Surgeon\u27s perspective on short bowel syndrome: Where are we?

Short bowel syndrome (SBS) is due to a massive loss of small bowel: the reduction of gut function is below the minimum necessary to maintain health (in adults) and growth (in children) so intravenous supplementation is required. Parenteral nutrition represents the milestone of treatment and surgical attempts should be limited only when the residual bowel is sufficient to increase absorption, reducing diarrhea and slowing the transit time of nutrients, water and electrolytes. The surgical techniques lengthen the bowel (tapering it) or reverse a segment of it: developed in children, nowadays are popular also among adults. The issue is mainly represented by the residual length of the small bowel where ileum has shown increased adaptive function than jejunum, but colon should be considered because of its importance in the digestive process. These concepts have been translated also in intestinal transplantation, where a colonic graft is nowadays widely used and the terminal ileum is the selected segment for a living-related donation. The whole replacement by a bowel or multivisceral transplant is still affected by poor long term outcome and must be reserved to a select population of SBS patients, affected by intestinal failure associated with irreversible complications of parenteral nutrition

Solution of Two-Body Bound State Problems with Confining Potentials

The homogeneous Lippmann-Schwinger integral equation is solved in momentum space by using confining potentials. Since the confining potentials are unbounded at large distances, they lead to a singularity at small momentum. In order to remove the singularity of the kernel of the integral equation, a regularized form of the potentials is used. As an application of the method, the mass spectra of heavy quarkonia, mesons consisting from heavy quark and antiquark $(\Upsilon(b\bar{b}), \psi(c\bar{c}))$, are calculated for linear and quadratic confining potentials. The results are in good agreement with configuration space and experimental results.Comment: 6 pages, 5 table

Characterizing dark interactions with the halo mass accretion history and structural properties

We study the halo mass accretion history (MAH) and its correlation with the internal structural properties in coupled dark energy cosmologies (cDE). To accurately predict all the non-linear effects caused by dark interactions, we use the COupled Dark Energy Cosmological Simulations (CoDECS). We measure the halo concentration at z=0 and the number of substructures above a mass resolution threshold for each halo. Tracing the halo merging history trees back in time, following the mass of the main halo, we develope a MAH model that accurately reproduces the halo growth in term of M_{200} in the {\Lambda}CDM Universe; we then compare the MAH in different cosmological scenarios. For cDE models with a weak constant coupling, our MAH model can reproduce the simulation results, within 10% of accuracy, by suitably rescaling the normalization of the linear matter power spectrum at z=0, {\sigma}_8. However, this is not the case for more complex scenarios, like the "bouncing" cDE model, for which the numerical analysis shows a rapid growth of haloes at high redshifts, that cannot be reproduced by simply rescaling the value of {\sigma}_8. Moreover, at fixed value of {\sigma}_8, cold dark matter (CDM) haloes in these cDE scenarios tend to be more concentrated and have a larger amount of substructures with respect to {\Lambda}CDM predictions. Finally, we present an accurate model that relates the halo concentration to the time at which it assembles half or 4% of its mass. Combining this with our MAH model, we show how halo concentrations change while varying only {\sigma}_8 in a {\Lambda}CDM Universe, at fixed halo mass.Comment: 18 pages, 14 figures, accepted for publication in MNRA

Mass and Concentration estimates from Weak and Strong Gravitational Lensing: a Systematic Study

We study how well halo properties of galaxy clusters, like mass and concentration, are recovered using lensing data. In order to generate a large sample of systems at different redshifts we use the code MOKA. We measure halo mass and concentration using weak lensing data alone (WL), fitting to an NFW profile the reduced tangential shear profile, or by combining weak and strong lensing data, by adding information about the size of the Einstein radius (WL+SL). For different redshifts, we measure the mass and the concentration biases and find that these are mainly caused by the random orientation of the halo ellipsoid with respect to the line-of-sight. Since our simulations account for the presence of a bright central galaxy, we perform mass and concentration measurements using a generalized NFW profile which allows for a free inner slope. This reduces both the mass and the concentration biases. We discuss how the mass function and the concentration mass relation change when using WL and WL+SL estimates. We investigate how selection effects impact the measured concentration-mass relation showing that strong lens clusters may have a concentration 20-30% higher than the average, at fixed mass, considering also the particular case of strong lensing selected samples of relaxed clusters. Finally, we notice that selecting a sample of relaxed galaxy clusters, as is done in some cluster surveys, explain the concentration-mass relation biases.Comment: (1) DIFA-UniBO, (2) INAF-OABo, (3) INFN-BO, (4) JPL-Pasadena 18 pages, 19 figures - accepted for publication by MNRAS, two figures added for comparison with SGAS-SDSS and LoCuSS cluster

Effective range from tetramer dissociation data for cesium atoms

The shifts in the four-body recombination peaks, due to an effective range correction to the zero-range model close to the unitary limit, are obtained and used to extract the corresponding effective range of a given atomic system. The approach is applied to an ultracold gas of cesium atoms close to broad Feshbach resonances, where deviations of experimental values from universal model predictions are associated to effective range corrections. The effective range correction is extracted, with a weighted average given by 3.9$\pm 0.8 R_{vdW}$, where $R_{vdW}$ is the van der Waals length scale; which is consistent with the van der Waals potential tail for the $Cs_2$ system. The method can be generally applied to other cold atom experimental setups to determine the contribution of the effective range to the tetramer dissociation position.Comment: A section for two-, three- and four-boson bound state formalism is added, accepted for publication in Phys. Rev.

Scaling functions of two-neutron separation energies of 20C^{20}C with finite range potentials

The behaviour of an Efimov excited state is studied within a three-body Faddeev formalism for a general neutron-neutron-core system, where neutron-core is bound and neutron-neutron is unbound, by considering zero-ranged as well as finite-ranged two-body interactions. For the finite-ranged interactions we have considered a one-term separable Yamaguchi potential. The main objective is to study range corrections in a scaling approach, with focus in the exotic carbon halo nucleus $^{20}C$

Disentangling dark sector models using weak lensing statistics

We perform multi-plane ray-tracing using the GLAMER gravitational lensing code within high-resolution light-cones extracted from the CoDECS simulations: a suite of cosmological runs featuring a coupling between Dark Energy and Cold Dark Matter. We show that the presence of the coupling is evident not only in the redshift evolution of the normalisation of the convergence power spectrum, but also in differences in non-linear structure formation with respect to {\Lambda}CDM. Using a tomographic approach under the assumption of a {\Lambda}CDM cosmology, we demonstrate that weak lensing measurements would result in a {\sigma}8 value that changes with the source redshift if the true underlying cosmology is a coupled Dark Energy one. This provides a generic null test for these types of models. We also find that different models of coupled Dark Energy can show either an enhanced or a suppressed correlation between convergence maps with differing source redshifts as compared to {\Lambda}CDM. This would provide a direct way to discriminate between different possible realisations of the coupled Dark Energy scenario. Finally, we discuss the impact of the coupling on several lensing observables for different source redshifts and angular scales with realistic source redshift distributions for current ground-based and future space-based lensing surveys.Comment: 17 pag. and 14 fig. replaced to match the accepted version (increased the number of light-cone realisations

Update on chronic rejection after intestinal transplant. An overview from experimental settings to clinical outcomes

Chronic rejection affects the long-term survival of solid-organ transplants, accounting for an incidence of between 5% and 10% after intestinal/multivisceral transplant. Because of unclear symptoms and signs and endoscopic findings, the diagnosis is often delayed. Presently, allograft removal represents the only available therapy due to the absence of effective pharmacologic approaches. Extensive research, through animal models, has been performed over the past 20 years to clarify the complex immune- and nonimmune-mediated mechanisms behind the development of chronic allograft enteropathy, with the aim of elucidating how to avert chronic rejection. The role of donor-specific antibodies and the way to challenge them in the clinic have gained acceptance among transplant centers as one of the main steps to prevent chronic rejection, although no common protocol exists that can be applied in a systematic fashion. The adjunct of a liver graft when retrans planting is needed in a sensitized recipient due to its protective effect against humoral immunity. Multicenter studies and clinical trials are required to better understand the pathogenesis of chronic rejection and to find the therapeutic answer to this clinical query

Light storage protocols in Tm:YAG

We present two quantum memory protocols for solids: A stopped light approach based on spectral hole burning and the storage in an atomic frequency comb. These procedures are well adapted to the rare-earth ion doped crystals. We carefully clarify the critical steps of both. On one side, we show that the slowing-down due to hole-burning is sufficient to produce a complete mapping of field into the atomic system. On the other side, we explain the storage and retrieval mechanism of the Atomic Frequency Comb protocol. This two important stages are implemented experimentally in Tm$^{3+}$- doped yttrium-aluminum-garnet crystal