Methods for local gravity field approximation

The most widely known modern method for estimating gravity field values from observed data is least-squares collocation. Its advantages are that it can make estimates at arbitrary locations based on irregularly spaced observations, and that it makes use of statistical information about errors in the input data while providing corresponding information about the quality of the output estimates. Disadvantages of collocation include the necessity of inverting square matrices of dimension equal to the number of data values and the need to assume covariance models for the gravity field and the data errors. Fourier methods are an important alternative to collocation; having the advantage of greater computational efficiency, but requiring data estimates to be on a regular grid and not using or providing statistical accuracy information. The GEOFAST algorithm is an implementation of collocation that achieves high computational efficiency by transforming the estimation equations into the frequency domain where an accurate approximation may be made to reduce the workload. The forward and inverse Fast Fourier Transforms (FFTs) are utilized. The accuracy and computational efficiency of the GEOFAST algorithm is demonstrated using two sets of synthetic gravity data: marine gravity for an ocean trench region including wavelengths longer than 200 km; and local land gravity containing wavelengths as short as 5 km. These results are discussed along with issues such as the advantages of first removing reference field models before carrying out the estimation algorithm

Autocatalytic plume pinch-off

A localized source of buoyancy flux in a non-reactive fluid medium creates a plume. The flux can be provided by either heat, a compositional difference between the fluid comprising the plume and its surroundings, or a combination of both. For autocatalytic plumes produced by the iodate-arsenous acid reaction, however, buoyancy is produced along the entire reacting interface between the plume and its surroundings. Buoyancy production at the moving interface drives fluid motion, which in turn generates flow that advects the reaction front. As a consequence of this interplay between fluid flow and chemical reaction, autocatalytic plumes exhibit a rich dynamics during their ascent through the reactant medium. One of the more interesting dynamical features is the production of an accelerating vortical plume head that in certain cases pinches-off and detaches from the upwelling conduit. After pinch-off, a new plume head forms in the conduit below, and this can lead to multiple generations of plume heads for a single plume initiation. We investigated the pinch-off process using both experimentation and simulation. Experiments were performed using various concentrations of glycerol, in which it was found that repeated pinch-off occurs exclusively in a specific concentration range. Autocatalytic plume simulations revealed that pinch-off is triggered by the appearance of accelerating flow in the plume conduit.Comment: 10 figures. Accepted for publication in Phys Rev E. See also http://www.physics.utoronto.ca/nonlinear/papers_chemwave.htm

Four Generations and Higgs Physics

In the light of the LHC, we revisit the implications of a fourth generation of chiral matter. We identify a specific ensemble of particle masses and mixings that are in agreement with all current experimental bounds as well as minimize the contributions to electroweak precision observables. Higgs masses between 115-315 (115-750) GeV are allowed by electroweak precision data at the 68% and 95% CL. Within this parameter space, there are dramatic effects on Higgs phenomenology: production rates are enhanced, weak-boson-fusion channels are suppressed, angular distributions are modified, and Higgs pairs can we observed. We also identify exotic signals, such as Higgs decay to same-sign dileptons. Finally, we estimate the upper bound on the cutoff scale from vacuum stability and triviality.Comment: 11 pages, 7 figures, REVTe

Elastic Scattering and Direct Detection of Kaluza-Klein Dark Matter

Recently a new dark matter candidate has been proposed as a consequence of universal compact extra dimensions. It was found that to account for cosmological observations, the masses of the first Kaluza-Klein modes (and thus the approximate size of the extra dimension) should be in the range 600-1200 GeV when the lightest Kaluza-Klein particle (LKP) corresponds to the hypercharge boson and in the range 1 - 1.8 TeV when it corresponds to a neutrino. In this article, we compute the elastic scattering cross sections between Kaluza-Klein dark matter and nuclei both when the lightest Kaluza-Klein particle is a KK mode of a weak gauge boson, and when it is a neutrino. We include nuclear form factor effects which are important to take into account due to the large LKP masses favored by estimates of the relic density. We present both differential and integrated rates for present and proposed Germanium, NaI and Xenon detectors. Observable rates at current detectors are typically less than one event per year, but the next generation of detectors can probe a significant fraction of the relevant parameter space.Comment: 23 pages, 11 figures; v2,v3: Ref. added, discussion improved, conclusions unchanged. v4: Introduction was expanded to be more appropriate for non experts. Various clarifications added in the text. Version to be published in New Journal of Physic

Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci

African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development. Trypanosoma brucei rhodesiense, which infects humans and livestock in East and Southern Africa, has classically been described as a host-range variant of the non-human infective Trypanosoma brucei that occurs as stable clonal lineages. We have examined T. b. rhodesiense populations from East (Uganda) and Southern (Malawi) Africa using a panel of microsatellite markers, incorporating both spatial and temporal analyses. Our data demonstrate that Ugandan T. b. rhodesiense existed as clonal populations, with a small number of highly related genotypes and substantial linkage disequilibrium between pairs of loci. However, these populations were not stable as the dominant genotypes changed and the genetic diversity also reduced over time. Thus these populations do not conform to one of the criteria for strict clonality, namely stability of predominant genotypes over time, and our results show that, in a period in the mid 1990s, the previously predominant genotypes were not detected but were replaced by a novel clonal population with limited genetic relationship to the original population present between 1970 and 1990. In contrast, the Malawi T. b. rhodesiense population demonstrated significantly greater diversity and evidence for frequent genetic exchange. Therefore, the population genetics of T. b. rhodesiense is more complex than previously described. This has important implications for the spread of the single copy T. b. rhodesiense gene that allows human infectivity, and therefore the epidemiology of the human disease, as well as suggesting that these parasites represent an important organism to study the influence of optional recombination upon population genetic dynamics

Key worker services for disabled children: what characteristics of services lead to better outcomes for children and families?

Background: Research has shown that families of disabled children who have a key worker benefit from this service and recent policy initiatives emphasize the importance of such services. However, research is lacking on which characteristics of key worker schemes for disabled children are related to better outcomes for families. Methods: A postal questionnaire was completed by 189 parents with disabled children who were receiving a service in seven key worker schemes in England and Wales. Path analysis was used to investigate associations between characteristics of the services and outcomes for families (satisfaction with the service, impact of key worker on quality of life, parent unmet need, child unmet need). Results: The four path models showed that key workers carrying out more aspects of the key worker role, appropriate amounts of contact with key workers, regular training, supervision and peer support for key workers, and having a dedicated service manager and a clear job description for key workers were associated with better outcomes for families. Characteristics of services had only a small impact on child unmet need, suggesting that other aspects of services were affecting child unmet need. Conclusions: Implications for policy and practice are discussed, including the need for regular training, supervision and peer support for key workers and negotiated time and resources for them to carry out the role. These influence the extent to which key workers carry out all aspects of the key worker's role and their amount of contact with families, which in turn impact on outcomes

Discovery of mating in the major African livestock pathogen Trypanosoma congolense

The protozoan parasite, Trypanosoma congolense, is one of the most economically important pathogens of livestock in Africa and, through its impact on cattle health and productivity, has a significant effect on human health and well being. Despite the importance of this parasite our knowledge of some of the fundamental biological processes is limited. For example, it is unknown whether mating takes place. In this paper we have taken a population genetics based approach to address this question. The availability of genome sequence of the parasite allowed us to identify polymorphic microsatellite markers, which were used to genotype T. congolense isolates from livestock in a discrete geographical area of The Gambia. The data showed a high level of diversity with a large number of distinct genotypes, but a deficit in heterozygotes. Further analysis identified cryptic genetic subdivision into four sub-populations. In one of these, parasite genotypic diversity could only be explained by the occurrence of frequent mating in T. congolense. These data are completely inconsistent with previous suggestions that the parasite expands asexually in the absence of mating. The discovery of mating in this species of trypanosome has significant consequences for the spread of critical traits, such as drug resistance, as well as for fundamental aspects of the biology and epidemiology of this neglected but economically important pathogen