Space Charge Neutralization and its Dynamic Effects

Electronic Conference Proceedings (eConf) - Proceedings sur le site http://hb2006.kek.jp/International audienceHigh-power accelerators are being studied for several projects including accelerator driven neutron or neutrino sources. The low energy part of these facilities has to be carefully optimized to match the beam requirements of the higher energy parts. In this low energy part, the space charge self force, induced by a high intensity beam, has to be carefully controlled. This nonlinear force can generate a large and irreversible emittance growth of the beam. To reduce the space charge (SC), neutralization of the beam charge can be done by capturing some particles of the ionised residual gas in the vacuum chamber. This space charge compensation (SCC) regime complicates the beam dynamics study. This contribution aims to modelize the beam behavior in such a regime and to give order of magnitude to the linac designer for the neutralization rise time and the induced emittance growth

AI-based analysis of super-resolution microscopy: Biological discovery in the absence of ground truth

The nanoscale resolution of super-resolution microscopy has now enabled the use of fluorescent based molecular localization tools to study whole cell structural biology. Machine learning based analysis of super-resolution data offers tremendous potential for discovery of new biology, that by definition is not known and lacks ground truth. Herein, we describe the application of weakly supervised learning paradigms to super-resolution microscopy and its potential to enable the accelerated exploration of the molecular architecture of subcellular macromolecules and organelles.Comment: 14 pages, 3 figure

Temporal Dynamics and Impact of Climate Factors on the Incidence of Zoonotic Cutaneous Leishmaniasis in Central Tunisia

Old world cutaneous leishmaniasis is a vector-borne disease occurring in rural areas of developing countries. The main reservoirs are the rodents Psammomys obesus and Meriones shawi. Zoonotic Leishmania transmission cycle is maintained in the burrows of rodents where the sand fly Phlebotomus papatasi finds the ideal environment and source of blood meals. In the present study we showed seasonality of the incidence of disease during the same cycle with an inter-epidemic period ranging from 4 to 7 years. We evaluated the impact of climate variables (rainfall, humidity and temperature) on the incidence of zoonotic cutaneous leishmaniais in central Tunisia. We confirmed that the risk of disease is mainly influenced by the humidity related to the months of July to September during the same season and mean rainfall lagged by 12 to 14 months

Le Numidien de la Tunisie septentrionale: données stratigraphiques et interprétation géodynamique

The Numidian flysch consists of a thick turbiditic sandy and clayey formation of Oligocene-Lower Miocene age which outcrops largely in northern Tunisia. Concerning the relationship between the Numidian formation and its «substratum», two hypothesis are discussed : i) allochtonous Numidian units (tangential abnormal contact) ; ii) autochtonous Numidian units (sedimentary contact : locally downlap). Detailed investigation undertaken in the study area, based on the survey and the dating of lithological logs, coupled with geodynamic and petrogenetic events, lead to the following results : i) absence of tangential tectonic contact in the base of Numidian series ; ii) a significant Tertiary tectonics attested by several phases. Moreover, the Numidian siliciclastic series are affected, like the other Tertiary formations in the North of Tunisia, by south-east ward deep-seated thrusts, oriented N50-60.El flysch Numidiense es una formación arenisco-arcillosa de gran espesor y de edad Oligoceno-Mioceno inferior, que aflora en el norte de Túnez. La naturaleza del contacto basal de esta formación ha suscitado numerosas discusiones. De ellas destacan dos hipótesis: 1) las unidades numidienses alóctonas se apoyan en forma de contacto anormal tangencial, y 2) se trata de unidades autóctonas (contacto sedimentario normal, a veces de tipo "downlap").El levantamiento de cortes litológicos detallados y su datación, combinado con datos de tipo geodinámico y petrogenético, ha permitido confirmar la ausencia de un contacto tectónico tangencial en la base del Numidiense y por el contrario, establecer la existencia de una significativa tectónica terciaria desarrollada en varias fases. Asi, las series siliciclásticas Numidienses se ven afectadas, como otras formaciones terciarias del norte de Túnez, por cabalgamientos de vergencia SE

A survey of three-dimensional turbo codes and recent performance enhancements

This paper presents a survey of two techniques intended for improving the performance of conventional turbo codes (TCs). The first part of this work is dedicated to explore a hybrid concatenation structure combining both parallel and serial concatenation based on a three-dimensional (3D) code. The 3D structure, recently introduced by Berrou et al., is able to ensure large asymptotic gains at very low error rates at the expense of an increase in complexity and a loss in the convergence threshold. In order to reduce the loss in the convergence threshold, the authors consider first a time-varying construction of the post-encoded parity. Then, they investigate the association of the 3D TC with high-order modulations according to the bit-interleaved coded modulation approach. The second part of this study deals with irregular TCs. In contrast to 3D TCs, although irregular TCs can achieve performance closer to capacity, their asymptotic performance is very poor. Therefore, the authors propose irregular turbo coding schemes with suitable interleavers in order to improve their distance properties. Finally, a modified encoding procedure, inspired from the 3D TC, makes it possible to obtain irregular TCs which perform better than the corresponding regular codes in both the waterfall and the error floor regions

Is Adherence to Imatinib Mesylate Treatment Among Patients with Chronic Myeloid Leukemia Associated with Better Clinical Outcomes in Qatar?

Background: Despite the revolutionary success of introducing tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), for treating chronic myeloid leukemia (CML), a substantial proportion of patients' treatments fail. Aim: This study investigates the correlation between patient adherence and failure of TKIs' treatment in a follow-up study. Methods: This is a follow-up study of a new cohort of CML patients. Adherence to IM is assessed using the Medication Event Monitoring System (MEMS 6 TrackCap, AARDEX Ltd). The 9-item Morisky Medication Adherence Scale, medication possession ratio (MPR) calculation, and the electronic medical records are used for identifying potential factors that influence adherence. Clinical outcomes are assessed according to the European LeukemiaNet 2013 guidelines via reverse transcriptase quantitative polymerase chain reaction measurement of the level of BCR-ABL1 transcripts in peripheral blood. Response is classified at the hematological, cytogenetic, and molecular levels into optimal, suboptimal, or failure. Results: A total of 36 CML patients (5 citizens and 31 noncitizen residents) consented to participate in the study. The overall mean MEMS score was 89. Of the 36 patients, 22 (61%) were classified as adherent (mean: 95) and 14 (39%) were classified as nonadherent (mean: 80.2). Adherent patients were significantly more likely to obtain optimal response (95%) compared to the nonadherent group (14.3%; P < 0.0001). The rate of poor adherence was as high as 39% using MEMS, which correlates with 37% treatment failure rate. The survey results show that 97% of patients increased the IM dose by themselves when they felt unwell and 31% of them took the missing IM dose when they remembered. Other factors known to influence adherence show that half of patients developed one or more side effects, 65% of patients experienced lack of funds, 13% of patients declared unavailability of the drug in the NCCCR pharmacy, and 72% of patients believed that IM would cure the disease. The MPR results reveal that 16% of patients had poor access to treatment through the hospital pharmacy. Discussion and conclusion: This is the first prospective study to evaluate CML patients' adherence and response to IM in Qatar. The high rate of treatment failure observed in Qatar is explained by poor adherence. An economic factor (unaffordable drug prices) is one of the main causes of nonadherence and efforts should be made locally to improve access to medication for cancer diseases. Other risk factors associated with poor adherence could be improved by close monitoring and dose adjustment. Monitoring risk factors for poor adherence and patient education that include direct communication between the health-care teams, doctors, nurses, pharmacists, and patients are essential components for maximizing the benefits of TKI therapy and could rectify this problem. The preliminary results show that patients' response to treatment may be directly linked to patients' adherence to treatment. However, further in-depth and specific analysis may be necessary in a larger cohort

Contextualising the pervasive impact of macroeconomic austerity on prison health in England: A qualitative study among international policymakers

Background: Prisons offer the state the opportunity to gain access to a population that is at particularly high risk of ill-health. Despite the supportive legal and policy structures surrounding prison rehabilitation, the oppressive nature of the austerity policy in England threatens its advanced improvement.Methods: Using grounded theory methodology, this is the first interdisciplinary qualitative study to explore the impact of macroeconomic austerity on prison health in England from the perspective of 29 international prison policymakers.Results: The far-reaching impact of austerity in England has established a regressive political system that shapes the societal attitude towards social issues, which has exacerbated the existing poor health of the prisoners. Austerity has undermined the notion of social collectivism, imposed a culture of acceptance among prison bureaucrats and the wider community, and normalised the devastating impacts of prison instability. These developments are evidenced by the increasing levels of suicide, violence, radicalisation and prison gangs among prisoners, as well as the imposition of long working hours and the high levels of absenteeism among prison staff.Conclusions: This study underscores an important and yet unarticulated phenomenon that despite being the fifth largest economy in the world, England’s poorest, marginalised and excluded population continues to bear the brunt of austerity. Reducing the prison population, using international obligations as minimum standards to protect prisoners’ right to health and providing greater resources would create a more positive and inclusive system, in line with England’s international and domestic commitments to the humane treatment of all people

Financial time series prediction using spiking neural networks

In this paper a novel application of a particular type of spiking neural network, a Polychronous Spiking Network, was used for financial time series prediction. It is argued that the inherent temporal capabilities of this type of network are suited to non-stationary data such as this. The performance of the spiking neural network was benchmarked against three systems: two "traditional", rate-encoded, neural networks; a Multi-Layer Perceptron neural network and a Dynamic Ridge Polynomial neural network, and a standard Linear Predictor Coefficients model. For this comparison three non-stationary and noisy time series were used: IBM stock data; US/Euro exchange rate data, and the price of Brent crude oil. The experiments demonstrated favourable prediction results for the Spiking Neural Network in terms of Annualised Return and prediction error for 5-Step ahead predictions. These results were also supported by other relevant metrics such as Maximum Drawdown and Signal-To-Noise ratio. This work demonstrated the applicability of the Polychronous Spiking Network to financial data forecasting and this in turn indicates the potential of using such networks over traditional systems in difficult to manage non-stationary environments. © 2014 Reid et al

Increased Neural Activity of a Mushroom Body Neuron Subtype in the Brains of Forager Honeybees

Honeybees organize a sophisticated society, and the workers transmit information about the location of food sources using a symbolic dance, known as ‘dance communication’. Recent studies indicate that workers integrate sensory information during foraging flight for dance communication. The neural mechanisms that account for this remarkable ability are, however, unknown. In the present study, we established a novel method to visualize neural activity in the honeybee brain using a novel immediate early gene, kakusei, as a marker of neural activity. The kakusei transcript was localized in the nuclei of brain neurons and did not encode an open reading frame, suggesting that it functions as a non-coding nuclear RNA. Using this method, we show that neural activity of a mushroom body neuron subtype, the small-type Kenyon cells, is prominently increased in the brains of dancer and forager honeybees. In contrast, the neural activity of the two mushroom body neuron subtypes, the small-and large-type Kenyon cells, is increased in the brains of re-orienting workers, which memorize their hive location during re-orienting flights. These findings demonstrate that the small-type Kenyon cell-preferential activity is associated with foraging behavior, suggesting its involvement in information integration during foraging flight, which is an essential basis for dance communication