Reverse intersystem crossing of single deuterated perylene molecules in a dibenzothiophene matrix

Biological and Soft Matter Physic

State-related electroencephalographic deviances in attention deficit hyperactivity disorder

The dynamic security region (DSR) of bulk power system has been accepted more and more in recent years for providing plenty of security information and good prospect in online application. This paper compares three linear approximations for the dynamic security region of network-reduction power systems. The three linear approximations are the Q-linear approximation based on the quadratic approximation of stability region, the L-linear approximation based on the linear approximation of stability region and the L0-linear approximation based on the invariant assumption of the normal vector for the boundary of the stability region corresponding to different control variable. The three linear approximations are all obtained with a same critical point lying just on the boundary of dynamic security region. The critical point is searched with numerical simulation. The accuracy of the three linear approximations is compared, using the linear approximation obtained with the curve fitting approach or the actual boundary of DSR searched as the benchmark. Simulation results in IEEE 3-machine 9-bus system and 10-machine 39-bus New England system show that all the three linear approximations display fairly accurate estimation. Furthermore, from the computational viewpoint, the L-linear and the L0-linear method are two alternative choices to approximate the dynamic security region.link_to_subscribed_fulltex

Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice

Epidemiological studies indicate that intellectual activity prevents or delays the onset of Alzheimer's disease (AD). Similarly, cognitive stimulation using environmental enrichment (EE), which increases adult neurogenesis and functional integration of newborn neurons into neural circuits of the hippocampus, protects against memory decline in transgenic mouse models of AD, but the mechanisms involved are poorly understood. To study the therapeutic benefits of cognitive stimulation in AD we examined the effects of EE in hippocampal neurogenesis and memory in a transgenic mouse model of AD expressing the human mutant β-amyloid (Aβ) precursor protein (APPSw,Ind). By using molecular markers of new generated neurons (bromodeoxiuridine, NeuN and doublecortin), we found reduced neurogenesis and decreased dendritic length and projections of doublecortin-expressing cells of the dentate gyrus in young APPSw,Ind transgenic mice. Moreover, we detected a lower number of mature neurons (NeuN positive) in the granular cell layer and a reduced volume of the dentate gyrus that could be due to a sustained decrease in the incorporation of new generated neurons. We found that short-term EE for 7 weeks efficiently ameliorates early hippocampal-dependent spatial learning and memory deficits in APPSw,Ind transgenic mice. The cognitive benefits of enrichment in APPSw,Ind transgenic mice were associated with increased number, dendritic length and projections to the CA3 region of the most mature adult newborn neurons. By contrast, Aβ levels and the total number of neurons in the dentate gyrus were unchanged by EE in APPSw,Ind mice. These results suggest that promoting the survival and maturation of adult generated newborn neurons in the hippocampus may contribute to cognitive benefits in AD mouse models

Weight loss in patients taking felbamate

Felbamate is a new antiepileptic drug (AED) with a good safety profile. Anorexia has been reported in patients taking felbamate, but the incidence and severity of this side effect have not been adequately investigated. We studied 65 patients with intractable seizures who received adjunctive felbamate therapy as part of clinical research trials or in a compassionate-use program. Mean treatment time on felbamate was 23 weeks (+/- SD 16; range, 6-116 weeks). Forty-nine patients (75%) lost weight during the trials. For subjects older than 15 years, there was a mean weight loss of 3.17 kg or 4.11% of body weight (T = 191.5, z = 4.18, p 4 kg, and seven patients (11%) lost > 8 kg. Adjunctive treatment of adults with severe epilepsy with felbamate may be associated with clinically significant weight loss