Identification and temporal behavior of radical intermediates formed during the combustion and pyrolysis of gaseous fuels: Kinetic pathways to soot formation. Final performance report, July 1, 1994--June 30, 1997

The authors have developed software in-house to automate the processing of peak heights recorded from the shock tube: time-of-flight mass spectrometer (TOF) experiments in a format suitable for the modeling programs and have performed numerous ab initio calculations to provide energy barrier values and thermodynamic data for several key reactions in various reaction mechanisms. Each of the studies described here has contributed to the understanding of the detailed kinetics of the reactions of acyclic fuels, the thermal decompositions of aromatic ring compounds, the shock tube techniques dedicated to combustion science problems, and the role of theoretical chemistry in providing essential thermodynamic and kinetics information necessary for constructing plausible reaction mechanisms. The knowledge derived from these investigations is applicable not only to the area of pre-particle soot formation chemistry, but also to various incineration and coal pyrolysis problems

Satellite passive microwave sea-ice concentration data set inter-comparison for Arctic summer conditions

We report on results of a systematic inter-comparison of 10 global sea-ice concentration (SIC) data products at 12.5 to 50.0 km grid resolution from satellite passive microwave (PMW) observations for the Arctic during summer. The products are compared against SIC and net ice surface fraction (ISF) - SIC minus the per-grid-cell melt pond fraction (MPF) on sea ice - as derived from MODerate resolution Imaging Spectroradiometer (MODIS) satellite observations and observed from ice-going vessels. Like in Kern et al. (2019), we group the 10 products based on the concept of the SIC retrieval used. Group I consists of products of the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) Ocean and Sea Ice Satellite Application Facility (OSI SAF) and European Space Agency (ESA) Climate Change Initiative (CCI) algorithms. Group II consists of products derived with the Comiso bootstrap algorithm and the National Oceanographic and Atmospheric Administration (NOAA) National Snow and Ice Data Center (NSIDC) SIC climate data record (CDR). Group III consists of Arctic Radiation and Turbulence Interaction Study (ARTIST) Sea Ice (ASI) and National Aeronautics and Space Administration (NASA) Team (NT) algorithm products, and group IV consists of products of the enhanced NASA Team algorithm (NT2). We find widespread positive and negative differences between PMW and MODIS SIC with magnitudes frequently reaching up to 20 %-25 % for groups I and III and up to 30 %-35 % for groups II and IV. On a pan-Arctic scale these differences may cancel out: Arctic average SIC from group I products agrees with MODIS within 2 %-5 % accuracy during the entire melt period from May through September. Group II and IV products overestimate MODIS Arctic average SIC by 5 %-10 %. Out of group III, ASI is similar to group I products while NT SIC underestimates MODIS Arctic average SIC by 5 %-10 %. These differences, when translated into the impact computing Arctic sea-ice area (SIA), match well with the differences in SIA between the four groups reported for the summer months by Kern et al. (2019). MODIS ISF is systematically overestimated by all products; NT provides the smallest overestimations (up to 25 %) and group II and IV products the largest overestimations (up to 45 %). The spatial distribution of the observed overestimation of MODIS ISF agrees reasonably well with the spatial distribution of the MODIS MPF and we find a robust linear relationship between PMW SIC and MODIS ISF for group I and III products during peak melt, i.e. July and August. We discuss different cases taking into account the expected influence of ice surface properties other than melt ponds, i.e. wet snow and coarse-grained snow/refrozen surface, on brightness temperatures and their ratios used as input to the SIC retrieval algorithms. Based on this discussion we identify the mismatch between the actually observed surface properties and those represented by the ice tie points as the most likely reason for (i) the observed differences between PMW SIC and MODIS ISF and for (ii) the often surprisingly small difference between PMW and MODIS SIC in areas of high melt pond fraction. We conclude that all 10 SIC products are highly inaccurate during summer melt. We hypothesize that the unknown number of melt pond signatures likely included in the ice tie points plays an important role - particularly for groups I and II - and recommend conducting further research in this field

A generalization of the van-der-Pol oscillator underlies active signal amplification in Drosophila hearing

The antennal hearing organs of the fruit fly Drosophila melanogaster boost their sensitivity by an active mechanical process that, analogous to the cochlear amplifier of vertebrates, resides in the motility of mechanosensory cells. This process nonlinearly improves the sensitivity of hearing and occasionally gives rise to self-sustained oscillations in the absence of sound. Time series analysis of self-sustained oscillations now unveils that the underlying dynamical system is well described by a generalization of the van-der-Pol oscillator. From the dynamic equations, the underlying amplification dynamics can explicitly be derived. According to the model, oscillations emerge from a combination of negative damping, which reflects active amplification, and a nonlinear restoring force that dictates the amplitude of the oscillations. Hence, active amplification in fly hearing seems to rely on the negative damping mechanism initially proposed for the cochlear amplifier of vertebrate

(Meta-)stable reconstructions of the diamond(111) surface: interplay between diamond- and graphite-like bonding

Off-lattice Grand Canonical Monte Carlo simulations of the clean diamond (111) surface, based on the effective many-body Brenner potential, yield the $(2\times1)$ Pandey reconstruction in agreement with \emph{ab-initio} calculations and predict the existence of new meta-stable states, very near in energy, with all surface atoms in three-fold graphite-like bonding. We believe that the long-standing debate on the structural and electronic properties of this surface could be solved by considering this type of carbon-specific configurations.Comment: 4 pages + 4 figures, Phys. Rev. B Rapid Comm., in press (15Apr00). For many additional details (animations, xyz files) see electronic supplement to this paper at http://www.sci.kun.nl/tvs/carbon/meta.htm

Microphase morphology in two dimensional fluids under lateral confinement

We study the effects of confinement between two parallel walls on a two dimensional fluid with competing interactions which lead to the formation of particle micro-domains at the thermodynamic equilibrium (microphases or microseparation). The possibility to induce structural changes of the morphology of the micro-domains is explored, under different confinement conditions and temperatures. In presence of neutral walls, a switch from stripes of particles to circular clusters (droplets) occurs as the temperature decreases, which does not happen in bulk. While the passage from droplets to stripes, as the density increases, is a well known phenomenon, the change of the stripes into droplets as an effect of temperature is rather unexpected. Depending on the wall separation and on the wall-fluid interaction parameters, the stripes can switch from parallel to perpendicular to the walls and also a mixed morphology can be stable.Comment: accepted by Physical Review E (rapid communications

Effects of Fluorescein Staining on Laser In Vivo Confocal Microscopy Images of the Cornea

This study was designed to identify whether topical fluorescein, a common ophthalmic tool, affects laser in vivo confocal microscopy of the cornea, a tool with growing applications. Twenty-five eye care specialists were asked to identify presence or absence of fluorescein in 99 confocal micrographs of healthy corneas. Responses were statistically similar to guessing for the epithelium (48% ± 14% of respondents correct per image) and the subbasal nerve plexus (49% ± 11% correct), but results were less clear for the stroma. Dendritic immune cells were quantified in bilateral images from subjects who had been unilaterally stained with fluorescein. Density of dendritic immune cells was statistically similar between the unstained and contralateral stained eyes of 24 contact lens wearers (P = .72) and of 10 nonwearers (P = .53). Overall, the results indicated that fluorescein staining did not interfere with laser confocal microscopy of corneal epithelium, subbasal nerves, or dendritic immune cells

GC-Biased Evolution Near Human Accelerated Regions

Regions of the genome that have been the target of positive selection specifically along the human lineage are of special importance in human biology. We used high throughput sequencing combined with methods to enrich human genomic samples for particular targets to obtain the sequence of 22 chromosomal samples at high depth in 40 kb neighborhoods of 49 previously identified 100–400 bp elements that show evidence for human accelerated evolution. In addition to selection, the pattern of nucleotide substitutions in several of these elements suggested an historical bias favoring the conversion of weak (A or T) alleles into strong (G or C) alleles. Here we found strong evidence in the derived allele frequency spectra of many of these 40 kb regions for ongoing weak-to-strong fixation bias. Comparison of the nucleotide composition at polymorphic loci to the composition at sites of fixed substitutions additionally reveals the signature of historical weak-to-strong fixation bias in a subset of these regions. Most of the regions with evidence for historical bias do not also have signatures of ongoing bias, suggesting that the evolutionary forces generating weak-to-strong bias are not constant over time. To investigate the role of selection in shaping these regions, we analyzed the spatial pattern of polymorphism in our samples. We found no significant evidence for selective sweeps, possibly because the signal of such sweeps has decayed beyond the power of our tests to detect them. Together, these results do not rule out functional roles for the observed changes in these regions—indeed there is good evidence that the first two are functional elements in humans—but they suggest that a fixation process (such as biased gene conversion) that is biased at the nucleotide level, but is otherwise selectively neutral, could be an important evolutionary force at play in them, both historically and at present