1,194 research outputs found
Magnon contribution to unidirectional spin Hall magnetoresistance
We develop a model for the magnonic contribution to the unidirectional spin
Hall magnetoresistance (USMR) of heavy metal/ferromagnetic insulator bilayer
films. We show that diffusive transport of Holstein-Primakoff magnons leads to
an accumulation of spin near the bilayer interface, giving rise to a
magnoresistance which is not invariant under inversion of the current
direction. Unlike the electronic contribution described by Zhang and Vignale
[Phys. Rev. B 94, 140411 (2016)], which requires an electrically conductive
ferromagnet, the magnonic contribution can occur in ferromagnetic insulators
such as yttrium iron garnet. We show that the magnonic USMR is, to leading
order, cubic in the spin Hall angle of the heavy metal, as opposed to the
linear relation found for the electronic contribution. We estimate that the
maximal magnonic USMR in Pt|YIG bilayers is on the order of , but may
reach values of up to if the magnon gap is suppressed, and can thus
become comparable to the electronic contribution in, e.g., Pt|Co. We show that
the magnonic USMR at a finite magnon gap may be enhanced by an order of
magnitude if the magnon diffusion length is decreased to a specific optimal
value that depends on various system parameters.Comment: 9 pages, 7 figure
EUV and X-ray spectroheliograph study
The results of a program directed toward the definition of an EUV and X-ray spectroheliograph which has significant performance and operational improvements over the OSO-7 instrument are documented. The program investigated methods of implementing selected changes and incorporated the results of the study into a set of drawings which defines the new instrument. The EUV detector performance degradation observed during the OSO-7 mission was investigated and the most probable cause of the degradation identified
Особенности учета расходов и доходов, и их влияние на финансовый результат деятельности субъекта хозяйствования
Основная цель статьи - раскрыть специфику отражения на счетах бухгалтерского учета расходов, доходов и определить их влияние на формирование финансового результата от операционной, финансовой или инвестиционной деятельности.Основна мета статті - розкрити специфіку віддзеркалення на рахунках бухгалтерського обліку витрат, доходів і визначити їх вплив на формування фінансового результату від операційної, фінансової або інвестиційної діяльності
Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study
Background Asthma exacerbations are frequently triggered by rhinovirus infections. Both asthma and respiratory tract infection can activate haemostasis. Therefore we hypothesized that experimental rhinovirus-16 infection and asthmatic airway inflammation act in synergy on the haemostatic balance. Methods 28 patients (14 patients with mild allergic asthma and 14 healthy non-allergic controls) were infected with low-dose rhinovirus type 16. Venous plasma and bronchoalveolar lavage fluid (BAL fluid) were obtained before and 6 days after infection to evaluate markers of coagulation activation, thrombin-antithrombin complexes, von Willebrand factor, plasmin-antiplasmin complexes, plasminogen activator inhibitor type-1, endogenous thrombin potential and tissue factor-exposing microparticles by fibrin generation test, in plasma and/or BAL fluid. Data were analysed by nonparametric tests (Wilcoxon, Mann Whitney and Spearman correlation). Results 13 patients with mild asthma (6 females, 19-29 y) and 11 healthy controls (10 females, 19-31 y) had a documented Rhinovirus-16 infection. Rhinovirus-16 challenge resulted in a shortening of the fibrin generation test in BAL fluid of asthma patients (t = -1: 706 s vs. t = 6: 498 s; p = 0.02), but not of controls (t = -1: 693 s vs. t = 6: 636 s; p = 0.65). The fold change in tissue factor-exposing microparticles in BAL fluid inversely correlated with the fold changes in eosinophil cationic protein and myeloperoxidase in BAL fluid after virus infection (r = -0.517 and -0.528 resp., both p = 0.01). Rhinovirus-16 challenge led to increased plasminogen activator inhibitor type-1 levels in plasma in patients with asthma (26.0 ng/mL vs. 11.5 ng/mL in healthy controls, p = 0.04). Rhinovirus-16 load in BAL showed a linear correlation with the fold change in endogenous thrombin potential, plasmin-antiplasmin complexes and plasminogen activator inhibitor type-1. Conclusions Experimental rhinovirus infection induces procoagulant changes in the airways of patients with asthma through increased activity of tissue factor-exposing microparticles. These microparticle-associated procoagulant changes are associated with both neutrophilic and eosinophilic inflammation. Systemic activation of haemostasis increases with Rhinoviral load
4.10 A review of available bumble bee colony end-points and identification of current knowledge gaps
Sex hormone-binding globulin regulation of androgen bioactivity in vivo : validation of the free hormone hypothesis
Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues. Still, the in vivo physiological role of circulating SHBG remains unclear, especially since mice and rats lack circulating SHBG post-natally. To test the free hormone hypothesis in vivo, we examined total and free sex steroid concentrations and bioactivity on target organs in mice expressing a human SHBG transgene. SHBG increased total androgen and estrogen concentrations via hypothalamic-pituitary feedback regulation and prolonged ligand half-life. Despite markedly raised total sex steroid concentrations, free testosterone was unaffected while sex steroid bioactivity on male and female reproductive organs was attenuated. This occurred via a liganddependent, genotype-independent mechanism according to in vitro seminal vesicle organ cultures. These results provide compelling support for the determination of free or bioavailable sex steroid concentrations in medicine, and clarify important comparative differences between translational mouse models and human endocrinology
Will HIV Vaccination Reshape HIV Risk Behavior Networks? A Social Network Analysis of Drug Users\u27 Anticipated Risk Compensation
Background
An HIV vaccine could substantially impact the epidemic. However, risk compensation (RC), or post-vaccination increase in risk behavior, could present a major challenge. The methodology used in previous studies of risk compensation has been almost exclusively individual-level in focus, and has not explored how increased risk behavior could affect the connectivity of risk networks. This study examined the impact of anticipated HIV vaccine-related RC on the structure of high-risk drug users\u27 sexual and injection risk network.
Methods
A sample of 433 rural drug users in the US provided data on their risk relationships (i.e., those involving recent unprotected sex and/or injection equipment sharing). Dyad-specific data were collected on likelihood of increasing/initiating risk behavior if they, their partner, or they and their partner received an HIV vaccine. Using these data and social network analysis, a post-vaccination network was constructed and compared to the current network on measures relevant to HIV transmission, including network size, cohesiveness (e.g., diameter, component structure, density), and centrality.
Results
Participants reported 488 risk relationships. Few reported an intention to decrease condom use or increase equipment sharing (4% and 1%, respectively). RC intent was reported in 30 existing risk relationships and vaccination was anticipated to elicit the formation of five new relationships. RC resulted in a 5% increase in risk network size (n = 142 to n = 149) and a significant increase in network density. The initiation of risk relationships resulted in the connection of otherwise disconnected network components, with the largest doubling in size from five to ten.
Conclusions
This study demonstrates a new methodological approach to studying RC and reveals that behavior change following HIV vaccination could potentially impact risk network connectivity. These data will be valuable in parameterizing future network models that can determine if network-level change precipitated by RC would appreciably impact the vaccine\u27s population-level effectiveness
The Geometry and Moduli of K3 Surfaces
These notes will give an introduction to the theory of K3 surfaces. We begin
with some general results on K3 surfaces, including the construction of their
moduli space and some of its properties. We then move on to focus on the theory
of polarized K3 surfaces, studying their moduli, degenerations and the
compactification problem. This theory is then further enhanced to a discussion
of lattice polarized K3 surfaces, which provide a rich source of explicit
examples, including a large class of lattice polarizations coming from elliptic
fibrations. Finally, we conclude by discussing the ample and Kahler cones of K3
surfaces, and give some of their applications.Comment: 34 pages, 2 figures. (R. Laza, M. Schutt and N. Yui, eds.
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