5,433 research outputs found
Quantum nature of the critical points of substances
Thermodynamics of chemical elements, based on the two-component
electron-nuclear plasma model shows that the critical parameters for the
liquid-vapor transition are the quantum values for which the classical limit is
absent.Comment: 4 pages, no figure
Evolution of the Dependence of Residual Lifetimes
We investigate the dependence properties of a vector of residual lifetimes by means of the copula associated with the conditional distribution function. In particular, the evolution of positive dependence properties (like quadrant dependence and total positivity) are analyzed and expressions for the evolution of measures of association are given
Initiation of a Stable Convective Hydroclimatic Regime in Central America Circa 9000 Years BP
Many Holocene hydroclimate records show rainfall changes that vary with local orbital insolation. However, some tropical regions display rainfall evolution that differs from gradual precessional pacing, suggesting that direct rainfall forcing effects were predominantly driven by sea-surface temperature thresholds or inter-ocean temperature gradients. Here we present a 12,000 yr continuous U/Th-dated precipitation record from a Guatemalan speleothem showing that Central American rainfall increased within a 2000 yr period from a persistently dry state to an active convective regime at 9000 yr BP and has remained strong thereafter. Our data suggest that the Holocene evolution of Central American rainfall was driven by exceeding a temperature threshold in the nearby tropical oceans. The sensitivity of this region to slow changes in radiative forcing is thus strongly mediated by internal dynamics acting on much faster time scales
Habitat Characteristics Associated with the Distribution and Abundance of \u3cem\u3eHistrionicus histrionicus\u3c/em\u3e (Harlequin Ducks) Wintering in Southern New England
Histrionicus histrionicus (Harlequin Ducks) that winter along the east coast of North America are listed as a population of special concern in Canada, and they use several coastal wintering sites in southern New England that are subject to varying degrees of urbanization. We studied patterns of habitat use by Harlequin Ducks at 12 known wintering sites in southern New England. An average of 327 ± 114 Harlequin Ducks were found at the sites during the winters of 2001–2003. More Harlequin Ducks wintered at sites south of Cape Cod, MA that had greater mollusk (709,133 ± 504,568 versus 97,154 ± 72,427 kcal ha−1) and crustacean (27,907 ± 16,312 versus 1412 ± 1675 kcal ha−1) prey energy density, and a higher index of hunting activity (2.4 ± 1.2 versus 1.4 ± 0.5) than sites to the north. We used logistic regression analysis at 12 sites inhabited by Harlequin Ducks and 12 nearby sites of similar geomorphology that did not support Harlequin Ducks to identify habitat characteristics that best explained their distribution in southern New England. Our analysis identified two habitat characteristics that affected the likelihood a site was used by Harlequin Ducks: 1) the proportion of residential, commercial, and industrial land use within a 100-m radius of the perimeter of the site; and 2) distance to the nearest Harlequin Duck wintering site. However, other factors, including those related to their extremely low population size, need to also be considered as recommendations are developed for the conservation of east coast Harlequin Ducks
Influence of Topological Edge States on the Properties of Al/Bi2Se3/Al Hybrid Josephson Devices
In superconductor-topological insulator-superconductor hybrid junctions, the
barrier edge states are expected to be protected against backscattering, to
generate unconventional proximity effects, and, possibly, to signal the
presence of Majorana fermions. The standards of proximity modes for these types
of structures have to be settled for a neat identification of possible new
entities. Through a systematic and complete set of measurements of the
Josephson properties we find evidence of ballistic transport in coplanar
Al-Bi2Se3-Al junctions that we attribute to a coherent transport through the
topological edge state. The shunting effect of the bulk only influences the
normal transport. This behavior, which can be considered to some extent
universal, is fairly independent of the specific features of superconducting
electrodes. A comparative study of Shubnikov - de Haas oscillations and
Scanning Tunneling Spectroscopy gave an experimental signature compatible with
a two dimensional electron transport channel with a Dirac dispersion relation.
A reduction of the size of the Bi2Se3 flakes to the nanoscale is an unavoidable
step to drive Josephson junctions in the proper regime to detect possible
distinctive features of Majorana fermions.Comment: 11 pages, 14 figure
Using Mussel Isotope Ratios to Assess Anthropogenic Nitrogen Inputs to Freshwater Ecosystems
Stable nitrogen isotope ratios (δ15N) of freshwater mussels from a series of lakes and ponds were related to watershed land use characteristics to assess their utility in determining the source of nitrogen inputs to inland water bodies. Nitrogen isotope ratios measured in freshwater mussels from 19 lakes and ponds in Rhode Island, U.S.A., ranged from 4.9–12.6% and were found to significantly correlate with the fraction of residential development in 100 and 200 m buffer zones around the ponds. Mussel δ15N values in 12 of the 19 ponds also showed significant correlation with average dissolved nitrate concentrations, which ranged from 23–327 μg L-1. These observations, in light of previous studies which link elevated δ15N values of nitrogen derived from septic wastewater with those seen in biota, suggest that mussel isotope ratios may reflect nitrogen source in freshwater ecosystems. We followed an iterative approach using multiple regression analysis to assess the relationship between mussel δ15N and the land use categories fraction residential development, fraction feedlot agriculture, fraction row-crop agriculture, and fraction natural vegetation in 100 and 200 m buffer zones and pond watersheds. From this we developed a simple regression model to predict mussel δ15N from the fraction of residential development in the 200 m buffer zone around the pond. Subsequent testing with data from 16 additional sites in the same ecoregion led us to refine the model by incorporating the fraction of natural vegetation. The overall average absolute difference between measured and predicted δ15N values using the two-parameter model was 1.6%. Potential sources of error in the model include differences in the scale and categorization of land-use data used to generate and test the model, differences in physical characteristics, such as retention time and range of residential development, and exclusion of sources of enriched nitrogen such as runoff from feedlot operations or increased nitrogen loading from inefficient or failed septic systems
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation
International audienceVoltage-gated Na(+) (NaV) channels are key regulators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical determinant of arrhythmias in heart failure. However, the global native phosphorylation pattern of NaV1.5 subunits associated with these arrhythmogenic disorders and the associated channel regulatory defects remain unknown. Here, we undertook phosphoproteomic analyses to identify and quantify in situ the phosphorylation sites in the NaV1.5 proteins purified from adult WT and failing CaMKIIδc-overexpressing (CaMKIIδc-Tg) mouse ventricles. Of 19 native NaV1.5 phosphorylation sites identified, two C-terminal phosphoserines at positions 1938 and 1989 showed increased phosphorylation in the CaMKIIδc-Tg compared with the WT ventricles. We then tested the hypothesis that phosphorylation at these two sites impairs fibroblast growth factor 13 (FGF13)-dependent regulation of NaV1.5 channel inactivation. Whole-cell voltage-clamp analyses in HEK293 cells demonstrated that FGF13 increases NaV1.5 channel availability and decreases late Na(+) current, two effects that were abrogated with NaV1.5 mutants mimicking phosphorylation at both sites. Additional co-immunoprecipitation experiments revealed that FGF13 potentiates the binding of calmodulin to NaV1.5 and that phosphomimetic mutations at both sites decrease the interaction of FGF13 and, consequently, of calmodulin with NaV1.5. Together, we have identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIδc-dependent arrhythmogenic disorders in failing hearts
On Conformal Field Theory and Stochastic Loewner Evolution
We describe Stochastic Loewner Evolution on arbitrary Riemann surfaces with
boundary using Conformal Field Theory methods. We propose in particular a CFT
construction for a probability measure on (clouded) paths, and check it against
known restriction properties. The probability measure can be thought of as a
section of the determinant bundle over moduli spaces of Riemann surfaces.
Loewner evolutions have a natural description in terms of random walk in the
moduli space, and the stochastic diffusion equation translates to the Virasoro
action of a certain weight-two operator on a uniformised version of the
determinant bundle.Comment: 24 pages, 4 figures, LaTeX; v2: added section 4.1, references and
minor clarifications, version to appear in NP
- …