3,356 research outputs found

    Recent Decisions

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    1 Corinthians and Work

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    Introduction to 1 Corinthians All are called (1 Cor 1:1-3) Spiritual Resources Available (1 Cor 1:4-9) The Need for a Common Vision (1 Cor 1:10-17) Friends in Low Places (1 Cor 1:18-31) It Takes All Sorts (1 Cor 3:1-9) Do Good Work (1 Cor 3:10-17) Leadership as Service (1 Cor 4:1-4) Working with Nonbelievers (1 Cor 5:9-10) Bloom Where You are Planted (1 Cor 7:20-24) Maintain the Proper Perspective (1 Cor 7:29-31) Everyone Gets Their Fair Share (1 Cor 9:7-10) God\u27s Glory is the Ultimate Goal (1 Cor 8 & 10) Gifted Communities (1 Cor 12:1-14:40) Our Work is Not in Vain (1 Cor 15:58) We Share Our Resources with Those in Hardship (1 Cor 16:1-3) Summary to 1 Corinthians Key Verses and Themes in 1 Corinthian

    2 Corinthians and Work

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    Introduction to 2 Corinthians Thank God for Relationships (2 Corinthians 1:1-11) Transparency (2 Corinthians 1:12-23) Working for the Joy of Others (2 Corinthians 1:24) The Priority of Relationships (2 Corinthians 2:12-16) Sincerity (2 Corinthians 2:17) A Genuine Reputation (2 Corinthians 3) Leading and Serving (2 Corinthians 4) Performance and Accountability (2 Corinthians 5:1-15) Reconciling the Whole World (2 Corinthians 5:16-21) Transparency Revisited (2 Corinthians 6:11) Working with Nonbelievers (2 Corinthians 6:14-18) The Encouragement of Praise (2 Corinthians 7) Generosity Is Not Optional (2 Corinthians 8:1-9) Timely Fulfillment of Obligations (2 Corinthians 8:10-12) Sharing the Wealth (2 Corinthians 8:13-15) You Can\u27t Out-Give God (2 Corinthians 9) Assessing Performance (2 Corinthians 10-13) Conclusion to 2 Corinthians Key Verses and Themes in 2 Corinthian

    Exclusionary employment in Britain’s broken labour market

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    There is growing evidence of the problematic nature of the UK’s ‘flexible labour market’ with rising levels of in-work poverty and insecurity. Yet successive Governments have stressed that paid work is the route to inclusion, focussing attention on the divide between employed and unemployed. Past efforts to measure social exclusion have tended to make the same distinction. The aim of this paper is to apply Levitas et al’s (2007) framework to assess levels of exclusionary employment, i.e. exclusion arising directly from an individual’s labour market situation. Using data from the Poverty and Social Exclusion UK survey, results show that one in three adults in paid work is in poverty, or in insecure or poor quality employment. One third of this group have not seen any progression in their labour market situation in the last five years. The policy focus needs to shift from ‘Broken Britain’ to Britain’s broken labour market

    Disability Costs and Equivalence Scales in the Older Population in Great Britain

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    We use a standard of living (SoL) approach to estimate older people's disability costs, using data on 8000 individuals from the U.K. Family Resources Survey. We extend previous research in two ways. First, by allowing for a more flexible relationship between SoL and income, the structure of the estimated disability cost and equivalence scale is not dictated by a restrictive functional form assumption. Second, we allow for the latent nature of disability and SoL, addressing measurement error in the disability and SoL indicators in surveys. We find that disability costs are strongly related to severity of disability, and vary with income in absolute and proportionate terms. Older people above the median disability level require an extra �99 per week (2007 prices) on average to reach the SoL of an otherwise similar person at the median. Costs faced by older people in the highest decile of disability average �180

    Scholarly use of social media and altmetrics : a review of the literature

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    Social media has become integrated into the fabric of the scholarly communication system in fundamental ways: principally through scholarly use of social media platforms and the promotion of new indicators on the basis of interactions with these platforms. Research and scholarship in this area has accelerated since the coining and subsequent advocacy for altmetrics—that is, research indicators based on social media activity. This review provides an extensive account of the state-of-the art in both scholarly use of social media and altmetrics. The review consists of two main parts: the first examines the use of social media in academia, examining the various functions these platforms have in the scholarly communication process and the factors that affect this use. The second part reviews empirical studies of altmetrics, discussing the various interpretations of altmetrics, data collection and methodological limitations, and differences according to platform. The review ends with a critical discussion of the implications of this transformation in the scholarly communication system

    Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells

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    Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the ligand of DNAM1 activating receptor, PVR, undergoes SUMOylation in multiple myeloma. Concurrently, we found that PVR is preferentially located in intracellular compartments in human multiple myeloma cell lines and malignant plasma cells and that inhibition of the SUMO pathway promotes its translocation to the cell surface, increasing tumor cell susceptibility to NK cell-mediated cytolysis. Our findings provide the first evidence of an innate immune activating ligand regulated by SUMOylation, and confer to this modification a novel role in impairing recognition and killing of tumor cells.Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the ligand of DNAM1 activating receptor, PVR, undergoes SUMOylation in multiple myeloma. Concurrently, we found that PVR is preferentially located in intracellular compartments in human multiple myeloma cell lines and malignant plasma cells and that inhibition of the SUMO pathway promotes its translocation to the cell surface, increasing tumor cell susceptibility to NK cell-mediated cytolysis. Our findings provide the first evidence of an innate immune activating ligand regulated by SUMOylation, and confer to this modification a novel role in impairing recognition and killing of tumor cells

    Biostratigraphy of Middle and Late Pennsylvanian (Desmoinesian-Virgilian) ammonoids

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    New stratigraphic ranges for genera of Desmoinesian-Virgilian ammonoids are presented, based on analysis of 40,000 specimens collected from over 70 ammonoid-bearing horizons that represent at least 40 successive stratigraphic levels in the North American midcontinent. These range revisions indicate that current generic-level ammonoid zonations are inadequate, especially for correlation of Pennsylvanian series and stage boundaries. Six high-confidence, largely generic-level first-occurrence zones are proposed for the Desmoinesian through Virgilian stages: Wellerites Zone, Eothalassoceras Zone, Pennoceras Zone, Preshumardites Zone, Pseudaktubites Zone, and Shumardites Zone. Fifteen zones of lesser confidence for correlation are also suggested. The Shumarditidae Plummer & Scott, 1937, is emended to include Preshumardites Plummer & Scott, 1937, Pseudaktubites gen. nov. (type species, Preshumardites stainbrooki Plummer & Scott, 1937), and Shumardites Smith, 1903. Early Permian (Sakmarian) species previously assigned to Preshumardites are reassigned to Andrianovia gen. nov. (type species ?Preshumardites sakmarae Ruzhencev, 1938). Aktubites Ruzhencev, 1955, Eoshumardites Popov, 1960, and Parashumardites Ruzhencev, 1939, previously included in the Shumarditidae, are assigned to the new family Parashumarditidae. Eovidrioceras inexpectans gen. nov., sp. nov. is included and is interpreted as the ancestor of the cyclobacean family Vidrioceratidae Plummer & Scott, 1937. The base of the revised Wellerites Zone, defined by the first occurrence of the nominate genus, approximates but does not coincide with the Atokan-Desmoinesian boundary. Recorrelation of the stratigraphic level of the Collinsville, Oklahoma, ammonoid locality from the "Seminole Formation" (basal Missourian) to the Holdenville Formation (upper Desmoinesian), based on lithostratigraphic evidence, effectively places the first occurrence of Eothalassoceras in the upper Desmoinesian. Because Wellerites apparently became extinct before the end of the Desmoinesian, the revised Eothalassoceras Zone is used to represent the upper Desmoinesian. The Middle-Upper Pennsylvanian boundary (Desmoinesian-Missourian boundary) can be recognized by the appearance of Pennoceras, which defines the base of the new Pennoceras Zone. The Pennoceras Zone is an excellent indicator of lower Missourian strata in the northern midcontinent, north-central Texas, the Marathon Uplift, and the Appalachian Basin. The new Preshumardites Zone occupies most of the upper part of the Missourian Stage. The appearance of the ancestral shumarditid Pseudaktubites, which defines the base of the new Pseudaktubites Zone, occurs one cycle below the Missourian-Virgilian boundary, which is currently recognized at the top of the South Bend Limestone Member in eastern Kansas. No recognizable biostratigraphic event coincides with the South Bend Member, thereby resulting in an uncorrelatable chronostratigraphic boundary. The largest changeover in ammonoid faunas takes place at the base of strata containing the upper part of the Pseudaktubites Zone (Pseudaktubites stainbrooki Subzone). The base of the Pseudaktubites stainbrooki Subzone is stratigraphically near the original Missourian-Virgilian boundary. It is recommended that the stratigraphic level containing the base of the Pseudaktubites stainbrooki Subzone be adopted as the official base of the Virgilian Stage. Recognition of the upper subzone of the Pseudaktubites Zone (Pseudaktubites stainbrooki Subzone) within the Colony Creek Shale Member in north-central Texas places the base of the Virgilian within the upper part of the Canyon Group and substantially below the current position at the Canyon-Cisco group boundary. Shumardites, a taxon previously used to mark the base of the Virgilian Stage, appears in early middle Virgilian strata; consequently, the revised Shumardites Zone represents the middle-upper Virgilian interval
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