284 research outputs found

    Transparency effect in the emergence of monopolies in social networks

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    Power law degree distribution was shown in many complex networks. However, in most real systems, deviation from power-law behavior is observed in social and economical networks and emergence of giant hubs is obvious in real network structures far from the tail of power law. We propose a model based on the information transparency (transparency means how much the information is obvious to others). This model can explain power structure in societies with non-transparency in information delivery. The emergence of ultra powerful nodes is explained as a direct result of censorship. Based on these assumptions, we define four distinct transparency regions: perfect non-transparent, low transparent, perfect transparent and exaggerated regions. We observe the emergence of some ultra powerful (very high degree) nodes in low transparent networks, in accordance with the economical and social systems. We show that the low transparent networks are more vulnerable to attacks and the controllability of low transparent networks is harder than the others. Also, the ultra powerful nodes in the low transparent networks have a smaller mean length and higher clustering coefficients than the other regions.Comment: 14 Pages, 3 figure

    Adverse Drug Reaction Monitoring of Anticancer Drugs in Hematology Department

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    Background: Cancer is among the leading causes of mortality in India. Studies have reported antineoplastic agents as the common class of drugs causing Adverse Drug Reactions (ADRs). The present study aimed to conduct active surveillance of ADRs of anticancer drugs in the hematology department.Methods: A prospective observational study was conducted in 136 patients with cancer and the incidence and frequency of ADRs were assessed. The study was conducted in 6 months in a multispecialty hospital.Results: Among 136 cancer patients, All was more prevalent (39.70%); CLL, Non- Hodgkin’s Lymphoma were less prevalent (0.73%). ADRs were more prevalent in the Pediatrics department, i.e., 18.53% of ADRs were observed in patients aged <10 years. ADRs in male patients constituted 54.39%, whereas it was 45.60% in female patients. Cytarabine caused the highest number of ADRs (34.48%). The most prevalent ADR was anemia (25.60%).Conclusion: Multiple ADRs were detected in cancer patients. We found that hematological ADRs were more prevalent. Most of the ADRs were possible reactions according to Naranjo and the World Health Organization (WHO) scales

    Use of some isolated fungi in biological Leaching of Aluminum from low grade bauxite

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    In this investigation the biological leaching of aluminum by isolated fungi from low grade bauxite

    Effect of pioglitazone therapy on high sensitive C-reactive protein and lipid profile in diabetic patients with renal transplantation; a randomize clinical trial

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    Background: Inflammation has a major role in disease lead to renal failure and diabetes mellitus, controlling inflammation in diabetic kidney receivers could decrease morbidity and mortality. Objectives: This study designed for evaluating the efficacy of pioglitazone on C-reactive protein and lipid profile in diabetic kidney transplant receivers. Patients and Methods: In this double blinded clinical trial, 58 diabetic renal transplant receivers, in first month after transplantation, randomized into two groups; receiving insulin and pioglitazone (15 mg tablet daily, group A); and insulin and placebo (group B). Blood pressure, weight, body mass index (BMI) and laboratory data compared in before and after 4-month treatment in two groups by SPSS. Results: Fifty-eight patients with mean age of 44.15 ± 2 years included. There were no significant difference between groups in demographic data and other baseline measured variables (P > 0.05).The mean weigh and BMI were slightly increased in group A and decreased in group B. The mean hs-CRP was decreased 4.82 mg/dL in group A and 1.93 mg/dL in group B (P = 0.007). The mean total serum cholesterol was significantly decreased 34 mg/dL in group A and 18.07 mg/dL in group B (P = 0.027). The mean serum HDL-C was significantly increased 13.31 mg/dL in group A and 5.89 mg/dl in group B (P < 0.001). Conclusions: Pioglitazone seems to be a safe drug for reducing serum lipids and CRP in kidney transplant receivers with diabetes mellitus in short term. Long term effect of this drug could be evaluated in future studies. Copyright © 2015 The Author(s)

    Age structure and growth rate of (Squalius cephalus Linnaeus, 1758) in Tuji tributary from Talar River, Mazandaran Province

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    A structure and growth pattern of Squalius cephalus (Linnaeus, 1758) in Tuji tributary of Talar River, Mazandaran Province, was studied during the period from August 2008 till August 2009. In total, 298 fish were caught by electrofishing and fixed in 10% formalin. The weight and length of fish were measured and the age was determinated by scallometric method. The age data showed that fishes were between 0+ to 4+ age groups. Pauli`s applied growth pattern showed a positive alometric for male and female and total fish and a negative isometric for unmature fishes. The average instantaneous growth rate of European Chub showed that the age groups 2+ and 3+ with 1.1 had the fastest growth compare to 3+ and 4+ age groups with 0.89. Condition factor of specimens showed that the highest one with 1.58 (r2 = 0.983) belong to females and the lowest with 1.17 (r2 = 0.901) belong to unmature fishes. The total sex ratio (123 males to 115 females) showed no significant differences between them

    Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure

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    Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. The majority of women with this disorder develop POI, however rare spontaneous pregnancies have been reported. Here, we evaluate the effect of D-galactose and its metabolites, galactitol and galactose 1-phosphate, on oocyte quality as well as embryo development to elucidate the mechanism through which these compounds mediate oocyte deterioration. Metaphase II mouse oocytes (n=240), with and without cumulus cells (CCs), were exposed for 4hours to D-galactose (2μM), galactitol (11μM) and galactose 1-phosphate (0.1mM), (corresponding to plasma concentrations in patients on galactoserestricted diet) and compared to controls. The treated oocytes showed decreased quality as a function of significant enhancement in production of reactive oxygen species (ROS) when compared to controls. The presence of CCs offered no protection, as elevated ROS was accompanied by increased apoptosis of CCs. Our results suggested that D-galactose and its metabolites disturbed the spindle structure and chromosomal alignment, which was associated with significant decline in oocyte cleavage and blastocyst development after in-vitro fertilization. The results provide insight into prevention and treatment strategies that may be used to extend the window of fertility in these patients

    Comparison of the efficacy of NeoNiTi, ProTaper, and Reciproc files in the retreatment of curved root canals: a CBCT assessment

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    Objective: Effective tools and methods are applied during root canal retreatment to eliminate root canal obturation materials and preserve the initial root canal anatomy. The present study compared the efficacy of Reciproc, Neoniti, ProTaper, and Hedstrom files in the retreatment of curved root canals. Material and methods: In the present in vitro study, 100 root canals with 25‒45ºcurvatures were used. After the samples were initially prepared and examined by CBCT, the root canals were obturated with gutta-percha and randomly assigned to four groups (n=25). A retreatment was carried out in each group with NeoNiTi, ProTaper, Reciproc, and Hedstrom files. CBCT examinations were carried out again under the same conditions. The samples were evaluated at 3-, 6-, and 9-mm distances from the apex on the first and the second CBCT image for root canal transportation and remaining gutta-percha in the root canals. The time required for retreating each canal in each sample was recorded. One-way ANOVA and corresponding non-parametric tests were applied for data analysis. Results: The root canal transportation in the NeoNiTi group was lower than that in the other groups and significantly different from the ProTaper group (P&lt;0.05). There was a remaining gutta-percha after re-treatments in all the four groups, which was not statistically significant (P&gt;0.05). Conclusion: Despite the fact that the NeoNiTi file produced less transportation than other file systems evaluated in the retreatment of curved root canals, all the files were very effective at the clinically acceptable levels

    LNCS

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    We address the problem of analyzing the reachable set of a polynomial nonlinear continuous system by over-approximating the flowpipe of its dynamics. The common approach to tackle this problem is to perform a numerical integration over a given time horizon based on Taylor expansion and interval arithmetic. However, this method results to be very conservative when there is a large difference in speed between trajectories as time progresses. In this paper, we propose to use combinations of barrier functions, which we call piecewise barrier tube (PBT), to over-approximate flowpipe. The basic idea of PBT is that for each segment of a flowpipe, a coarse box which is big enough to contain the segment is constructed using sampled simulation and then in the box we compute by linear programming a set of barrier functions (called barrier tube or BT for short) which work together to form a tube surrounding the flowpipe. The benefit of using PBT is that (1) BT is independent of time and hence can avoid being stretched and deformed by time; and (2) a small number of BTs can form a tight over-approximation for the flowpipe, which means that the computation required to decide whether the BTs intersect the unsafe set can be reduced significantly. We implemented a prototype called PBTS in C++. Experiments on some benchmark systems show that our approach is effective

    LNCS

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    Imprecision in timing can sometimes be beneficial: Metric interval temporal logic (MITL), disabling the expression of punctuality constraints, was shown to translate to timed automata, yielding an elementary decision procedure. We show how this principle extends to other forms of dense-time specification using regular expressions. By providing a clean, automaton-based formal framework for non-punctual languages, we are able to recover and extend several results in timed systems. Metric interval regular expressions (MIRE) are introduced, providing regular expressions with non-singular duration constraints. We obtain that MIRE are expressively complete relative to a class of one-clock timed automata, which can be determinized using additional clocks. Metric interval dynamic logic (MIDL) is then defined using MIRE as temporal modalities. We show that MIDL generalizes known extensions of MITL, while translating to timed automata at comparable cost

    Study of parasites occurrence and intensity in fishes of Anzali Lagoon

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    Tish survey prolonged from summer 2011 trough summer 2012. During this period 574 samples of different fish species were investigated for their parasites. Totally 30 species of parasites isolated of the fishes. Some of the isolated parasites are recorded for the first time in Iran. Rafidascaris acus Orientocreadium siluri, Silurotaenia siluri, Acanthocephalus lucii , Argulus foliaceus has recorded for the first time from European catfish, Silurus glanis, and Dactylogyrus inexpectatus has recorded for the first time from Gibel Carp, Carassius auratus gibelio, in Anzali wetland. Statistical comparison of parasites infections and intensity between the different area of Anzali wetland were done. Infection of Pike, Esox lucius, to Diplostomum spathaceum, Raphidascaris acus and Monogenean in western parts of wetland were significantly different from the Eastern and Central areas (p<0.05). So based on the data have concluded the eastern and central regions of the wetland are more polluted than the western part. Comparing the results of the present study with before ones showed that the composition of parasite species has been changed over time, while the prevalence, intensity and abundance of parasites have been increased. It may be due to changing environmental conditions such as increasing discharge of effluent, eutrophication of the wetland. This results accents to necessity of reconstruction of Anzali wetland with preference of eastern and central regions
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