive virtual-screening and experimental validation approach, we identify several additional small-molecule cruzain inhibitors. Further optimization of these chemical scaffolds could lead to the development of novel drugs useful in the treatment of Chagas' disease
Seismic Safety Retrofit of Second Narrows Bridge Foundations Geotechnical Design Aspects
The geotechnical engineering analyses carried out for the seismic safety retrofit design of Second Narrows Bridge located in Vancouver, Canada, are presented. The work involved detailed ground response analyses to evaluate the liquefaction potential of site soils, the development of a series of numerical models to assess the pattern and magnitude of liquefaction-induced ground displacements, and to analytically evaluate the ground displacements with potential ground improvements
Searching for keV Sterile Neutrino Dark Matter with X-ray Microcalorimeter Sounding Rockets
High-resolution X-ray spectrometers onboard suborbital sounding rockets can
search for dark matter candidates that produce X-ray lines, such as decaying
keV-scale sterile neutrinos. Even with exposure times and effective areas far
smaller than XMM-Newton and Chandra observations, high-resolution, wide
field-of-view observations with sounding rockets have competitive sensitivity
to decaying sterile neutrinos. We analyze a subset of the 2011 observation by
the X-ray Quantum Calorimeter instrument centered on Galactic coordinates l =
165, b = -5 with an effective exposure of 106 seconds, obtaining a limit on the
sterile neutrino mixing angle of sin^2(2 theta) < 7.2e-10 at 95% CL for a 7 keV
neutrino. Better sensitivity at the level of sin^2(2 theta) ~ 2.1e-11 at 95\%
CL for a 7 keV neutrino is achievable with future 300-second observations of
the galactic center by the Micro-X instrument, providing a definitive test of
the sterile neutrino interpretation of the reported 3.56 keV excess from galaxy
clusters.Comment: 13 pages, 13 figures, submitted to Ap
Coupling nonpolar and polar solvation free energies in implicit solvent models
Recent studies on the solvation of atomistic and nanoscale solutes indicate
that a strong coupling exists between the hydrophobic, dispersion, and
electrostatic contributions to the solvation free energy, a facet not
considered in current implicit solvent models. We suggest a theoretical
formalism which accounts for coupling by minimizing the Gibbs free energy of
the solvent with respect to a solvent volume exclusion function. The resulting
differential equation is similar to the Laplace-Young equation for the
geometrical description of capillary interfaces, but is extended to microscopic
scales by explicitly considering curvature corrections as well as dispersion
and electrostatic contributions. Unlike existing implicit solvent approaches,
the solvent accessible surface is an output of our model. The presented
formalism is illustrated on spherically or cylindrically symmetrical systems of
neutral or charged solutes on different length scales. The results are in
agreement with computer simulations and, most importantly, demonstrate that our
method captures the strong sensitivity of solvent expulsion and dewetting to
the particular form of the solvent-solute interactions.Comment: accpted in J. Chem. Phy
Observed Limits on Charge Exchange Contributions to the Diffuse X-ray Background
We present a high resolution spectrum of the diffuse X-ray background from
0.1 to 1 keV for a ~1 region of the sky centered at l=90, b=+60 using a
36-pixel array of microcalorimeters flown on a sounding rocket. With an energy
resolution of 11 eV FWHM below 1 keV, the spectrum's observed line ratios help
separate charge exchange contributions originating within the heliosphere from
thermal emission of hot gas in the interstellar medium. The X-ray sensitivity
below 1 keV was reduced by about a factor of four from contamination that
occurred early in the flight, limiting the significance of the results. The
observed centroid of helium-like O VII is 568+2-3 eV at 90% confidence. Since
the centroid expected for thermal emission is 568.4 eV while for charge
exchange is 564.2 eV, thermal emission appears to dominate for this line
complex, consistent with much of the high-latitude O VII emission originating
in 2-3 x 10^6 K gas in the Galactic halo. On the other hand, the observed ratio
of C VI Ly gamma to Ly alpha is 0.3+-0.2. The expected ratios are 0.04 for
thermal emission and 0.24 for charge exchange, indicating that charge exchange
must contribute strongly to this line and therefore potentially to the rest of
the ROSAT R12 band usually associated with 10^6 K emission from the Local Hot
Bubble. The limited statistics of this experiment and systematic uncertainties
due to the contamination require only >32% thermal emission for O VII and >20%
from charge exchange for C VI at the 90% confidence level. An experimental gold
coating on the silicon substrate of the array greatly reduced extraneous
signals induced on nearby pixels from cosmic rays passing through the
substrate, reducing the triggered event rate by a factor of 15 from a previous
flight of the instrument.Comment: 14 pages, 7 figures, to be published in Ap
The Ionization of the Local Interstellar Medium, as Revealed by FUSE Observations of N, O and Ar toward White Dwarf Stars
FUSE spectra of the white dwarf stars G191-B2B, GD 394, WD 2211-495 and WD
2331-475 cover the absorption features out of the ground electronic states of N
I, N II, N III, O I and Ar I in the far ultraviolet, providing new insights on
the origin of the partial ionization of the Local Interstellar Medium (LISM),
and for the case of G191-B2B, the interstellar cloud that immediately surrounds
the solar system. Toward these targets the interstellar abundances of Ar I, and
sometimes N I, are significantly below their cosmic abundances relative to H I.
In the diffuse interstellar medium, these elements are not likely to be
depleted onto dust grains. Generally, we expect that Ar should be more strongly
ionized than H (and also O and N whose ionizations are coupled to that of H via
charge exchange reactions) because the cross section for the photoionization of
Ar I is very high. Our finding that Ar I/H I is low may help to explain the
surprisingly high ionization of He in the LISM found by other investigators.
Our result favors the interpretation that the ionization of the local medium is
maintained by a strong EUV flux from nearby stars and hot gases, rather than an
incomplete recovery from a past, more highly ionized condition.Comment: 13 pages, 2 figures. To appear in a special issue of the
Astrophysical Journal Letters devoted to the first scientific results from
the FUSE missio
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Dispersion-reduction technique using subcarrier multiplexing
We have developed a novel dispersion-reduction technique using subcarrier multiplexing (SCM) which permits the transmission of multiple 2.5 Gbit/s data channels over hundreds of kilometers of conventional fiber-optic cable with negligible dispersion. Using a lithium niobate external modulator having a modulation bandwidth of 20 GHz, we are able to multiplex several high-speed data channels at a single wavelength. At the receiving end, we demultiplex the data and detect each channel using a 2-GHz bandwidth optical detector. All of the hardware in our system consists of off-the-shelf components and can be integrated to reduce the overall cost. We demonstrated our dispersion-reduction technique in a recent field trial by transmitting two 2.5 Gbit/s data channels over 90 km of commercially-installed single-mode fiber, followed by 210 km of spooled fiber. For comparison, we substituted the 300 km of fiber with equivalent optical attenuation. We also ran computer simulations to evaluate link behavior. Technical details and field trial results will be presented
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