1,681 research outputs found

    Combined Description of NN\bf{\overline{N}N} Scattering and Annihilation With A Hadronic Model

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    A model for the nucleon-antinucleon interaction is presented which is based on meson-baryon dynamics. The elastic part is the GG-parity transform of the Bonn NNNN potential. Annihilation into two mesons is described in terms of microscopic baryon-exchange processes including all possible combinations of π,η,ρ,ω,a0,f0,a1,f1,a2,f2,K,K\pi,\eta,\rho,\omega,a_0,f_0,a_1,f_1,a_2,f_2,K,K^*. The remaining annihilation part is taken into account by a phenomenological energy- and state independent optical potential of Gaussian form. The model enables a simultaneous description of nucleon-antinucleon scattering and annihilation phenomena with fair quality.Comment: revised version, REVTEX, 9 pages, 10 figures available from this URL ftp://ikp113.ikp.kfa-juelich.de/pub/kph140/nucl-th.9411014.u

    Pearl-chain waveguides machined with a femtosecond high-energy oscillator

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    A new regime of waveguides consisting of aligned spheres of strongly changed refractive - index in fused silica are explored and their guiding properties are measured

    Housing situation and healthcare for patients in a psychiatric centre in Berlin, Germany: a cross-sectional patient survey

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    OBJECTIVE: To determine the housing situation among people seeking psychiatric treatment in relation to morbidity and service utilisation. DESIGN: Cross-sectional patient survey. SETTING: Psychiatric centre with a defined catchment area in Berlin, Germany, March-September 2016. PARTICIPANTS: 540 psychiatric inpatients including day clinics (43.2% of all admitted patients in the study period (n=1251)). MAIN OUTCOME MEASURES: Housing status 30 days prior the interview as well as influencing variables including service use, psychiatric morbidity and sociodemographic variables. RESULTS: In our survey, 327 participants (68.7%) currently rented or owned an own apartment; 62 (13.0%) reported to be homeless (living on the street or in shelters for homeless or refugees); 87 (18.3%) were accommodated in sociotherapeutic facilities. Participants without an own apartment were more likely to be male and younger and to have a lower level of education. Homeless participants were diagnosed with a substance use disorder significantly more often (74.2%). Psychotic disorders were the highest among homeless participants (29.0%). Concerning service use, we did neither find a lower utilisation of ambulatory services nor a higher utilisation of hospital-based care among homeless participants. CONCLUSIONS: Our findings underline the need for effective housing for people with mental illness. Despite many sociotherapeutic facilities, a concerning number of people with mental illness is living in homelessness. Especially early interventions addressing substance use might prevent future homelessness

    Die Dankeskirche in Berlin und deren feierliche Einweihung am 3. Januar 1884

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    DIE DANKESKIRCHE IN BERLIN UND DEREN FEIERLICHE EINWEIHUNG AM 3. JANUAR 1884 Die Dankeskirche in Berlin und deren feierliche Einweihung am 3. Januar 1884 / Brückner, ... (Public Domain) ( - ) ColorChart ( - ) Cover front ( - ) Endsheet ( - ) Illustration: Die Dankeskirche in Berlin auf dem Weddingplatz ( - ) Title page ( - ) Einweihungsfeier der Dankeskirche in Berlin (3) Weiheact (4) Liturgie (8) Fest-Predigt (8) Schluß-Liturgie (12) Gebet, Vaterunser, Segen (13) Die Dankeskirche auf dem Weddingplatz in Berlin (14) Illustration: Die Dankeskirche in Berlin auf dem Weddingplatz (Situationsplan) (14) Illustration: Die Dankeskirche in Berlin auf dem Weddingplatz (Grundriß) (15) Illustration: Die Dankeskirche in Berlin auf dem Weddingplatz (Durchschnitts-Ansicht) ([16]) Nachsatzblatt ( - ) Cover back ( -

    Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites.

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    Our work on targeting redox equilibria of malarial parasites propagating in red blood cells has led to the selection of six 1,4-naphthoquinones, which are active at nanomolar concentrations against the human pathogen Plasmodium falciparum in culture and against Plasmodium berghei in infected mice. With respect to safety, the compounds do not trigger hemolysis or other signs of toxicity in mice. Concerning the antimalarial mode of action, we propose that the lead benzyl naphthoquinones are initially oxidized at the benzylic chain to benzoyl naphthoquinones in a heme-catalyzed reaction within the digestive acidic vesicles of the parasite. The major putative benzoyl metabolites were then found to function as redox cyclers: (i) in their oxidized form, the benzoyl metabolites are reduced by NADPH in glutathione reductase-catalyzed reactions within the cytosols of infected red blood cells; (ii) in their reduced forms, these benzoyl metabolites can convert methemoglobin, the major nutrient of the parasite, to indigestible hemoglobin. Studies on a fluorinated suicide-substrate indicate as well that the glutathione reductase-catalyzed bioactivation of naphthoquinones is essential for the observed antimalarial activity. In conclusion, the antimalarial naphthoquinones are suggested to perturb the major redox equilibria of the targeted infected red blood cells, which might be removed by macrophages. This results in development arrest and death of the malaria parasite at the trophozoite stage
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