ABIOTIC DEGRADATION OF IODOSULFURON-METHYL-ESTER IN AQUEOUS SOLUTION

The abiotic degradation of iodosulfuron-methyl-ester was investigated under both alkaline and acidic pH conditions in the dark, and results showed it to be a rather stable molecule in neutral or slightly alkaline environments. Photochemical reactions were studied using a high-pressure mercury arc lamp, and results showed that direct phototransformation is possible under normal environmental conditions (ì > 290 nm). High-performance liquid chromatography (HPLC-UV and HPLC-MS) analyses were used to identify the degradates and to study the kinetics of photodecomposition and hydrolysis. Five main products of iodosulfuron-methyl-ester degradation were tentatively identified, and one of them (4-methoxy-6-methyl-1,3,5-triazin-2-amine) was confirmed using an authentic standard. Among the phototransformation mechanisms, photosubstitution of the iodide atom by a hydroxyl group, photodissociation of the N-S bond, and photoassisted hydrolysis were observed. The quantum efficiencies (multiwavelength quantum yield) of the photodegradation under different conditions were determined, and values of 0.054 ( 0.02 (pH 9.6), 0.08 ( 0.02 (pH 7), and 0.044 ( 0.008 (pH 5.3) were obtained

Photon detection with CMOS sensors for fast imaging

International audiencePixel detectors employed in high energy physics aim to detect single minimum ionizing particle with micrometric positioning resolution. Monolithic CMOS sensors succeed in this task thanks to a low equivalent noise charge per pixel of around 10 to 15 e-, and a pixel pitch varying from 10 to a few 10 s of microns. Additionally, due to the possibility for integration of some data treatment in the sensor itself, readout times of have been reached for 100 kilo-pixels sensors. These aspects of CMOS sensors are attractive for applications in photon imaging. For X-rays of a few keV, the efficiency is limited to a few % due to the thin sensitive volume. For visible photons, the back-thinned version of CMOS sensor is sensitive to low intensity sources, of a few hundred photons. When a back-thinned CMOS sensor is combined with a photo-cathode, a new hybrid detector results (EBCMOS) and operates as a fast single photon imager. The first EBCMOS was produced in 2007 and demonstrated single photon counting with low dark current capability in laboratory conditions. It has been compared, in two different biological laboratories, with existing CCD-based 2D cameras for fluorescence microscopy. The current EBCMOS sensitivity and frame rate is comparable to existing EMCCDs. On-going developments aim at increasing this frame rate by, at least, an order of magnitude. We report in conclusion, the first test of a new CMOS sensor, LUCY, which reaches 1000 frames per seco

Performance of the reconstruction algorithms of the FIRST experiment pixel sensors vertex detector

Hadrontherapy treatments use charged particles (e.g. protons and carbon ions) to treat tumors. During a therapeutic treatment with carbon ions, the beam undergoes nuclear fragmentation processes giving rise to significant yields of secondary charged particles. An accurate prediction of these production rates is necessary to estimate precisely the dose deposited into the tumours and the surrounding healthy tissues. Nowadays, a limited set of double differential carbon fragmentation cross-section is available. Experimental data are necessary to benchmark Monte Carlo simulations for their use in hadrontherapy. The purpose of the FIRST experiment is to study nuclear fragmentation processes of ions with kinetic energy in the range from 100 to 1000 MeV/u. Tracks are reconstructed using information from a pixel silicon detector based on the CMOS technology. The performances achieved using this device for hadrontherapy purpose are discussed. For each reconstruction step (clustering, tracking and vertexing), different methods are implemented. The algorithm performances and the accuracy on reconstructed observables are evaluated on the basis of simulated and experimental data

Performance study of a MegaPixel single photon position sensitive photodetector EBCMOS

International audienceThis development is related to the design and the integration of a Monolithic Active Pixel Sensor (MAPS) into a photosensitive proximity focusing vacuum-based tube. This EBCMOS project is dedicated to the fluorescent and the bioluminescent high speed imaging. The results of the full characterization of the first prototype are presented. Comparative tests with different fluorescent dyes have been performed in biology laboratories. Preliminary conclusions on the ability of EBCMOS to perform fast single-molecule tracking will be given

Development of ultra-light pixelated ladders for an ILC vertex detector

The development of ultra-light pixelated ladders is motivated by the requirements of the ILD vertex detector at ILC. This paper summarizes three projects related to system integration. The PLUME project tackles the issue of assembling double-sided ladders. The SERWIETE project deals with a more innovative concept and consists in making single-sided unsupported ladders embedded in an extra thin plastic enveloppe. AIDA, the last project, aims at building a framework reproducing the experimental running conditions where sets of ladders could be tested

First results from the Development of a New Generation of Hybrid Photon Detectors: EBCMOS

International audienceThe proximity focusing Hybrid Photon Detector (HPD) concept is implemented to develop a single photon sensitive Electron Bombarded CMOS (EBCMOS). The first demonstrator has been produced by the collaboration between the EBCMOS group of IPNL, the CMOS sensor group of IPHC and the R&D department of PHOTONIS. The prototype characteristics (dark current, gain, spatial and energy resolutions) are presented. The futur developments of this type of photo detector are discussed

States on pseudo effect algebras and integrals

We show that every state on an interval pseudo effect algebra $E$ satisfying some kind of the Riesz Decomposition Properties (RDP) is an integral through a regular Borel probability measure defined on the Borel $\sigma$-algebra of a Choquet simplex $K$. In particular, if $E$ satisfies the strongest type of (RDP), the representing Borel probability measure can be uniquely chosen to have its support in the set of the extreme points of $K.

Typhoid fever outbreak in the Democratic Republic of Congo: Case control and ecological study

During 2011 a large outbreak of typhoid fever affected an estimated 1430 people in Kikwit, Democratic Republic of Congo. The outbreak started in military camps in the city but then spread to the general population. This paper reports the results of an ecological analysis and a case-control study undertaken to examine water and other possible transmission pathways. Attack rates were determined for health areas and risk ratios were estimated with respect to spatial exposures. Approximately 15 months after the outbreak, demographic, environmental and exposure data were collected for 320 cases and 640 controls residing in the worst affected areas, using a structured interview questionnaire. Unadjusted and adjusted odds ratios were estimated. Complete data were available for 956 respondents. Residents of areas with water supplied via gravity on the mains network were at much greater risk of disease acquisition (risk ratio = 6.20, 95%CI 3.39-11.35) than residents of areas not supplied by this mains network. In the case control study, typhoid was found to be associated with ever using tap water from the municipal supply (OR = 4.29, 95% CI 2.20-8.38). Visible urine or faeces in the latrine was also associated with increased risk of typhoid and having chosen a water source because it is protected was negatively associated. Knowledge that washing hands can prevent typhoid fever, and stated habit of handwashing habits before cooking or after toileting was associated with increased risk of disease. However, observed associations between handwashing or plate-sharing with disease risk could very likely be due to recall bias. This outbreak of typhoid fever was strongly associated with drinking water from the municipal drinking water supply, based on the descriptive and analytic epidemiology and the finding of high levels of faecal contamination of drinking water. Future outbreaks of potentially waterborne disease need an integrated response that includes epidemiology and environmental microbiology during early stages of the outbreak

Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009

BACKGROUND: In highly populated African urban areas where access to clean water is a challenge, water source contamination is one of the most cited risk factors in a cholera epidemic. During the rainy season, where there is either no sewage disposal or working sewer system, runoff of rains follows the slopes and gets into the lower parts of towns where shallow wells could easily become contaminated by excretes. In cholera endemic areas, spatial information about topographical elevation could help to guide preventive interventions. This study aims to analyze the association between topographic elevation and the distribution of cholera cases in Harare during the cholera epidemic in 2008 and 2009. METHODS: We developed an ecological study using secondary data. First, we described attack rates by suburb and then calculated rate ratios using whole Harare as reference. We illustrated the average elevation and cholera cases by suburbs using geographical information. Finally, we estimated a generalized linear mixed model (under the assumption of a Poisson distribution) with an Empirical Bayesian approach to model the relation between the risk of cholera and the elevation in meters in Harare. We used a random intercept to allow for spatial correlation of neighboring suburbs. RESULTS: This study identifies a spatial pattern of the distribution of cholera cases in the Harare epidemic, characterized by a lower cholera risk in the highest elevation suburbs of Harare. The generalized linear mixed model showed that for each 100 meters of increase in the topographical elevation, the cholera risk was 30% lower with a rate ratio of 0.70 (95% confidence interval=0.66-0.76). Sensitivity analysis confirmed the risk reduction with an overall estimate of the rate ratio between 20% and 40%. CONCLUSION: This study highlights the importance of considering topographical elevation as a geographical and environmental risk factor in order to plan cholera preventive activities linked with water and sanitation in endemic areas. Furthermore, elevation information, among other risk factors, could help to spatially orientate cholera control interventions during an epidemic

Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality control

International audienceMonitoring of the dose deposition during carbon ion therapy is a crucial issue for the quality control of such treatments. Recent studies have demonstrated that an ion-range control with millimeter resolution is feasible on a pencil-beam basis in homogeneous targets with prompt gamma detection for proton beams [1] and with Proton Interaction Vertex Imaging (PIVI) for carbon beams [2]. The present communication aims at describing our experimental and Monte Carlo simulation results. [1] J. Smeets et al., Phys. Med. Biol. 57 (2012) 3371-3405 [2] P. Henriquet et al., Phys. Med. Biol. 57 (2012) 4655-466