LISA data analysis: The monochromatic binary detection and initial guess problems

We consider the detection and initial guess problems for the LISA gravitational wave detector. The detection problem is the problem of how to determine if there is a signal present in instrumental data and how to identify it. Because of the Doppler and plane-precession spreading of the spectral power of the LISA signal, the usual power spectrum approach to detection will have difficulty identifying sources. A better method must be found. The initial guess problem involves how to generate {\it a priori} values for the parameters of a parameter-estimation problem that are close enough to the final values for a linear least-squares estimator to converge to the correct result. A useful approach to simultaneously solving the detection and initial guess problems for LISA is to divide the sky into many pixels and to demodulate the Doppler spreading for each set of pixel coordinates. The demodulated power spectra may then be searched for spectral features. We demonstrate that the procedure works well as a first step in the search for gravitational waves from monochromatic binaries.Comment: 8 pages, 8 figure

LISA Measurement of Gravitational Wave Background Anisotropy: Hexadecapole Moment via a Correlation Analysis

We discuss spatial fluctuations in the gravitational wave background arising from unresolved Galactic binary sources, such as close white dwarf binaries, due to the fact the galactic binary source distribution is anisotropic. We introduce a correlation analysis of the two data streams of the Laser Interferometer Space Antenna (LISA) to extract spherical harmonic coefficients, in an independent manner, of the hexadecapole moment ($l=4$) related to the projected two-dimensional density distribution of the binary source population. The proposed technique complements and improves over previous suggestions in the literature to measure the gravitational wave background anisotropy based on the time modulation of data as LISA orbits around the Sun. Such techniques, however, are restricted only to certain combinations of spherical harmonic coefficients of the galaxy with no ability to separate them individually. With LISA, $m=2,3$ and 4 coefficients of the hexadecapole ($l=4$) can be measured with signal-to-noise ratios at the level of 10 and above in a certain coordinate system. In addition to the hexadecapole coefficients, when combined with the time modulation analysis, the correlation study can also be used, in principle, to measure quadrupole coefficients of the binary distribution.Comment: 8 pages, 2 figure

Low Frequency Gravitational Waves from White Dwarf MACHO Binaries

The possibility that Galactic halo MACHOs are white dwarfs has recently attracted much attention. Using the known properties of white dwarf binaries in the Galactic disk as a model, we estimate the possible contribution of halo white dwarf binaries to the low-frequency (10^{-5} Hz} < f < 10^{-1}Hz) gravitational wave background. Assuming the fraction of white dwarfs in binaries is the same in the halo as in the disk, we find the confusion background from halo white dwarf binaries could be five times stronger than the expected contribution from Galactic disk binaries, dominating the response of the proposed space based interferometer LISA. Low-frequency gravitational wave observations will be the key to discovering the nature of the dark MACHO binary population.Comment: 9 pages, 1 figure, AASTe

Probing anisotropies of gravitational-wave backgroundswith a space-based interferometer II: Perturbative reconstruction of a low-frequency skymap

We present a perturbative reconstruction method to make a skymap of gravitational-wave backgrounds (GWBs) observed via space-based interferometer. In the presence of anisotropies in GWBs, the cross-correlated signals of observed GWBs are inherently time-dependent due to the non-stationarity of the gravitational-wave detector. Since the cross-correlated signal is obtained through an all-sky integral of primary signals convolving with the antenna pattern function of gravitational-wave detectors, the non-stationarity of cross-correlated signals, together with full knowledge of antenna pattern functions, can be used to reconstruct an intensity map of the GWBs. Here, we give two simple methods to reconstruct a skymap of GWBs based on the perturbative expansion in low-frequency regime. The first one is based on harmonic-Fourier representation of data streams and the second is based on "direct" time-series data. The latter method enables us to create a skymap in a direct manner. The reconstruction technique is demonstrated in the case of the Galactic gravitational wave background observed via planned space interferometer, LISA. Although the angular resolution of low-frequency skymap is rather restricted, the methodology presented here would be helpful in discriminating the GWBs of galactic origins by those of the extragalactic and/or cosmological origins.Comment: 23 pages, 12 figures, Phys.Rev.D (2005) in pres

A constitutive model for the mechanical response of the folding of creased paperboard

AbstractPaperboard is a widely used material in industrial processes, in particular for packaging purposes. Packages are obtained through a forming process, in which a flat laminated sheet is converted into the final 3-D solid. In the package forming process, it is common practice to score the paperboard laminate with crease lines, in order to obtain folds with sharp edges and to minimize the initiation and propagation of flaws during the subsequent folding procedures. In this work, a constitutive model for the mechanical response of crease lines is proposed and validated on the basis of experimental tests available in the literature. The model has been implemented in an interface finite element to be placed between adjacent shell elements and is intended for large-scale computations of package forming processes. For this reason, the material model has been developed at the macroscopic scale in terms of generalized variables, aiming at computational effectiveness

Elimination of Clock Jitter Noise in Spaceborn Laser Interferometers

Space gravitational wave detectors employing laser interferometry between free-flying spacecraft differ in many ways from their laboratory counterparts. Among these differences is the fact that, in space, the end-masses will be moving relative to each other. This creates a problem by inducing a Doppler shift between the incoming and outgoing frequencies. The resulting beat frequency is so high that its phase cannot be read to sufficient accuracy when referenced to state-of-the-art space-qualified clocks. This is the problem that is addressed in this paper. We introduce a set of time-domain algorithms in which the effects of clock jitter are exactly canceled. The method employs the two-color laser approach that has been previously proposed, but avoids the singularities that arise in the previous frequency-domain algorithms. In addition, several practical aspects of the laser and clock noise cancellation schemes are addressed.Comment: 20 pages, 5 figure

Study of wound healing dynamics by single pseudo-particle tracking in phase contrast images acquired in time-lapse

Cellular contacts modify the way cells migrate in a cohesive group with respect to a free single cell. The resulting motion is persistent and correlated, with cells’ velocities self-aligning in time. The presence of a dense agglomerate of cells makes the application of single particle tracking techniques to define cells dynamics difficult, especially in the case of phase contrast images. Here, we propose an original pipeline for the analysis of phase contrast images of the wound healing scratch assay acquired in time-lapse, with the aim of extracting single particle trajectories describing the dynamics of the wound closure. In such an approach, the membrane of the cells at the border of the wound is taken as a unicum, i.e., the wound edge, and the dynamics is described by the stochastic motion of an ensemble of points on such a membrane, i.e., pseudo-particles. For each single frame, the pipeline of analysis includes: first, a texture classification for separating the background from the cells and for identifying the wound edge; second, the computation of the coordinates of the ensemble of pseudo-particles, chosen to be uniformly distributed along the length of the wound edge. We show the results of this method applied to a glioma cell line (T98G) performing a wound healing scratch assay without external stimuli. We discuss the efficiency of the method to assess cell motility and possible applications to other experimental layouts, such as single cell motion. The pipeline is developed in the Python language and is available upon request

Study of Wound Healing Dynamics by Single Pseudo-Particle Tracking in Phase Contrast Images Acquired in Time-Lapse

Cellular contacts modify the way cells migrate in a cohesive group with respect to a free single cell. The resulting motion is persistent and correlated, with cells’ velocities self-aligning in time. The presence of a dense agglomerate of cells makes the application of single particle tracking techniques to define cells dynamics difficult, especially in the case of phase contrast images. Here, we propose an original pipeline for the analysis of phase contrast images of the wound healing scratch assay acquired in time-lapse, with the aim of extracting single particle trajectories describing the dynamics of the wound closure. In such an approach, the membrane of the cells at the border of the wound is taken as a unicum, i.e., the wound edge, and the dynamics is described by the stochastic motion of an ensemble of points on such a membrane, i.e., pseudo-particles. For each single frame, the pipeline of analysis includes: first, a texture classification for separating the background from the cells and for identifying the wound edge; second, the computation of the coordinates of the ensemble of pseudo-particles, chosen to be uniformly distributed along the length of the wound edge. We show the results of this method applied to a glioma cell line (T98G) performing a wound healing scratch assay without external stimuli. We discuss the efficiency of the method to assess cell motility and possible applications to other experimental layouts, such as single cell motion. The pipeline is developed in the Python language and is available upon request.Basque Government BERC 2018– 2021 Spanish Ministry of Economy and Competitiveness MINECO via the BCAM Severo Ochoa SEV-2017-0718 accreditatio

Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab

Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone. Methods: K-RAS (exons 2, 3, 4) wild type colorectal cancer patients, candidates to second/third-line cetuximab with chemotherapy were prospectively allocated into 2 groups on the basis of their profile: favourable (BRAF and PIK3CA exon 20 wild type, EGFR GCN ≥ 2.6, HER-3 Rajkumar score ≤ 8, IGF-1 immunostaining < 2) or unfavourable (any of the previous markers altered or mutated). After the introduction of N-RAS status (exons 2, 3, 4) only RAS wild type patients were considered eligible. Results: Forty-six patients were enrolled. Seventeen patients (37%) were allocated to the favourable and 29 patients (63%) to the unfavourable profile. RR in the favourable and unfavourable group was 11/17 (65%) and 2/29 (7%) (p = 0.007) respectively. The favourable group also showed an improved PFS (8months vs. 3months, p < 0.0001) and OS (15months vs. 6months, p < 0.0001). Conclusions: Our results suggest that prospective selection of optimal candidates for cetuximab treatment is feasible and may be able to improve clinical outcom

Sensitivity curves for spaceborne gravitational wave interferometers

To determine whether particular sources of gravitational radiation will be detectable by a specific gravitational wave detector, it is necessary to know the sensitivity limits of the instrument. These instrumental sensitivities are often depicted (after averaging over source position and polarization) by graphing the minimal values of the gravitational wave amplitude detectable by the instrument versus the frequency of the gravitational wave. This paper describes in detail how to compute such a sensitivity curve given a set of specifications for a spaceborne laser interferometer gravitational wave observatory. Minor errors in the prior literature are corrected, and the first (mostly) analytic calculation of the gravitational wave transfer function is presented. Example sensitivity curve calculations are presented for the proposed LISA interferometer. We find that previous treatments of LISA have underestimated its sensitivity by a factor of $\sqrt{3}$.Comment: 27 pages + 5 figures, REVTeX, accepted for publication in Phys Rev D; Update reflects referees comments, figure 3 clarified, figure 5 corrected for LISA baselin