The artistic use of parallax and lenses revealing the invisible in holography

There are many artistic resources offered by holography: third-dimension registration and reconstruction, immateriality, color interpretation, holographic space, realism, etc. But there are a few of them which are very characteristic and singular of that media such as the inversion of parallax, and the possibility of making invisible to turn into visible. Current paper aims to discuss key issues concerning with the aesthetic use of those special features. It is based on theoretical as well as critical analysis of the production by some of the most outstanding holographic artists who have made use of such interesting resources

Capturing coevolutionary signals in repeat proteins

The analysis of correlations of amino acid occurrences in globular proteins has led to the development of statistical tools that can identify native contacts -- portions of the chains that come to close distance in folded structural ensembles. Here we introduce a statistical coupling analysis for repeat proteins -- natural systems for which the identification of domains remains challenging. We show that the inherent translational symmetry of repeat protein sequences introduces a strong bias in the pair correlations at precisely the length scale of the repeat-unit. Equalizing for this bias reveals true co-evolutionary signals from which local native-contacts can be identified. Importantly, parameter values obtained for all other interactions are not significantly affected by the equalization. We quantify the robustness of the procedure and assign confidence levels to the interactions, identifying the minimum number of sequences needed to extract evolutionary information in several repeat protein families. The overall procedure can be used to reconstruct the interactions at long distances, identifying the characteristics of the strongest couplings in each family, and can be applied to any system that appears translationally symmetric

Diagnóstico temprano del síndrome de Dravet: aportaciones de la clínica y la biología molecular

Alterations in SCN1A gene cause most cases of Dravet syndrome. This finding has increased scientific interest in the syndrome, helping to better define its clinical features and facilitating treatment. AIMS: To update the knowledge on Dravet syndrome and to discuss the role of the molecular studies in improving early detection and specific management of the syndrome. DEVELOPMENT: We review the current information on the causes, clinical and electrical characteristics, treatment and complications of Dravet syndrome. Special emphasis is made on early detection. CONCLUSIONS: The phenotype of Dravet syndrome is now better defined and early detection is already possible. As a consequence, it is now possible to use more specific antiepileptic drugs and to avoid harmful treatments. The benefits of better and prompter control of seizures and earlier cognitive interventions need to be demonstrated in prospective studies of children diagnosed in their first year of life

Variabilidad de la evolución cognitiva en los distintos tipos de epilepsia del niño

Children with epilepsy have a higher risk of suffering from cognitive and behavioural disorders, the intensity and repercussions of which may be more or less important. AIM: To examine the different factors, dependent on epilepsy, its cause or the treatment, which can affect the cognitive development of children with epilepsy. DEVELOPMENT: To this end, a review was carried out of the studies that have provided data about the causes of cognitive disorders in children with epilepsy, and we suggest which children with epilepsy are at greater risk of suffering cognitive disorders and how they must be treated. CONCLUSIONS: Children with epilepsy often experience cognitive and behavioural difficulties for the rest of their lives. Sometimes these problems can be avoided, or at least improved. Being familiar with them, together with their early detection and treatment must be priorities for neuropaediatricians who treat children with epilepsy

Measurement of consensus with a reference

In this work we contribute to the formal analysis of the measurement of consensus in a society. Instead of approaching the topic from an absolute perspective we are concerned with a practical application: the proposal of a decision mechanism with respect to which consensus is measured. Surprisingly this produces a powerful unifying model, a restriction of which is deeply analysed. We also study the axiomatic properties of particular expressions for consensus with various salient social rules as a reference.Consensus; coherence; measurement; Borda rule; Copeland rule