103 research outputs found
Subjective well‐being and valuation of future health states : discrepancies between anticipated and experienced life satisfaction
One way of informing health policy decisions is to ask people about the impact that different health states would have on their future subjective well‐being. The present research explored the relation between anticipated and experienced changes in health‐related subjective well‐being, and examined whether affective forecasting errors could be reduced by psychological distancing manipulations. Using survey methodology, we tested whether people can accurately estimate the impact of different possible health states on their subjective well‐being. We also manipulated psychological distance: Forecasts were made about present self, future self, or others. Based on construal level theory and past work on affective forecasting errors, our prediction was that increasing psychological distance may reduce the mismatch between anticipated and experienced impact of health states on subjective well‐being. We found that the impact of ill health on subjective well‐being was greatly overpredicted and that this overprediction was not eliminated when participants were asked to make predictions about themselves in the future or about other people. Consistent with past work, we found that our participants correctly expected that their subjective well‐being would deteriorate more if they experienced the highest levels of mental illness as compared to the highest intensities of pain or most severe limitations to physical functioning
Fungal infections increase the mortality rate three-fold in necrotizing soft-tissue infections
Extraction of shear viscosity in stationary states of relativistic particle systems
Starting from a classical picture of shear viscosity we construct a
stationary velocity gradient in a microscopic parton cascade. Employing the
Navier-Stokes ansatz we extract the shear viscosity coefficient . For
elastic isotropic scatterings we find an excellent agreement with the analytic
values. This confirms the applicability of this method. Furthermore for both
elastic and inelastic scatterings with pQCD based cross sections we extract the
shear viscosity coefficient for a pure gluonic system and find a good
agreement with already published calculations.Comment: 17 pages, 7 figure
Eficiência de fungicidas para controle de giberela em trigo: resultados dos ensaios cooperativos - safra 2011.
O conjunto de ensaios instalados permitiu avaliar a eficiência de fungicidas no controle de giberela em diferentes níveis de ocorrência da doença. Considerando a variável composta índice de Giberela e os três locais de maior ocorrência de giberela (Castro - PR, Guarapuava - PR e Cruz Alta - RS) todos os fungicidas testados foram capazes de reduzir a ocorrência de giberela. Ainda considerando este conjunto de dados, a redução na ocorrência da doença implicou em maior manutenção da produtividade. Dada a interação observada entre tratamentos e ambiente, que levou a diferentes níveis de doença e de controle, e ainda considerando os dados de rendimento de grãos, não se pode concluir, neste primeiro ano de ensaios, que algum dos fungicidas utilizados seja indubitavelmente superior aos demais e com alta eficiência no controle de giberela do trigo.bitstream/item/72717/1/co-23-2012.pd
Structural Disorder Provides Increased Adaptability for Vesicle Trafficking Pathways
Vesicle trafficking systems play essential roles in the communication between the organelles of eukaryotic cells and also
between cells and their environment. Endocytosis and the late secretory route are mediated by clathrin-coated vesicles,
while the COat Protein I and II (COPI and COPII) routes stand for the bidirectional traffic between the ER and the Golgi
apparatus. Despite similar fundamental organizations, the molecular machinery, functions, and evolutionary characteristics
of the three systems are very different. In this work, we compiled the basic functional protein groups of the three main
routes for human and yeast and analyzed them from the structural disorder perspective. We found similar overall disorder
content in yeast and human proteins, confirming the well-conserved nature of these systems. Most functional groups
contain highly disordered proteins, supporting the general importance of structural disorder in these routes, although some
of them seem to heavily rely on disorder, while others do not. Interestingly, the clathrin system is significantly more
disordered (,23%) than the other two, COPI (,9%) and COPII (,8%). We show that this structural phenomenon enhances
the inherent plasticity and increased evolutionary adaptability of the clathrin system, which distinguishes it from the other
two routes. Since multi-functionality (moonlighting) is indicative of both plasticity and adaptability, we studied its
prevalence in vesicle trafficking proteins and correlated it with structural disorder. Clathrin adaptors have the highest
capability for moonlighting while also comprising the most highly disordered members. The ability to acquire tissue specific
functions was also used to approach adaptability: clathrin route genes have the most tissue specific exons encoding for
protein segments enriched in structural disorder and interaction sites. Overall, our results confirm the general importance of
structural disorder in vesicle trafficking and suggest major roles for this structural property in shaping the differences of
evolutionary adaptability in the three routes
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