71 research outputs found
Magnetic properties of HO2 thin films
We report on the magnetic and transport studies of hafnium oxide thin films
grown by pulsed-laser deposition on sapphire substrates under different oxygen
pressures, ranging from 10-7 to 10-1 mbar. Some physical properties of these
thin films appear to depend on the oxygen pressure during growth: the film
grown at low oxygen pressure (P ~= 10-7 mbar) has a metallic aspect and is
conducting, with a positive Hall signal, while those grown under higher oxygen
pressures (7 x 10-5 <= P <= 0.4 mbar) are insulating. However, no intrinsic
ferromagnetic signal could be attributed to the HfO2 films, irrespective of the
oxygen pressure during the deposition.Comment: 1
Rare earth contributions to the X-ray magnetic circular dichroism at the Co K edge in rare earth-cobalt compounds investigated by multiple-scattering calculations
The X-ray magnetic circular dichroism (XMCD) has been measured at the Co K
edge in Co-hcp and R-Co compounds (R=La, Tb, Dy). The structure of the
experimental XMCD spectra in the near-edge region has been observed to be
highly sensitive to the magnetic environment of the absorbing site.
Calculations of the XMCD have been carried out at the Co K edge in Co metal,
LaCo and TbCo within the multiple-scattering framework including the
spin-orbit coupling. In the three systems, the XMCD spectra in the near-edge
region are well reproduced. The possibility to separate and quantitatively
estimate the local effects from those due to the neighboring atoms in the XMCD
cross section makes possible a more physical understanding of the spectra. The
present results emphasize the major role played by the states of the Tb
ions in the XMCD spectrum at the Co K edge in the TbCo compound.Comment: 34 pages, revtex, 10 eps figures included with epsf, after referee
revie
Improvement of the chondrocyte-specific phenotype upon equine bone marrow mesenchymal stem cell differentiation. Influence of TGF-Ă1 or TGF-Ă3, associated with BMP-2 and type I collagen siRNAs
International audienceArticular cartilage is a tissue characterized by its poor intrinsic capacity for self-repair. This tissue is frequently altered upon trauma or in osteoarthritis (OA), a degenerative disease that is currently incurable. Consequently, cartilage markers, such as type II collagen, are degraded whereas atypic molecules, such as type I collagen, are newly synthetized. Another essential phenomenon occurring in OA is the upregulation of HtrA1, a serine protease targeting upstream receptors of signalling pathways involved in the synthesis of articular cartilage markers. OA incurs considerable economic loss for the equine sector. In the view to develop new therapies for humans and horses, significant progress in tissue engineering has led to the emergence of new generations of cartilage therapy. Matrix-associated autologous chondrocyte implantation is an advanced 3D cell-based therapy that holds promise for cartilage repair. The aim of this study is to improve the autologous chondrocyte implantation strategy by enhancing the chondrogenic differentiation of mesenchymal stem cells (MSCs) in order to increase the type II collagen/ type I collagen ratio
Prediction of 7-year psychopathology from mother-infant joint attention behaviours: a nested caseâcontrol study
<br>Background: To investigate whether later diagnosis of psychiatric disorder can be predicted from analysis of mother-infant joint attention (JA) behaviours in social-communicative interaction at 12 months.</br>
<br>Method:
Using data from a large contemporary birth cohort, we examined 159 videos of a mother-infant interaction for joint attention behaviour when children were aged one year, sampled from within the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Fifty-three of the videos involved infants who were later considered to have a psychiatric disorder at seven years and 106 were same aged controls. Psychopathologies included in the case group were disruptive behaviour disorders, oppositional-conduct disorder, attention-deficit/hyperactivity disorder, pervasive development disorder, anxiety and depressive disorders. Psychiatric diagnoses were obtained using the Development and Wellbeing Assessment when the children were seven years old.</br> <br>Results: None of the three JA behaviours (shared look rate, shared attention rate and shared attention intensity) showed a significant association with the primary outcome of caseâcontrol status. Only shared look rate predicted any of the exploratory sub-diagnosis outcomes and was found to be positively associated with later oppositional-conduct disorders (OR [95% CI]: 1.5 [1.0, 2.3]; pâ=â0.041).</br><br>Conclusions: JA behaviours did not, in general, predict later psychopathology. However, shared look was positively associated with later oppositional-conduct disorders. This suggests that some features of JA may be early markers of later psychopathology. Further investigation will be required to determine whether any JA behaviours can be used to screen for families in need of intervention.</br>
The intergenerational association between parents' problem gambling and impulsivity-hyperactivity/inattention behaviors in children
Despite the well-established association between problem gambling and ADHD core categories of impulsivity-hyperactivity and inattention, the link between parentsâ problem gambling and impulsivity-hyperactivity/inattention (IH/I) behaviors in children has not been investigated. This study investigated the association between parentsâ problem gambling and childrenâs IH/I behaviors while controlling for potential confounding variables. A population-based prospective cohort followed-up from kindergarten to age 30, the Quebec Longitudinal Study of Kindergarten Children (QLSKC), provided data over three generations. Among 1358 participants at age 30, parents with a child aged 1 year or older (N=468; Mean age=4.65 years; SD=2.70) were selected. Generalized Linear Models included measures of grandparentsâ and parentsâ problem gambling, parentsâ IH/I behaviors in childhood, and a host of risk factors and comorbidities to predict IH/I in children. Intergenerational bivariate associations were observed between grandparentsâ problem gambling, parentsâ IH/I in childhood and problem gambling at age 30, and between parentsâ IH/I, problem gambling, and childrenâs IH/I behaviors. Parentsâ problem gambling predicted childrenâs IH/I behaviors above and beyond the effects of covariates such as family and socioeconomic characteristics, alcohol and drug use, depression symptoms and parentsâ gambling involvement. Parentsâ IH/I behaviors in childhood also predicted childrenâs IH/I and had a moderating, enhancing effect on parentsâ problem gambling association with their offspringâs IH/I behaviors. Problem gambling is a characteristic of parentsâ mental health that is distinctively associated with childrenâs IH/I behaviors, above and beyond parentsâ own history of IH/I and of typically related addictive, psychopathological or socioeconomic risk factors and comorbidities
Face scanning and spontaneous emotion preference in Cornelia de Lange syndrome and Rubinstein-Taybi syndrome
Background
Existing literature suggests differences in face scanning in individuals with different socio-behavioural characteristics. Cornelia de Lange syndrome (CdLS) and Rubinstein-Taybi syndrome (RTS) are two genetically defined neurodevelopmental disorders with unique profiles of social behaviour.
Methods
Here, we examine eye gaze to the eye and mouth regions of neutrally expressive faces, as well as the spontaneous visual preference for happy and disgusted facial expressions compared to neutral faces, in individuals with CdLS versus RTS.
Results
Results indicate that the amount of time spent looking at the eye and mouth regions of faces was similar in 15 individuals with CdLS and 17 individuals with RTS. Both participant groups also showed a similar pattern of spontaneous visual preference for emotions.
Conclusions
These results provide insight into two rare, genetically defined neurodevelopmental disorders that have been reported to exhibit contrasting socio-behavioural characteristics and suggest that differences in social behaviour may not be sufficient to predict attention to the eye region of faces. These results also suggest that differences in the social behaviours of these two groups may be cognitively mediated rather than subcortically mediated
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