A Chandra X-ray detection of the L dwarf binary Kelu-1: Simultaneous Chandra and Very Large Array observations

Magnetic activity in ultracool dwarfs, as measured in X-rays and H$\alpha$, shows a steep decline after spectral type M7-M8. So far, no L dwarf has been detected in X-rays. In contrast, L dwarfs may have higher radio activity than M dwarfs. We observe L and T dwarfs simultaneously in X-rays and radio to determine their level of magnetic activity in the context of the general decline of magnetic activity with cooler effective temperatures. The field L dwarf binary Kelu-1 was observed simultaneously with Chandra and the Very Large Array. Kelu-1AB was detected in X-rays with $L_{\rm X} = 2.9_{-1.3}^{+1.8} \times 10^{25}$ erg/s, while it remained undetected in the radio down to a $3 \sigma$ limit of $L_{\rm R} \leq 1.4 \times 10^{13}$ erg/s/Hz. We argue that, whereas the X-ray and H$\alpha$ emissions decline in ultracool dwarfs with decreasing effective temperature, the radio luminosity stays (more or less) constant across M and early-L dwarfs. The radio surface flux or the luminosity may better trace magnetic activity in ultracool dwarfs than the ratio of the luminosity to the bolometric luminosity. Deeper radio observations (and at short frequencies) are required to determine if and when the cut-off in radio activity occurs in L and T dwarfs, and what kind of emission mechanism takes place in ultracool dwarfs.Comment: Accepted for publication as a Letter in Astronomy & Astrophysic

325 MHz VLA Observations of Ultracool Dwarfs TVLM 513-46546 and 2MASS J0036+1821104

We present 325 MHz (90 cm wavelength) radio observations of ultracool dwarfs TVLM 513-46546 and 2MASS J0036+1821104 using the Very Large Array (VLA) in June 2007. Ultracool dwarfs are expected to be undetectable at radio frequencies, yet observations at 8.5 GHz (3.5 cm) and 4.9 GHz (6 cm) of have revealed sources with > 100 {\mu}Jy quiescent radio flux and > 1 mJy pulses coincident with stellar rotation. The anomalous emission is likely a combination of gyrosynchrotron and cyclotron maser processes in a long-duration, large-scale magnetic field. Since the characteristic frequency for each process scales directly with the magnetic field magnitude, emission at lower frequencies may be detectable from regions with weaker field strength. We detect no significant radio emission at 325 MHz from TVLM 513-46546 or 2MASS J0036+1821104 over multiple stellar rotations, establishing 2.5{\sigma} total flux limits of 795 {\mu}Jy and 942 {\mu}Jy respectively. Analysis of an archival VLA 1.4 GHz observation of 2MASS J0036+1821104 from January 2005 also yields a non-detection at the level of < 130 {\mu}Jy . The combined radio observation history (0.3 GHz to 8.5 GHz) for these sources suggests a continuum emission spectrum for ultracool dwarfs which is either flat or inverted below 2-3 GHz. Further, if the cyclotron maser instability is responsible for the pulsed radio emission observed on some ultracool dwarfs, our low-frequency non-detections suggest that the active region responsible for the high-frequency bursts is confined within 2 stellar radii and driven by electron beams with energies less than 5 keV.Comment: 11 pages, 5 figures, submitted to A

Discovery of Radio Emission from the Tight M8 Binary: LP 349-25

We present radio observations of 8 ultracool dwarfs with a narrow spectral type range (M8-M9.5) using the Very Large Array at 8.5 GHz. Only the tight M8 binary LP 349-25 was detected. LP 349-25 is the tenth ultracool dwarf system detected in radio and its trigonometric parallax pi = 67.6 mas, recently measured by Gatewood et al., makes it the furthest ultracool system detected by the Very Large Array to date, and the most radio-luminous outside of obvious flaring activity or variability. With a separation of only 1.8 AU, masses of the components of LP 349-25 can be measured precisely without any theoretical assumptions (Forveille et al.), allowing us to clarify their fully-convective status and hence the kind of magnetic dynamo in these components which may play an important role to explain our detection of radio emission from these objects. This also makes LP 349-25 an excellent target for further studies with better constraints on the correlations between X-ray, radio emission and stellar parameters such as mass, age, temperature, and luminosity in ultracool dwarfs.Comment: accepted by ApJ, referee's comments included, typo in equation 1 correcte

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2alpha Does Not Block Abeta-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer's Disease

beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) initiates the production of beta-amyloid (Abeta), the major constituent of amyloid plaques in Alzheimer's disease (AD). BACE1 is elevated approximately 2-3 fold in AD brain and is concentrated in dystrophic neurites near plaques, suggesting BACE1 elevation is Abeta-dependent. Previously, we showed that phosphorylation of the translation initiation factor eIF2alpha de-represses translation of BACE1 mRNA following stress such as energy deprivation. We hypothesized that stress induced by Abeta might increase BACE1 levels by the same translational mechanism involving eIF2alpha phosphorylation. To test this hypothesis, we used three different genetic strategies to determine the effects of reducing eIF2alpha phosphorylation on Abeta-dependent BACE1 elevation in vitro and in vivo: 1) a two-vector adeno-associated virus (AAV) system to express constitutively active GADD34, the regulatory subunit of PP1c eIF2alpha phosphatase; 2) a non-phosphorylatable eIF2alpha S51A knockin mutation; 3) a BACE1-YFP transgene lacking the BACE1 mRNA 5' untranslated region (UTR) required for eIF2alpha translational regulation. The first two strategies were used in primary neurons and 5XFAD transgenic mice, while the third strategy was employed only in 5XFAD mice. Despite very effective reduction of eIF2alpha phosphorylation in both primary neurons and 5XFAD brains, or elimination of eIF2alpha-mediated regulation of BACE1-YFP mRNA translation in 5XFAD brains, Abeta-dependent BACE1 elevation was not decreased. Additionally, robust inhibition of eIF2alpha phosphorylation did not block Abeta-dependent APP elevation in primary neurons, nor did it reduce amyloid pathology in 5XFAD mice. We conclude that amyloid-associated BACE1 elevation is not caused by translational de-repression via eIF2alpha phosphorylation, but instead appears to involve a post-translational mechanism. These definitive genetic results exclude a role for eIF2alpha phosphorylation in Abeta-dependent BACE1 and APP elevation. We suggest a vicious pathogenic cycle wherein Abeta42 toxicity induces peri-plaque BACE1 and APP accumulation in dystrophic neurites leading to exacerbated Abeta production and plaque progression

The Search for Signatures Of Transient Mass Loss in Active Stars

The habitability of an exoplanet depends on many factors. One such factor is the impact of stellar eruptive events on nearby exoplanets. Currently this is poorly constrained due to heavy reliance on solar scaling relationships and a lack of experimental evidence. Potential impacts of Coronal Mass Ejections (CMEs), which are a large eruption of magnetic field and plasma from a star, are space weather and atmospheric stripping. A method for observing CMEs as they travel though the stellar atmosphere is the type II radio burst, and the new LOw Frequency ARray (LOFAR) provides a means for detection. We report on 15 hours of observation of YZ Canis Minoris (YZ CMi), a nearby M dwarf flare star, taken in LOFAR's beam-formed observation mode for the purposes of measuring transient frequency-dependent low frequency radio emission. The observations utilized Low-Band Antenna (10-90 MHz) or High-Band Antenna (110-190 MHz) for five three-hour observation periods. In this data set, there were no confirmed type II events in this frequency range. We explore the range of parameter space for type II bursts constrained by our observations Assuming the rate of shocks is a lower limit to the rate at which CMEs occur, no detections in a total of 15 hours of observation places a limit of $\nu_{type II} < 0.0667$ shocks/hr $\leq \nu_{CME}$ for YZ CMi due to the stochastic nature of the events and limits of observational sensitivity. We propose a methodology to interpret jointly observed flares and CMEs which will provide greater constraints to CMEs and test the applicability of solar scaling relations

PEMANTAUAN POLA PANGAN HARAPAN (PPH) MASYARAKAT TINGKAT KECAMATAN DI KOTA MEDAN

Efforts to obtain energy consumption based on Expect Food Pattern Score for all people of Medan City must continue to be realized to produce a healthy, active, and productive society. The purpose of monitoring in Food Consumption Pattern in 2020 is to obtain data on the community's Expected Food Pattern Score in each sub-district in Medan City during the covid19 pandemic era. Monitoring was carried out from mid-September 2020 to mid-November 2020. Each sub-district was represented by 50 households as a respondent. Sample/respondents are based on probability sampling, then the population of all respondent from 21 sub-district in Medan City become 1050 respondents. Respondents must be healthy, follow health protocols, be able to read, write and understand Expect Food Pattern Score, to be committed to participating in all activities, bring their family card and writing utensils. The monitoring results showed that each respondent from all sub-districts, there were those who consumed more types of food in certain sub-district than recommended, but some were still not as recommended in other sub-district. After processing all the data for each district, it turns out that the Expect Food Pattern Score for Medan City in 2020 is 92.29 higher than 2019 = 92.00