Ethical Terms and its Usages in Tamil Scientific Journals

Magazines are the best mass media in the modern world.  Magazines are the tools for knowledge development and entertainment. There are certain journals that can stimulate scientific and moral awareness. In particular, we can mention the magazines Ariga Ariviyal Kalakathir, Suthrusulal Puthiya Ksalvi, Ariviyal oli and Thulir. The readers of scientific journals are not only from the scientific field but also from the public sector, students and non-students. Journalism and science are changing together to keep up with the progression and development of ideas. However, scientific journals are published regularly and are doing the work of moral awareness. In this article, the study information about the terminology related to moral theory that was recorded in two magazines, Arigal Ariviyal and Ariviyal Oli are provided.  In these 683 articles published in selected scientific journals from 2015 to 2019 and a total of 4546 articles were published depending on the fields of science. It also contains many moral words and thus 70 words were selected.  Nowadays, these words are mostly used by the public in English. These terms can be brought into public use through proper awareness

Characterization and analysis of Gomphonema sp frustule based on SEM/EDS

1576-1579Diatoms are unicellular algae whose cell wall structure is mainly made up of silicon dioxide (SiO2). Frustules were extracted from fresh diatom taxa (Gomphonema sp.) by treating with concentrated HNO3 and HCl. The Scanning electron microscope (SEM) images revealed that the diatoms have a valve asymmetrical to apical axis and raphe system is well developed and are unequal size. From significance of energy dispersive X - ray spectroscopy (EDS) examination it was proved that the frustules from diatoms are mainly made up of silicon through amorphous silica (SiO2)

Association of DNA damage and dyslipidemia with polycystic ovarian syndrome

Polycystic ovary syndrome (PCOS) is associated with hyperinsuli-nemia and insulin resistance which may lead to cardiovascular diseases. Evidence for cardiovascular events in women who were affected by PCOS during fertile age is limited. The pathogenesis is unknown; however, it is a complex multigenetic disorder. The present study was undertaken to evaluate the various cardiovas-cular risk factors and their DNA repair efficiency in women with PCOS by investigating the biochemical, endocrinological and mo-lecular cytogenetic alterations. These investigations were carried out in 116 women in the age group of 15-35 years clinically diag-nosed with PCOS. Data were compared with that of 50 age-matched healthy normal women. Fasting blood sugar (FBS), Lipid profile, Follicle-Stimulating Hormone (FSH) and Luteinizing Hor-mone (LH), Prolactin and Estradiol were estimated after getting the informed consent. Mutagen induced chromosome sensitivity analysis was carried out in the lymphocytes of the subjects to as-sess the DNA repair proficiency. Fasting Blood Sugar, total cho-lesterol and LDL cholesterol were found to be elevated whereas HDL cholesterol was found to be lowered in the test subjects. FSH, LH and prolactin were also found to be significantly elevated in the test subjects. Change in the estradiol concentration in the test subjects was not significant. The mutagen sensitivity analysis revealed a significant elevation in break per cell (b/c) values indi-cating a deficiency in the DNA repair mechanism / DNA damage in PCOS patients. Modification of life style by changing the dietary habit and sedentary life style will help to reduce the oxidative stress and may increase the ovarian function and a sensible life-style management is recommended for reducing the risk for CVD

Nutritional assessment and bioactive potential of Sargassum polycystum C. Agardh (Brown Seaweed)

492-498The phytochemical screening, nutritional composition and bioactive potential of Sargassum polycystum (Brown Seaweed) were investigated. The bioactive compounds of Sargassum polycystum showed significant activity against four human pathogens, namely, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. The biochemical composition of Sargassum polycystum exhibited high nutritional potential of protein (14.2%), carbohydrate (25.0%), lipid (7.6%), fiber (21.3%), and ash (29.0%) than that in terrestrial plants and animal products. The Sargassum polycystum could be providing more opportunities for discovering new drugs which may be used as a source of healthy food for human regular diet

Toward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins

Glycosaminoglycans (GAGs) interact with many proteins to regulate processes such as hemostasis, cell adhesion, growth and differentiation and viral infection. Yet, majority of these interactions remain poorly understood at a molecular level. A major reason for this state is the phenomenal structural diversity of GAGs, which has precluded analysis of specificity of their interactions. We had earlier presented a computational protocol for predicting “high-specificity” GAG sequences based on combinatorial virtual library screening (CVLS) technology. In this work, we expand the robustness of this technology through rigorous studies of parameters affecting GAG recognition of proteins, especially antithrombin and thrombin. The CVLS approach involves automated construction of a virtual library of all possible oligosaccharide sequences (di- to octasaccharide) followed by a two-step selection strategy consisting of “affinity” (GOLD score) and “specificity” (consistency of binding) filters. We find that “specificity” features are optimally evaluated using 100 genetic algorithm experiments, 100,000 evolutions and variable docking radius from 10 Å (disaccharide) to 14 Å (hexasaccharide). The results highlight critical interactions in H/HS oligosaccharides that govern specificity. Application of CVLS technology to the antithrombin–heparin system indicates that the minimal “specificity” element is the GlcAp(1 → 4)GlcNp2S3S disaccharide of heparin. The CVLS technology affords a simple, intuitive framework for the design of longer GAG sequences that can exhibit high “specificity” without resorting to exhaustive screening of millions of theoretical sequences

Taxonomy and Distribution of Scleria foliosa (Cyperaceae) in Kerala, India

Scleria foliosa (Cyperaceae) an interesting sedge species is reported here as a new record for Kerala. Detailed description with photographs and relevant notes on distribution are provided for easy identification

Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis

The mechanism of cell-cell contact dependent regulation of pericellular proteolysis in angiogenesis was examined by studying the expression of MMPs using isolated HUVECs in culture. Zymography, Immunoblot and RT-PCR analysis showed that the production and secretion of matrixmetalloproteinase-2 and matrixmetalloproteinase-9 by HUVECs in culture were high when they remain as individual cells and significantly decreased during later stages of culture when cells developed cell-cell contact and tubular network-like structure. As MMPs decreased there was significant upregulation of VE-cadherin in cells undergoing angiogenic transition. Investigations to understand the signaling pathways downstream of VE-cadherin showed a relatively high level of β-catenin in the nucleus of endothelial cells in culture during initial stages and decrease in its levels in the nucleus, associated with an increase in the cytosol during later stages of culture. The distribution of β-catenin was found to be regulated by Tyr/Ser phosphorylation status of this protein. Cell-cell contact dependent downregulation of MMPs during angiogenesis was also observed in experiments using proangiogenic substances which caused a rapid rate of downregulation of MMP-2 and MMP-9 and absence of downregulation of MMPs when treated with anti-angiogenic agents

Inclusion in neuroscience through high impact courses

Recognizing that STEM disciplines, including neuroscience, have a long way to go to attract and retain diverse talent, educators can take action by being more intentional about their departmental curricula, course design, and pedagogical strategies. A deep body of research suggests that one way we can promote inclusion is through the use of high impact practices (HIPs). These active learning teaching practices promote deep learning and student engagement and have been shown to have a positive differential impact on historically underserved student populations. Here we describe the characteristics of two different types of HIP courses, makerspace classes, and course-based undergraduate research experiences (CUREs). In addition, we provide ideas for how these courses can be structured to help all students engage and learn. With experience overseeing a large campus-wide program introducing these course types to the curriculum, we also provide insights about faculty experiences and assessment. We propose that including these types of courses in a curriculum can engage a more diverse group of students to choose neuroscience as a major and as a career

(2E)-1-(6-Chloro-2-methyl-4-phenyl­quinolin-3-yl)-3-phenyl­prop-2-en-1-one

In the title compound, C25H18ClNO, the conformation about the C=C double bond is E. Significant twists are evident in the mol­ecule, with the benzene ring forming a dihedral angle of 53.92 (11)° with the quinolinyl residue. Further, the chalcone residue is approximately perpendicular to the quinolinyl residue [Cq—Cq—Cc—Oc torsion angle = −104.5 (3)°, where q = quinolinyl and c = chalcone]. In the crystal, the presence of C—H⋯O and C—H⋯π inter­actions leads to supra­molecular layers lying parallel to (02)