Photophoretic Structuring of Circumstellar Dust Disks

We study dust accumulation by photophoresis in optically thin gas disks. Using formulae of the photophoretic force that are applicable for the free molecular regime and for the slip-flow regime, we calculate dust accumulation distances as a function of the particle size. It is found that photophoresis pushes particles (smaller than 10 cm) outward. For a Sun-like star, these particles are transported to 0.1-100 AU, depending on the particle size, and forms an inner disk. Radiation pressure pushes out small particles (< 1 mm) further and forms an extended outer disk. Consequently, an inner hole opens inside ~0.1 AU. The radius of the inner hole is determined by the condition that the mean free path of the gas molecules equals the maximum size of the particles that photophoresis effectively works on (100 micron - 10 cm, depending on the dust property). The dust disk structure formed by photophoresis can be distinguished from the structure of gas-free dust disk models, because the particle sizes of the outer disks are larger, and the inner hole radius depends on the gas density.Comment: 15 pages, 9 figures, Accepted by ApJ; corrected a typo in the author nam

A Potent CD1d-binding Glycolipid for iNKT-Cell-based Therapy Against Human Breast Cancer

Background/Aim: Invariant natural killer T-cells (iNKT) stimulated by CD1d-binding glycolipids have been shown to exert antitumor effects by a number of studies in a mouse model. Breast cancer is a devastating disease, with different types of breast cancer recurring locally or distant as metastatic/advanced disease following initial treatment. The aim of this study was to examine the tumoricidal effect of a CD1d-binding glycolipid, called 7DW8-5, against a highly invasive human breast cancer cell line both in vitro and in vivo. Materials and Methods: Parental MDA-MB-231 cells and MDA-MB-231 cells transduced with human CD1d were labeled with carboxyfluorescein diacetate succinimidyl ester (CFSE), followed by loading with glycolipids. After co-culturing with human iNKT cells, the cells were permeabilized and stained with Alexa Flour 647-conjugated antibody to active caspase-3, and analyzed using a BD LSR II. For the in vivo tumoricidal effect, MDA-MB-231 cells transduced with human CD1d and luciferase genes were injected into the mammary fat pad of female NOD/SCID/IL2rγnull (NSG) mice, followed by the injection of human iNKT cells with or without 7DW8-5, and the levels of luminescence were analyzed with whole-body imaging. Results: Human iNKT cells could kill CD1d-expressing human breast cancer cells in vitro in the presence of 7DW8-5, but not α-GalCer. As for in vivo, the adoptive transfer of human iNKT cells into tumor-challenged NSG mice significantly inhibited the growth of CD1d+ MDA-MB-231 human breast cancer cells in the presence of 7DW8-5. Conclusion: CD1d-binding, glycolipid-based iNKT-cell therapy is suggested as a potent and effective treatment against breast cancer in humans

Chemical Equilibrium Abundances in Brown Dwarf and Extrasolar Giant Planet Atmospheres

We calculate detailed chemical abundance profiles for a variety of brown dwarf and extrasolar giant planet atmosphere models, focusing in particular on Gliese 229B, and derive the systematics of the changes in the dominant reservoirs of the major elements with altitude and temperature. We assume an Anders and Grevesse (1989) solar composition of 27 chemical elements and track 330 gas--phase species, including the monatomic forms of the elements, as well as about 120 condensates. We address the issue of the formation and composition of clouds in the cool atmospheres of substellar objects and explore the rain out and depletion of refractories. We conclude that the opacity of clouds of low--temperature ($\le$900 K), small--radius condensibles (specific chlorides and sulfides), may be responsible for the steep spectrum of Gliese 229B observed in the near infrared below 1 \mic. Furthermore, we assemble a temperature sequence of chemical transitions in substellar atmospheres that may be used to anchor and define a sequence of spectral types for substellar objects with T$_{eff}$s from $\sim$2200 K to $\sim$100 K.Comment: 57 pages total, LaTeX, 14 figures, 5 tables, also available in uuencoded, gzipped, and tarred form via anonymous ftp at www.astrophysics.arizona.edu (cd to pub/burrows/chem), submitted to Ap.

Dust in the Photospheric Environment: Unified Cloudy Models of M, L, and T Dwarfs

We address the problem of how dust forms and how it could be sustained in the static photospheres of cool dwarfs for a long time. In the cool and dense gas, dust forms easily at the condensation temperature, T_cond, and the dust can be in detailed balance with the ambient gas so long as it remains smaller than the critical radius, r_cr. However, dust will grow larger and segregate from the gas when it will be larger than r_cr somewhere at the lower temperature, which we refer to as the critical temperature, T_cr. Then, the large dust grains will precipitate below the photosphere and only the small dust grains in the region of T_cr < T < T_cond can be sustained in the photosphere. Thus a dust cloud is formed. Incorporating the dust cloud, non-grey model photo- spheres in radiative-convective equilibrium are extended to T_eff as low as 800K. Observed colors and spectra of cool dwarfs can consistently be accounted for by a single grid of our cloudy models. This fact in turn can be regarded as supporting evidence for our basic assumption on the cloud formation.Comment: 50 pages with 14 postscript figures, to be published in Astrophys.

The Theorem of Jentzsch--Szeg\H{o} on an analytic curve. Application to the irreducibility of truncations of power series

The theorem of Jentzsch--Szeg\H{o} describes the limit measure of a sequence of discrete measures associated to the zeroes of a sequence of polynomials in one variable. Following the presentation of this result by Andrievskii and Blatt in their book, we extend this theorem to compact Riemann surfaces, then to analytic curves over an ultrametric field. The particular case of the projective line over an ultrametric field gives as corollaries information about the irreducibility of the truncations of a power series in one variable.Comment: 16 pages; the application to irreducibility and the final example have been correcte

Large orbital magnetic moments in carbon nanotubes generated by resonant transport

The nonequilibrium Green's function method is used to study the ballistic transport in metallic carbon nanotubes when a current is injected from the electrodes with finite bias voltages. We reveal, both analytically and numerically, that large loop currents circulating around the tube are induced, which come from a quantum mechanical interference and are much larger than the current along the tube axis when the injected electron is resonant with a time-reversed pair of degenerate states, which are, in fact, inherent in the zigzag and chiral nanotubes. This results in large orbital magnetic moments, making the nanotube a molecular solenoid.Comment: 5 pages, 4 figures; typos correcte

The Spectrum of the Brown Dwarf Gliese 229B

We present a spectrum of the cool (T_eff = 900 K) brown dwarf Gliese 229B. This spectrum, with a relatively high signal-to-noise ratio per spectral resolution element (> 30), spans the wavelength range from 0.837 microns to 5.0 microns. We identify a total of four different major methane absorption features, including the fundamental band at 3.3 microns, at least four steam bands, and two neutral cesium features. We confirm the recent detection of carbon monoxide (CO) in excess of what is predicted by thermochemical equilibrium calculations. Carbon is primarily involved in a chemical balance between methane and CO at the temperatures and pressures present in the outer parts of a brown dwarf. At lower temperatures, the balance favors methane, while in the deeper, hotter regions, the reaction reverses to convert methane into CO. The presence of CO in the observable part of the atmosphere is therefore a sensitive indicator of vertical flows. The high signal-to-noise ratio in the 1 to 2.5 microns region permits us to place constraints on the quantity of dust in the atmosphere of the brown dwarf. We are unable to reconcile the observed spectrum with synthetic spectra that include the presences of dust. The presence of CO but lack of dust may be a clue to the location of the boundaries of the outer convective region of the atmosphere: The lack of dust may mean that it is not being conveyed into the photosphere by convection, or that it exists in patchy clouds. If the dust is not in clouds, but rather sits below the outer convective region, we estimate that the boundary between outer convective and inner radiative layers is between 1250 K and 1600 K, in agreement with recent models.Comment: 15 pages, 8 figure

Extrasolar Giant Planets under Strong Stellar Irradiation

We investigate the effects on extrasolar giant planets [EGPs] of intense irradiation by their parent stars, describing the issues involved in treating the model atmosphere problem correctly. We treat the radiative transfer in detail, allowing the flux from the parent star to interact with all relevant depths of the planetary atmosphere, with no need for a pre-assumed albedo. We present a low-resolution optical and near-IR spectrum of a close-in EGP, focusing on the differences from an isolated planet. In our dust-free planetary atmospheres we find that Rayleigh scattering increases the EGP's flux by orders of magnitude shortward of the CaII H&K doublet (393 nm), and the spectral features of the parent star are exactly reflected. In the optical and near-IR the thermal absorption of the planet takes over, but the absorption features are changed by the irradiation. The inclusion of dust increases the reflected flux in the blue; the stellar spectral lines can be seen blueward of H-beta (486 nm).Comment: 14 pages, 4 figures, LaTex, accepted in ApJ