Pragas com potencial quarentenário para a cultura da cana-de-açúcar.

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Pragas com potencial quarentenário para culturas oleaginosas envolvidas na produção da agroenergia.

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Scenarios for the future Brazilian power sector based on a multi-criteria assessment

The Brazilian power generation sector faces a paradigm change driven by, on one hand, a shift from a hydropower dominated mix and, on the other hand, international goals for reducing greenhouse gas emissions. The objective of this work is to evaluate five scenarios for the Brazilian power sector until 2050 using a multi-criteria decision analysis tool. These scenarios include a baseline trend and low carbon policy scenarios based on carbon taxes and carbon emission limits. To support the applied methodology, a questionnaire was elaborated to integrate the perceptions of experts on the scenario evaluation process. Considering the results from multi-criteria analysis, scenario preference followed the order of increasing share of renewables in the power sector. The preferable option for the future Brazilian power sector is a scenario where wind and biomass have a major contribution. The robustness of the multi-criteria tool applied in this study was tested by a sensitivity analysis. This analysis demonstrated that, regardless of the respondents' preferences and backgrounds, scenarios with higher shares of fossil fuel sources are the least preferable option, while scenarios with major contributions from wind and biomass are the preferable option to supply electricity in Brazil through 2050.The research that allowed the publication of this paper has been produced with the financial assistance of the European Union in the context of the CLIMACAP project (EuropeAid/131944/C/SER/Multi) and of the U.S. Agency for International Development and U.S. Environmental Protection Agency in the context of the LAMP project (under Interagency Agreements DW89923040 and DW89923951US). The contents of this publication are the sole responsibility of the authors and can in no way be taken to reflect the views of the European Union or the U.S. government. The authors would like to thank the feedback and efforts from all CLIMACAP and LAMP project partners for enabling the research results reported in this article. This research was also supported by a Marie Curie International Research Staff Exchange Scheme Fellowship within the 7th European Union Framework Programme, under project NETEP-European Brazilian Network on Energy Planning (PIRSES-GA-2013-612263).info:eu-repo/semantics/publishedVersio

HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors

Persistent HPV infection alone is not sufficient for cervical cancer development, which requires additional molecular alterations for tumor progression and metastasis ultimately leading to a lethal disease. In this study, we performed a comprehensive analysis of HER family receptor alterations in cervical adenocarcinoma. We detected overexpression of HER protein, mainly HER2, which was an independent prognostic marker for these patients. By using in vitro and in vivo approaches, we provided evidence that HER inhibitors, allitinib and lapatinib, were effective in reducing cervical cancer aggressiveness. Furthermore, combination of these drugs with glucose uptake blockers could overcome the putative HIF1-a-mediated resistance to HER-targeted therapies. Thus, we propose that the use of HER inhibitors in association with glycolysis blockers can be a potentially effective treatment option for HER-positive cervical cancer patients.FINEP (MCTI/FINEP/MS/SCTIE/DECIT-BIOPLAT (1302/13), Brazil and co-funded by the project “ON.2 SR&TD Integrated Program (NORTE-07-0124-FEDER-000017)” co-funded by Programa Operacional Regional do Norte (ON.2- O Novo Norte), Quadro de Referência Estratégico Nacional (QREN), through Fundo Europeu de Desenvolvimento Regional (FEDER). OM is recipient of a post-doc fellowship (SFRH/BPD/108351/2015) from Fundação para a Ciência e Tecnologia (FCT), Portugal. FC is recipient of a master fellowship (2014/03684-0) from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). VMG is recipient from a PhD fellowship (SFRH/BD/51997/2012) from Fundação para a Ciência e Tecnologia (FCT), Portugalinfo:eu-repo/semantics/publishedVersio

Performance of Beef Cattle Fed Diets Containing \u3cem\u3eStylosanthes\u3c/em\u3e and Corn Silages

Reports of the use of tropical legumes in silage production are scarce as these legumes have high contents of crude protein, low water soluble carbohydrate and high buffering capacity, which inhibit the production of silages with good fermentation and nutritional characteristics. Recent research has, however, shown that it is possible to produce good quality silages using tropical legumes (Pereira et al. 2012). Souza et al. (2012) concluded that silage produced from Stylosanthes cv. Campo Grande (Stylosanthes capitata + Stylosanthes macrocephala) at 60% proportion of the dry matter of the diet can replace corn silage in diets for beef cattle in feedlots without altering their intake and productive performance. However, the ideal proportion of this silage in the diets for beef cattle is still unknown. Thus, the objective of this study was to evaluate the intake and performance of beef cattle fed diets with Stylosanthes and corn silages

Ionic liquid-mediated recovery of carotenoids from the bactris gasipaes fruit waste and their application in food-packaging chitosan films

In this work, a process for the extraction and purification of carotenoids from the fruit Bactris gasipaes was developed. Ethanolic and aqueous solutions of ionic liquids (ILs) and surfactants were evaluated on the extraction of these pigments. Thus, we developed an optimized sustainable downstream process mediated by the best solvent with further isolation of the carotenoids and the recyclability of the IL used. The process was characterized not only in terms of efficiency but also regarding its environmental impact. The recyclability of the solvents as well as the high efficiency (maximum yield of extraction of carotenoids = 88.7 ± 0.9 μgcarotenoids·gdried biomass–1) and the low environmental impact of the integrated process developed in this work were demonstrated. In the end, in order to incorporate functional activity for an alternative food-packaging material, carotenoids were successfully applied on the preparation of chitosan-based films with excellent results regarding their mechanical parameters and antioxidant activity.publishe

Pragas com potencial quarentenário para a cultura envolvidas na produção de biodiesel.

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The influence of polysaccharide coating on the physicochemical parameters and cytotoxicity of silica nanoparticles for hydrophilic biomolecules delivery

The present work reports the effect of polysaccharides (chitosan and sodium alginate) on silica nanoparticles (SiNP) for hydrophilic molecules delivery taking insulin as model drug. The influence of tetraethyl orthosilicate (TEOS) and homogenization speed on SiNP properties was assessed by a 22 factorial design achieving as optimal parameters: 0.43 mol/L of TEOS and homogenization speed of 5000 rpm. SiNP mean particle size (Z-Ave) was of 256.6 nm and polydispersity index (PI) of 0.218. SiNP coated with chitosan (SiNP-CH) or sodium alginate (SiNP-SA) increased insulin association efficacy; reaching 84.6% (SiNP-SA) and 90.8% (SiNP-CH). However, coated SiNP released 50%–60% of the peptide during the first 45 min at acidic environment, while uncoated SiNP only released 30%. Similar results were obtained at pH 6.8. The low Akaike’s (AIC) values indicated that drug release followed Peppas model for SiNP-SA and second order for uncoated SiNP and SiNP-CH (pH 2.0). At pH 6.8, the best fitting was Boltzmann for Ins-SiNP. However, SiNP-CH and SiNP-SA showed a first-order behavior. Cytotoxicity of nanoparticles, assessed in Caco-2 and HepG2 cells, showed that 100 to 500 µg/mL SiNP-CH and SiNP-SA slightly decreased cell viability, comparing with SiNP. In conclusion, coating SiNP with selected polysaccharides influenced the nanoparticles physicochemical properties, the insulin release, and the effect of these nanoparticles on cell viability.This research was supported by the Fundação para a Ciência e Tecnologia (FCT, Portugal), by grating PhD scholarships SFRH/BD/60640/2009 (T. Andreani), SFRH/BD/80335/2011 (J.F. Fangueiro) and SFRH/BD/111274/2015 (P.M.V. Fernandes), and funded projects UID/AGR/04033/2019 (CITAB), and M-ERANET/0004/2015-PAIRED (Partnership Agreement PT2020).info:eu-repo/semantics/publishedVersio

The influence of regular physical activity on the self-concept

Foi objetivo desta pesquisa estudar a influência da atividade física regular de homens e mulheres de mais de 40 anos sobre o seu autoconceito. A Escala Fatorial de Autoconceito foi administrada a 200 sujeitos, metade deles praticando algum tipo de atividade física regular no momento da pesquisa e a outra metade sendo sedentários. A Anova 2X2 revelou efeito principal da atividade física regular e do gênero sobre vários fatores do autoconceito. Os escores foram superiores em autoconfiança, autocontrole e self somático para o grupo experimental e no self ético-moral para as mulheres. Conclui-se que a atividade física regular tem impacto benéfico sobre o autoconceito.The objective of this research was to study the effect of regular physical activity of men and women over 40 on their self-concept. The Self-concept Factorial Scale was administered to 200 subjects, half of them practicing some kind of regular physical activity and the other half being sedentary. The Anova 2X2 revealed a main effect of physical activity and gender on several factors of the self-concept. The scores were higher for the experimental group on self-confidence, self-control, and somatic self. Men scored higher on self-confidence while women on moral self. It was concluded that regular physical activity is beneficial for self-concept