Associations of Maternal Complaints to Levator Ani Muscle Trauma within 9 Months after Vaginal Birth: A Prospective Observational Cohort Study

Introduction: Pelvic floor trauma in the form of partial or complete avulsions of the levator ani muscle (LAM) affects 6-42% of women after vaginal birth and can cause tremendous long-term morbidity. Many studies assessed morphological pelvic floor trauma after childbirth but lacked to evaluate women's associated short-term complaints. A proper assessment of trauma and subjective complaints after birth could help to assess possible associations between them and their relevance to women's daily life. Therefore, we aimed to assess women's complaints within the first months after birth in association to their LAM trauma. Materials and methods: Between 3/2017 and 4/2019, we prospectively evaluated vaginal births of 212 primiparous women with singletons in vertex presentation ≥ 36 + 0 gestational weeks for levator ani muscle (LAM) trauma by translabial ultrasound, for pelvic organ prolapse by clinical examination, and for urogynecological complaints using questionnaires 1-4 days (P1), 6-10 weeks (P2), and 6-9 months (P3) after birth. The questionnaires were self-designed but oriented to and modified from validated questionnaires. Women's complaints were evaluated for P1-P3 according to their LAM trauma state. Results: At P1, 67% of women showed an intact LAM, whereas 14.6% presented a hematoma, 6.6% a partial avulsion (PAV), and 11.8% a complete avulsion (CAV). At P2, 75.9% showed an intact LAM, 9.9% a PAV, and 14.2% a CAV. At P3, 72.9% of women with a LAM trauma in P1 and/or P2 were assessed with 21.6% being intact and 39.2% having a PAV and CAV, respectively. Obstetrical and baseline characteristics differed slightly between the groups. When comparing the time before and during pregnancy with the time after childbirth, birth itself affected women's complaints in all LAM state groups, but the presence of a LAM trauma, especially a CAV, had more negative effects. Conclusions: Vaginal birth changes the anatomical structure of the maternal birth canal and genital tract, and it alters women's perceptions and body function. In our study, LAM trauma did not change these effects tremendously within the first months. Therefore, other maternal, fetal, and obstetrical factors need consideration for the explanation of maternal complaints, in addition to long-term effects of trauma and dysfunction of the LAM and other birth canal structures

Differential responses of amphibians and reptiles to land-use change in the biodiversity hotspot of north-eastern Madagascar

Large expanses of tropical rainforest have been converted into agricultural land- scapes cultivated by smallholder farmers. This is also the case in north-eastern Madagascar; a region that retains significant proportions of forest cover despite slash-and-burn shifting hill rice cultivation and vanilla agroforestry expansion. The region is also a global hotspot for herpetofauna diversity, but how amphibians and reptiles are affected by land-use change remains largely unknown. Using a space- for-time study design, we compared species diversity and community composition across seven prevalent land uses: unburned (old-growth forest, forest fragment, and forest-derived vanilla agroforest) and burned (fallow-derived vanilla agroforest, woody fallow, and herbaceous fallow) land-use types, and rice paddy. We con- ducted six comprehensive, time-standardized searches across at least 10 replicates per land-use type and applied genetic barcoding to confirm species identification. We documented an exceptional diversity of herpetofauna (119 species; 91% endemic). Observed plot-level amphibian species richness was significantly higher in old-growth forest than in all other land-use types. Plot-level reptile species rich- ness was significantly higher in unburned land-use types compared with burned land-use types. For both amphibians and reptiles, the less-disturbed land-use types showed more uneven communities and the species composition in old-growth for- est differed significantly from all other land-use types. Amphibians had higher for- est dependency (38% of species occurred exclusively in old-growth forest) than reptiles (26%). Our analyses thus revealed that the two groups respond differently to land-use change: we found less pronounced losses of reptile species richness especially in unburned agricultural habitats, suggesting that reptiles are less suscep- tible to land-use change than amphibians, possibly due to their ability to cope with hotter and drier microclimates. In conclusion, our findings emphasize existing con- servation opportunities – especially for reptiles – in extensive agricultural land- scapes while highlighting the precarious situation of amphibians in disappearing old-growth forest

Bethe ansatz for the Harper equation: Solution for a small commensurability parameter

The Harper equation describes an electron on a 2D lattice in magnetic field and a particle on a 1D lattice in a periodic potential, in general, incommensurate with the lattice potential. We find the distribution of the roots of Bethe ansatz equations associated with the Harper equation in the limit as alpha=1/Q tends to 0, where alpha is the commensurability parameter (Q is integer). Using the knowledge of this distribution we calculate the higher and lower boundaries of the spectrum of the Harper equation for small alpha. The result is in agreement with the semiclassical argument, which can be used for small alpha.Comment: 17 pages including 5 postscript figures, Latex, minor changes, to appear in Phys.Rev.

Formation of nanoscale ferromagnetic MnAs crystallites in low-temperature grown GaAs

3 páginas, 3 figuras, 1 tabla.We report the formation of nanosize ferromagnetic MnAs crystallites imbedded in low-temperature grown GaAs using Mn+ ion implantation and subsequent annealing. The structural and magnetic properties of the crystallites have been characterized by transmission electron microscopy, electron beam induced x-ray fluorescence, and superconducting quantum interference device magnetometry. After an optimized thermal annealing at 750 °C, MnAs crystallites of 50 nm in size are formed. These nanomagnets show room temperature ferromagnetism.This work has been supported by QUEST, an NSF Science and Technology center (Grant No. DMR91.20007). P.J.W. is a postdoctoral fellow of the Deutsche Forschungsgemeinschaft (DFG) J.M.G. is a postdoctoral fellow of the Spanish Ministry of Education and Science.Peer reviewe

Mammalian behavior and physiology converge to confirm sharper cochlear tuning in humans

Frequency analysis of sound by the cochlea is the most fundamental property of the auditory system. Despite its importance, the resolution of this frequency analysis in humans remains controversial. The controversy persists because the methods used to estimate tuning in humans are indirect and have not all been independently validated in other species. Some data suggest that human cochlear tuning is considerably sharper than that of laboratory animals, while others suggest little or no difference between species. We show here in a single species (ferret) that behavioral estimates of tuning bandwidths obtained using perceptual masking methods, and objective estimates obtained using otoacoustic emissions, both also employed in humans, agree closely with direct physiological measurements from single auditory-nerve fibers. Combined with human behavioral data, this outcome indicates that the frequency analysis performed by the human cochlea is of significantly higher resolution than found in common laboratory animals. This finding raises important questions about the evolutionary origins of human cochlear tuning, its role in the emergence of speech communication, and the mechanisms underlying our ability to separate and process natural sounds in complex acoustic environments

Bloch electron in a magnetic field and the Ising model

The spectral determinant det(H-\epsilon I) of the Azbel-Hofstadter Hamiltonian H is related to Onsager's partition function of the 2D Ising model for any value of magnetic flux \Phi=2\pi P/Q through an elementary cell, where P and Q are coprime integers. The band edges of H correspond to the critical temperature of the Ising model; the spectral determinant at these (and other points defined in a certain similar way) is independent of P. A connection of the mean of Lyapunov exponents to the asymptotic (large Q) bandwidth is indicated.Comment: 4 pages, 1 figure, REVTE

Overview of mathematical approaches used to model bacterial chemotaxis II: bacterial populations

We review the application of mathematical modeling to understanding the behavior of populations of chemotactic bacteria. The application of continuum mathematical models, in particular generalized Keller–Segel models, is discussed along with attempts to incorporate the microscale (individual) behavior on the macroscale, modeling the interaction between different species of bacteria, the interaction of bacteria with their environment, and methods used to obtain experimentally verified parameter values. We allude briefly to the role of modeling pattern formation in understanding collective behavior within bacterial populations. Various aspects of each model are discussed and areas for possible future research are postulated