Grey Relational Analysis-Based Optimisation of Input Parameters of Incremental Forming Process Applied to the AA6061 Alloy

Incremental forming is mainly based on the deformation occurring locally on sheet metal. A hemispherical head tool deforms the sheet metal progressively, and its path is controlled by means of a CNC machine. Even though the process is a time-consuming one, the cost reduction connected with punches and dies makes this process attractive for rapid prototyping. In single point incremental forming, the quality of formability mainly depends on the forming parameters and the tool path generated. In this study, cone-shaped components were formed from AA6061 alloy sheets with a thickness of 1.15 mm. Factors, such as feed rate, spindle speed, and step depth are considered as input parameters to determine the output response in terms of surface roughness and wall thickness. Taguchi’s technique was used for conducting the experiments with the smallest number of repetitions to evaluate the output. Grey relational analysis was introduced to determine the optimal forming parameters with respect to the output response. The experiments conducted with the optimised parameters show a minimal deviation of 0.15% in the grade value compared to the predicted grade which is acceptable

Evaluation of central neuropathy in type 2 diabetes mellitus: a case control study

Background: Diabetes mellitus (DM) is a global pandemic affecting almost every organ in the body. Peripheral nervous system involvement in diabetes is well known but there are not many studies on central nervous system involvement. Visual evoked potential (VEP) is a sensitive, non-invasive test to detect central demyelination of optic nerve. The objective was to compare the visual evoked potentials in type-2 DM patients with that of healthy controls and to find out if any correlation is there with the duration and glycaemic control of the disease and to compare incidence of peripheral and central neuropathy in DM patients.Methods: Author included 50 DM patients and 50 age and sex matched controls. Patients with previous stroke, demyelination, diabetic retinopathy and other ophthalmological disorders were excluded. VEP was recorded using pattern reversal stimulation with EMG RMS MARK II machine and p100 latency was measured.Results: P100 latencies (ms) was significantly prolonged in diabetics with mean±SD of (111.24±5.28 ms) as compared to controls (101.30±1.66 ms) with p value <0.003. Also, there was significant correlation between duration of DM and P100 latency prolongation, but no significant correlation was present when compared with glycaemic control.Conclusions: Central neuropathy is very common in DM. It is related to duration of DM and not HbA1c unlike PNP which is related to both. Central neuropathy occurs even prior to development of retinopathy or PNP. Hence, VEP is a non-invasive and sensitive screening tool for early neurological involvement in DM

A framework-based wind forecasting to assess wind potential with improved grey wolf optimization and support vector regression

Wind energy is one of the most promising alternates of fossil fuels because of its abundant availability, low cost, and pollution-free attributes. Wind potential estimation, wind forecasting, and effective wind-energy management are the critical factors in planning and managing wind farms connected to wind-pooling substations. Hence, this study proposes a hybrid framework-based approach for wind-resource estimation and forecasting, namely IGWO-SVR (improved grey wolf optimization method (IGWO)-support vector regression (SVR)) for a real-time power pooling substation. The wind resource assessment and behavioral wind analysis has been carried out with the proposed IGWO-SVR optimization method for hourly, daily, monthly, and annual cases using 40 years of ERA (European Center for Medium-Range Weather Forecast reanalysis) data along with the impact of the El Niño effect. First, wind reassessment is carried out considering the impact of El Niño, wind speed, power, pressure, and temperature of the selected site Radhapuram substation in Tamilnadu, India and reported extensively. In addition, statistical analysis and wind distribution fitting are performed to demonstrate the seasonal effect. Then the proposed model is adopted for wind speed forecasting based on the dataset. From the results, the proposed model offered the best assessment report and predicted the wind behavior with greater accuracy using evaluation metrics, namely root mean square error (RMSE), mean absolute error (MAE), and mean squared error (MSE). For short-term wind speed, power, and El Niño forecasting, IGWO-SVR optimization effectively outperforms other existing models. This method can be adapted effectively in any potential locations for wind resource assessment and forecasting needs for better renewable energy management by power utilities

Experience paper on the operation of pilot project on oyster culture at Tuticorin

The technology of oyster culture was developed in India at the Central Marine Fisheries Research Institute. An experimental farm was established at Tuticorin bay in an area of 0.25 hectares. Different growout methods have been tried and it has been assessed that the shell string method could be practised with relatively low cost inputs with a production rate comparable to highly efficient systems such as rack and tray method or raft culture

Modeling of a Cable-Based Revolute Joint Using Biphasic Media Variable Stiffness Actuation

In recent times, safe interactions between humans and robots are required for innumerable tasks and environments. This safety can be achieved using compliance design and control of mechanisms. Cable-driven mechanisms are used when applications need to have light structures, meaning that their actuators must be relocated to ground and forces are transferred along tensioned cables. This paper presents a compliant cable-driven revolute joint using biphasic media variable stiffness actuators. Actuator's stiffness is controlled by changing pressure of control fluid into distribution lines. The used control fluid is biphasic, composed of separated gas and liquid fractions with predefined ratio. The mathematical model of the actuator is presented along with its position and stiffness model-based control, then, equations relating to the dynamics of the mechanism are provided with a joint stiffness and orientation controller. Results from simulations are discussed

Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat fetal hippocampus

Electronic cigarette (e-cig) use during pregnancy has become a major health concern in recent years and many view them as less harmful and may help quit or reduce combustible cigarettes. Implementing a state-of-the-art engineered vaping system, comprising an atomizer similar to those sold in vape shops, we aimed to utilize a translational e-cig inhalation delivery method to provide crucial information on the impact of prenatal e-cig aerosols on the developing brain hippocampal mTOR system in a rat model system. Gestational e-cig vaping significantly increased P-mTOR levels (p &lt; 0.05) in the rat fetal hippocampi in the nicotine group (comprising of VG/PG + nicotine) compared to the control and the juice (comprising of VG/PG) groups. Total mTOR expression was not different among groups. Immunofluorescence imaging demonstrated P-mTOR was detected exclusively in the granule cells of the dentate gyrus of the fetal hippocampus. E-cig did not alter DEPTOR, but RAPTOR and RICTOR were higher (p &lt; 0.05) in the Nicotine group. Gestational e-cig vaping with nicotine increased (p &lt; 0.05) the activity and expression of 4EBP1, p70S6K, but decreased (p &lt; 0.05) P-PKCα in the fetal hippocampi. In summary, dysregulation of mTORC1 and the related mTORC2, their activity, and downstream proteins together may play a critical role in e-cig-vaping-induced neurobiological phenotypes during development

Assessment of changes in the threadfin bream species composition using Markov chain

The threadfin bream landings in the Chennai Fisheries Harbour consistently declined from 5450 t in 1994 to 2406 t in '98. The catch rate also declined from 22.6 kg/trawl hour in '90 to 2.3 kg/h in '98. Markovian model is employed to assess the changes in species dominance over the 15 year period. Transition probabilities as well as the steady state probabilities are worked out separately for four species of threadfin breams. It was found that the probability of dominance of Nemipterus japonicus has decreased, indicating a major shift in the species composition of the threadfin breams. The possibility of short term prediction on the species dominance pattern by employing Markovian model is demonstrated

Abel-Jacobi maps for hypersurfaces and non commutative Calabi-Yau's

It is well known that the Fano scheme of lines on a cubic 4-fold is a symplectic variety. We generalize this fact by constructing a closed p-form with p=2n-4 on the Fano scheme of lines on a (2n-2)-dimensional hypersurface Y of degree n. We provide several definitions of this form - via the Abel-Jacobi map, via Hochschild homology, and via the linkage class, and compute it explicitly for n = 4. In the special case of a Pfaffian hypersurface Y we show that the Fano scheme is birational to a certain moduli space of sheaves on a p-dimensional Calabi--Yau variety X arising naturally in the context of homological projective duality, and that the constructed form is induced by the holomorphic volume form on X. This remains true for a general non Pfaffian hypersurface but the dual Calabi-Yau becomes non commutative.Comment: 34 pages; exposition of Hochschild homology expanded; references added; introduction re-written; some imrecisions, typos and the orbit diagram in the last section correcte

Micronutrient supplement intakes among collegiate and masters athletes: A cross-sectional study

ObjectiveIn our cross-sectional study, we evaluated micronutrient supplementation intake among Collegiate and Masters Athletes.MethodsWe conducted a cross-sectional study to assess micronutrient supplementation consumption in Collegiate and Masters Athletes, comparing sex and sport classification within each respective group. Micronutrient supplement consumption data were measured using a Food Frequency Questionnaire. A two-way analysis of variance was used to explore the differences among Collegiate and Masters Athletes' supplement intakes of the following vitamins and minerals: vitamins A, B6, B12, C, E, D, and calcium, folate, iron, magnesium niacin, riboflavin, selenium, thiamine, and zinc. When significant differences were found, a Bonferroni post hoc test was performed to identify specific group differences. The significance level was set a priori at p &lt; 0.05.ResultsA total of 198 athletes (105 females and 93 males) were included in the study. Participants were 36.16 ± 12.33 years of age. Collegiate male athletes had significantly greater vitamin A [1,090.51 ± 154.72 vs. 473.93 ± 233.18 mg retinol activity equivalents (RAE)/day] (p &lt; 0.036), folate [337.14 ± 44.79 vs. 148.67 ± 67.50 mcg dietary folate equivalents (DFE)/day] (p &lt; 0.027), and magnesium (65.35 ± 8.28 vs. 31.28 ± 12.48 mg/day) (p &lt; 0.031) intakes compared to Collegiate female athletes. Collegiate CrossFit Athletes (940.71 ± 157.54 mg/day) had a significantly greater vitamin C intake compared to Collegiate General Athletes (156.34 ± 67.79 mg/day) (p &lt; 0.005), Collegiate Triathletes (88.57 ± 148.53 mg/day) (p &lt; 0.027), Collegiate Resistance Training Athletes (74.28 ± 143.81 mg/day) (p &lt; 0.020), and Collegiate Powerlifters (175.71 ± 128.63 mg/day) (p &lt; 0.044). Masters females had significantly greater calcium intakes compared to Masters males (494.09 ± 65.73 vs.187.89 ± 77.23 mg/day, respectively) (p &lt; 0.002). Collegiate Runners (41.35 ± 6.53 mg/day) had a significantly greater iron intake compared to Collegiate Powerlifters (4.50 ± 6.53 mg/day) (p &lt; 0.024). Masters Swimmers (61.43 ± 12.10 mg/day) had significantly greater iron intakes compared to Masters General Athletes (13.97 ± 3.56 mg/day) (p &lt; 0.014), Masters Runners (17.74 ± 2.32 mg/day) (p &lt; 0.03), Masters Triathletes (11.95 ± 3.73 mg/day) (p &lt; 0.008), Masters CrossFit Athletes (15.93 ± 5.36 mg/day) (p &lt; 0.043), Masters Rowers (9.10 ± 3.36 mg/day) (p &lt; 0.003), and Masters Cyclists (1.71 ± 9.88 mg/day) (p &lt; 0.011). Masters Powerlifters (47.14 ± 9.65 mg/day) had significantly greater zinc intakes compared to Masters General Athletes (9.57 ± 2.84 mg/day) (p &lt; 0.015), Masters Runners (10.67 ± 1.85 mg/day) (p &lt; 0.017), Masters Triathletes (10.24 ± 2.98 mg/day) (p &lt; 0.020), Masters Rowers (9.33 ± 2.68 mg/day) (p &lt; 0.013), and Masters Cyclists (1.43 ± 7.88 mg/day) (p &lt; 0.019). There were no other significant differences among the other micronutrient supplement intakes between the sexes or among the sport classification.ConclusionWe reported significant differences among female and male Collegiate and Masters Athletes. Additionally, we reported significant differences among Collegiate and Masters Athletes sport classifications. Further research should examine both dietary and micronutrient supplement intake among Collegiate and Masters Athletes to examine the extent that athletes exceed the Recommended Dietary Allowances (RDA), and the potential effects on health and performance

NPY and MC4R Signaling Regulate Thyroid Hormone Levels during Fasting through Both Central and Peripheral Pathways

SummaryFasting-induced suppression of the hypothalamic-pituitary-thyroid (HPT) axis is an adaptive response to decrease energy expenditure during food deprivation. Previous studies demonstrate that leptin communicates nutritional status to the HPT axis through thyrotropin-releasing hormone (TRH) in the paraventricular nucleus (PVN) of the hypothalamus. Leptin targets TRH neurons either directly or indirectly via the arcuate nucleus through pro-opiomelanocortin (POMC) and agouti-related peptide/neuropeptide Y (AgRP/NPY) neurons. To evaluate the role of these pathways in vivo, we developed double knockout mice that lack both the melanocortin 4 receptor (MC4R) and NPY. We show that NPY is required for fasting-induced suppression of Trh expression in the PVN. However, both MC4R and NPY are required for activation of hepatic pathways that metabolize T4 during the fasting response. Thus, these signaling pathways play a key role in the communication of fasting signals to reduce thyroid hormone levels both centrally and through a peripheral hepatic circuit