Gradual wavelet reconstruction of the velocity increments for turbulent wakes

This work explores the properties of the velocity increment distributions for wakes of contrasting local Reynolds number and nature of generation (a cylinder wake and a multiscale-forced case, respectively). It makes use of a technique called gradual wavelet reconstruction (GWR) to generate constrained randomizations of the original data, the nature of which is a function of a parameter, ϑ. This controls the proportion of the energy between the Markov-Einstein length (∼ 0.8 Taylor scales) and integral scale that is fixed in place in the synthetic data. The properties of the increments for these synthetic data are then compared to the original data as a function of ϑ. We write a Fokker-Planck equation for the evolution of the velocity increments as a function of spatial scale, r, and, in line with previous work, expand the drift and diffusion terms in terms up to fourth order in the increments and find no terms are relevant beyond the quadratic terms. Only the linear contribution to the expansion of the drift coefficient is non-zero and it exhibits a consistent scaling with ϑ for different flows above a low threshold. For the diffusion coefficient, we find a local Reynolds number independence in the relation between the constant term and ϑ for the multiscale-forced wakes. This term characterizes small scale structure and can be contrasted with the results for the Kolmogorov capacity of the zero-crossings of the velocity signals, which measures structure over all scales and clearly distinguishes between the types of forcing. Using GWR shows that results for the linear and quadratic terms in the expansion of the diffusion coefficient are significant, providing a new means for identifying intermittency and anomalous scaling in turbulence datasets. All our data showed a similar scaling behavior for these parameters irrespective of forcing type or Reynolds number, indicating a degree of universality to the anomalous scaling of turbulence. Hence, these terms are a useful metric for testing the efficacy of synthetic turbulence generation schemes used in large eddy simulation, and we also discuss the implications of our approach for reduced order modeling of the Navier-Stokes equations

The coupling between inner and outer scales in a zero pressure boundary layer evaluated using a Hölder exponent framework

This work considers the connectivity between large and small scales in boundary-layer turbulence by formalizing the modulation effect of the small scales by the large in terms of the pointwise Hölder condition for the small scales. We re-investigate a previously published dataset from this perspective and are able to characterize the coupling effectively using the (cross-)correlative relations between the large scale velocity and the small scale Hölder exponents. The nature of this coupling varies as a function of dimensionless distance from the wall based on inner-scaling, ${y}^{+}$, as well as on the boundary-layer height, δ. In terms of the fundamental change in the sign of the coupling between large and small scales, the critical height appears to be ${y}^{+}\sim 1000$. Below this height, small scale structures are associated with (and occur earlier than) maxima in the large scale velocity. Above this height, while the lag is similar in magnitude, the small scale structures are associated with minima in the large scale velocity. To consider these results further, we introduce a modified quadrant analysis and show that it is the coupling to the large scale low velocity state that is critical for the dynamics

Identification of Specific Language Impairment in Multilingual Contexts: Preliminary Validation of a Short Parental Bilingual Questionnaire in Lebanon

Assessing children with Specific language Impairment (SLI) in multilingual contexts is challenging for speech language therapists given that language patterns in bilinguals and in children with SLI are often reported to be remarkably similar and that screening language tests are not standardized on bilingual populations. The present study aims to validate the use of a parental questionnaire focusing on early language development, the languages spoken by the child, the use of languages in his/her environment, and information on linguistic difficulties within the family, as a complement to language assessment in multilingual contexts. Thirty-three Lebanese/French bilingual children (12 with SLI and 21 with typical development) and their parents participated in this study in Lebanon. The parents were interviewed via the questionnaire while the children were administered standardized language tests in each language. Data analysis showed that the parents’ answers to the questionnaire were coherent throughout and that some variables of the questionnaire strongly discriminated between the two groups of children, in particular the age of the first words and first sentences. Moreover, although significant correlations were found with language test scores, the answers to the questionnaire allowed us to refine the interpretation of the performance on the standardized tests, thus demonstrating the value of the parental questionnaire as a complementary tool to clinical evaluation

Cancer Treatment Dosing Regimens of Zoledronic Acid Result in Near-Complete Suppression of Mandible Intracortical Bone Remodeling in Beagle Dogs

Bisphosphonate doses used in cancer treatment are substantially higher than those used for osteoporosis. Little is known about the effects of these high doses on tissue-level remodeling suppression. The aim of this study was to assess the effects of cancer dosing regimens of zoledronic acid on tissue-level bone remodeling at different skeletal sites. Skeletally mature female beagle dogs were treated with monthly intravenous infusions of vehicle (VEH, saline) or zoledronic acid (ZOL, 0.067 mg/kg); an additional group of animals was treated daily with oral alendronate (ALN, 0.2 mg/kg/day). Doses of ZOL and ALN were, on a milligram per kilogram basis, consistent with those used for cancer and osteoporosis, respectively. Following either 3 or 6 months of treatment, animals were euthanized, and mandible, rib, and tibia were processed for dynamic bone histology. There was no evidence of oral lesions or bone matrix necrosis in the mandibles of any animals. After 3 months, the rate of intracortical bone remodeling in the mandible was significantly suppressed with ZOL (−95%) compared with VEH; by 6 months, ZOL had produced nearly complete suppression (−99%) compared with VEH. ZOL also significantly suppressed remodeling in the rib cortex at both 3 (−83%) and 6 (−85%) months compared with VEH; tibia cortex bone formation rate was nonsignificantly lower with ZOL treatment (−68% to −75%). Remodeling suppression in ZOL-treated animals was significantly greater than in ALN-treated animals at both the mandible and the rib; ALN and VEH were not different for any of the assessed parameters at any of the sites. Compared across skeletal sites, the absolute level of remodeling suppression with ZOL treatment was significantly greater at sites with higher remodeling, whereas the percent reduction was similar among the sites. These results document nearly complete intracortical remodeling suppression resulting from monthly intravenous zoledronic acid dosing, with changes being most dramatic at the mandible. Copyright © 2010 American Society for Bone and Mineral Researc

Tumour macrophages as potential targets of bisphosphonates

Tumour cells communicate with the cells of their microenvironment via a series of molecular and cellular interactions to aid their progression to a malignant state and ultimately their metastatic spread. Of the cells in the microenvironment with a key role in cancer development, tumour associated macrophages (TAMs) are among the most notable. Tumour cells release a range of chemokines, cytokines and growth factors to attract macrophages, and these in turn release numerous factors (e.g. VEGF, MMP-9 and EGF) that are implicated in invasion-promoting processes such as tumour cell growth, flicking of the angiogenic switch and immunosuppression. TAM density has been shown to correlate with poor prognosis in breast cancer, suggesting that these cells may represent a potential therapeutic target. However, there are currently no agents that specifically target TAM's available for clinical use

Cointegration of output, capital, labor, and energy

89.65.Gh Economics; econophysics, financial markets, business and management, 05.45.Tp Time series analysis,