The Orphan Drug Act and the Development of Stem Cell-Based Products for Rare Diseases

The Orphan Drug Act encourages the development of products for rare diseases and conditions. Many conditions that stand to benefit from stem cell-based products are rare diseases. We address the Orphan Drug Act in relation to the development of stem cell-based products

Orientation of the Stripe Formed by the Two-Dimensional Electrons in Higher Landau Levels

Effect of periodic potential on the stripe phase realized in the higher Landau levels is investigated by the Hartree-Fock approximation. The period of the potential is chosen to be two to six times of the fundamental period of the stripe phase. It is found that the stripe aligns perpendicularly to the external potential in contrast to a naive expectation and hydrodynamic theory. Charge modulation towards the Wigner crystallization along the stripe is essential for the present unexpected new result.Comment: 5 pages, RevTex, two figures included in the tex

Static Properties of Trapped Bose-Fermi Mixed Condensate of Alkali Atoms

Static properties of a bose-fermi mixture of trapped potassium atoms are studied in terms of coupled Gross-Pitaevskii and Thomas-Fermi equations for both repulsive and attractive bose-fermi interatomic potentials. Qualitative estimates are given for solutions of the coupled equations, and the parameter regions are obtained analytically for the boson-density profile change and for the boson/fermion phase separation. Especially, the parameter ratio $R_{int}$ is found that discriminates the region of the large boson-profile change. These estimates are applied for numerical results for the potassium atoms and checked their consistency. It is suggested that a small fraction of fermions could be trapped without an external potential for the system with an attractive boson-fermion interaction.Comment: 8 pages,5 figure

Physician-Controlled Wire-Guided Cannulation of the Minor Papilla

Background. Minor papilla (MiP) cannulation is frequently performed using specialized small-caliber accessories. Outcomes data for MiP cannulation with standard-sized accessories are lacking. Methods. This is a case series describing MiP cannulation outcomes in consecutive patients treated by two endoscopists between July 2005 and November 2008 at two tertiary referral centers. MiP cannulation was attempted using a 4.4 Fr tip sphincterotome loaded with a 0.035″, 260 cm hydrophilic-tip guidewire, using a wire-guided technique under physician control. Results. 25 patients were identified (14 women, mean age 45). Procedure indications included recurrent acute pancreatitis in 16 patients (64%) and chronic pancreatitis in 2 (8%), among other indications. MiP cannulation was successful in 24 patients (96%). Sphincterotomy followed by pancreatic stent placement was performed in 21 patients (84%). Mild post-ERCP pancreatitis occurred in 3 patients (12%). Conclusion. Physician-controlled wire-guided MiP cannulation using a 4.4 Fr sphincterotome and 0.035″ guidewire is an effective and safe technique

Nucleosynthesis imprints from different Type Ia Supernova explosion scenarios and implications for galactic chemical evolution

We analyze the nucleosynthesis yields of various Type Ia supernova explosion simulations including pure detonations in sub- Chandrasekhar mass white dwarfs, double detonations and pure helium detonations of sub-Chandrasekhar mass white dwarfs with an accreted helium envelope, a violent merger model of two white dwarfs and deflagrations as well as delayed detonations in Chandrasekhar mass white dwarfs. We focus on the iron peak elements Mn, Zn and Cu. To this end, we also briefly review the different burning regimes and production sites of these elements as well as the results of abundance measurements and several galactic chemical evolution studies. We find that super-solar values of [Mn/Fe] are not restricted to Chandrasekhar mass explosion models. Scenarios including a helium detonation can significantly contribute to the production of Mn, in particular the models proposed for calcium-rich transients. Although Type Ia supernovae are often not accounted for as production sites of Zn and Cu, our models involving helium shell detonations can produce these elements in super-solar ratios relative to Fe. Our results suggest a re-consideration of Type Ia supernova yields in galactic chemical evolution models. A detailed comparison with observations can provide new insight into the progenitor and explosion channels of these events.Comment: 15 paged, 8 figures, accepted for publication in A&

The Infrared Continuum Sizes of Be Star Disks

We present an analysis of the near-infrared continuum emission from the circumstellar gas disks of Be stars using a radiative transfer code for a parametrized version of the viscous decretion disk model. This isothermal gas model creates predicted images that we use to estimate the HWHM emission radius along the major axis of the projected disk and the spatially integrated flux excess at wavelengths of 1.7, 2.1, 4.8, 9, and 18 ?m. We discuss in detail the effect of the disk base density, inclination angle, stellar effective temperature, and other physical parameters on the derived disk sizes and color excesses. We calculate color excess estimates relative to the stellar V -band flux for a sample of 130 Be stars using photometry from 2MASS and the AKARI infrared camera all-sky survey. The color excess relations from our models make a good match of the observed color excesses of Be stars. We also present our results on the projected size of the disk as a function of wavelength for the classical Be star ? Tauri, and we show that the model predictions are consistent with interferometric observations in the H, K', and 12 \mu m bands

Thermodynamic Phase Diagram of the Quantum Hall Skyrmion System

We numerically study the interacting quantum Hall skyrmion system based on the Chern-Simons action. By noticing that the action is invariant under global spin rotations in the spin space with respect to the magnetic field direction, we obtain the low-energy effective action for a many skyrmion system. Performing extensive molecular dynamics simulations, we establish the thermodynamic phase diagram for a many skyrmion system.Comment: 4 pages, RevTex, 2 postscript figure

An atlas of 2.4 to 4.1 microns ISO/SWS spectra of early-type stars

We present an atlas of spectra of O- and B-type stars, obtained with the Short Wavelength Spectrometer (SWS) during the Post-Helium program of the Infrared Space Observatory (ISO). This program is aimed at extending the Morgan & Keenan classification scheme into the near-infrared. Later type stars will be discussed in a seperate publication. The observations consist of 57 SWS Post-Helium spectra from 2.4 to 4.1 microns, supplemented with 10 spectra acquired during the nominal mission with a similar observational setting. For B-type stars, this sample provides ample spectral converage in terms of subtype and luminosity class. For O-type stars,the ISO sample is coarse and therefore is complemented with 8 UKIRT L'-band observations. In terms of the presence of diagnostic lines, the L'-band is likely the most promising of the near-infrared atmospheric windows for the study of the physical properties of B stars. Specifically, this wavelength interval contains the Brackett alpha, Pfund gamma, and other Pfund lines which are probes of spectral type, luminosity class and mass loss. Here, we present simple empirical methods based on the lines present in the 2.4 to 4.1 microns interval that allow the determination of: the spectral type of B dwarfs and giants to within two subtypes; the luminosity class of B stars to within two classes; the mass-loss rate of O stars and B supergiants to within 0.25 dex.Comment: 19 pages, 11 Postscript figures, accepted by A&

Collective Modes of Soliton-Lattice States in Double-Quantum-Well Systems

In strong perpendicular magnetic fields double-quantum-well systems can sometimes occur in unusual broken symmetry states which have interwell phase coherence in the absence of interwell hopping. When hopping is present in such systems and the magnetic field is tilted away from the normal to the quantum well planes, a related soliton-lattice state can occur which has kinks in the dependence of the relative phase between electrons in opposite layers on the coordinate perpendicular to the in-plane component of the magnetic field. In this article we evaluate the collective modes of this soliton-lattice state in the generalized random-phase aproximation. We find that, in addition to the Goldstone modes associated with the broken translational symmetry of the soliton-lattice state, higher energy collective modes occur which are closely related to the Goldstone modes present in the spontaneously phase-coherent state. We study the evolution of these collective modes as a function of the strength of the in-plane magnetic field and comment on the possibility of using the in-plane field to generate a finite wave probe of the spontaneously phase-coherent state.Comment: REVTEX, 37 pages (text) and 15 uuencoded postscript figure

Tycho 2 stars with infrared excess in the MSX Point Source Catalogue

Stars of all evolutionary phases have been found to have excess infrared emission due to the presence of circumstellar material. To identify such stars, we have positionally correlated the infrared MSX point source catalogue and the Tycho 2 optical catalogue. A near/mid infrared colour criteria has been developed to select infrared excess stars. The search yielded 1938 excess stars, over half (979) have never previously been detected by IRAS. The excess stars were found to be young objects such as Herbig Ae/Be and Be stars, and evolved objects such as OH/IR and carbon stars. A number of B type excess stars were also discovered whose infrared colours could not be readily explained by known catalogued objects.Comment: Added Comment: 16 pages, 9 figures, accepted for publication in MNRA