La erupción submarina de La Restinga en la isla de El Hierro, Canarias: Octubre 2011-Marzo 2012

The first signs of renewed volcanic activity at El Hierro began in July 2011 with the occurrence of abundant, low-magnitude earthquakes. The increasing seismicity culminated on October 10, 2011, with the onset of a submarine eruption about 2 km offshore from La Restinga, the southernmost village on El Hierro. The analysis of seismic and deformation records prior to, and throughout, the eruption allowed the reconstruction of its main phases: 1) ascent of magma and migration of hypocentres from beneath the northern coast (El Golfo) towards the south rift zone, close to La Restinga, probably marking the hydraulic fracturing and the opening of the eruptive conduit; and 2) onset and development of a volcanic eruption indicated by sustained and prolonged harmonic tremor whose intensity varied with time. The features monitored during the eruption include location, depth and morphological evolution of the eruptive source and emission of floating volcanic bombs. These bombs initially showed white, vesiculated cores (originated by partial melting of underlying pre-volcanic sediments upon which the island of El Hierro was constructed) and black basanite rims, and later exclusively hollow basanitic lava balloons. The eruptive products have been matched with a fissural submarine eruption without ever having attained surtseyan explosiveness. The eruption has been active for about five months and ended in March 2012, thus becoming the second longest reported historical eruption in the Canary Islands after the Timanfaya eruption in Lanzarote (1730-1736). This eruption provided the first opportunity in 40 years to manage a volcanic crisis in the Canary Islands and to assess the interpretations and decisions taken, thereby gaining experience for improved management of future volcanic activity. Seismicity and deformation during the eruption were recorded and analysed by the Instituto Geográfico Nacional (IGN). Unfortunately, a lack of systematic sampling of erupted pyroclasts and lavas, as well as the sporadic monitoring of the depth and growth of the submarine vent by deployment of a research vessel, hampered a comprehensive assessment of hazards posed during volcanic activity. Thus, available scientific data and advice were not as high quality as they could have been, thereby limiting the authorities in making the proper decisions at crucial points during the crisis. The response in 2011-12 to the El Hierro eruption has demonstrated that adequate infrastructure and technical means exist in the Canary Islands for the early detection of potential eruptive hazards. However, it also has taught us that having detailed emergency management plans may be of limited value without an accompanying continuous, well-integrated scientific monitoring effort (open to national and international collaboration) during all stages of an eruption.Los primeros indicios de una posible erupción volcánica en El Hierro se percibieron a partir de julio de 2011 en forma de sismos de baja intensidad pero anormalmente numerosos. La intensificación de la sismicidad culminó con el inicio de la erupción submarina el 10 de octubre de 2011 a unos 2 km al sur de La Restinga. La sismicidad y deformación del terreno que precedieron y acompañaron a esta erupción han permitido reconstruir las principales fases de actividad volcánica: 1) generación y ascenso del magma con migración de los hipocentros sísmicos desde el norte, en el Golfo, hasta el rift sur, en La Restinga, marcando la apertura hidráulica del conducto magmático; y 2) inicio y continuidad de la erupción volcánica evidenciada por un tremor armónico continuo de intensidad variable en el tiempo. Las características observadas a lo largo de la erupción, principalmente localización, profundidad y evolución morfológica del foco emisor, así como emisión de materiales volcánicos flotantes, inicialmente con un núcleo blanco poroso (procedentes de la fusión parcial de sedimentos de la capa superior de la corteza oceánica anteriores a la construcción del edificio insular de El Hierro) envuelto por una corteza basanítica y después huecas (lava balloons), se han correspondido con una erupción submarina fisural profunda sin que nunca hayan intervenido mecanismos más explosivos tipo surtseyano. La erupción se mantuvo activa durante unos cinco meses, dándose por finalizada en marzo del 2012, convirtiéndose de este modo en la segunda erupción histórica más longeva de Canarias después de la de Timanfaya (1730-36) en Lanzarote. Esta erupción ha supuesto la primera oportunidad en 40 años de gestionar una crisis volcánica en Canarias y de analizar las observaciones e interpretaciones y las decisiones adoptadas, con objeto de mejorar la gestión de futuras crisis volcánicas. El Instituto Geográfico Nacional (IGN) se encargó de adquirir y analizar la información sísmica y de deformación durante todo el proceso. Sin embargo, no se dispuso inicialmente de un barco oceanográfico que realizara estudios sistemáticos de la profundidad y progresión de la erupción, así como de toma de muestras de los materiales emitidos (piroclastos y lavas), elementos claves para la determinación de la peligrosidad eruptiva. Estas deficiencias en el seguimiento científico del proceso eruptivo dificultaron en algunos momentos la toma de decisiones de protección civil. El análisis de la crisis ha puesto de manifiesto que, aunque se disponga de una infraestructura técnica adecuada para la detección temprana de crisis eruptivas en el archipiélago, de poco valen las medidas administrativas planificadas sin un seguimiento científico continuo e integrador del proceso eruptivo, abierto a la colaboración científica nacional e internacional

Bouncing Spallation Bombs During the 2021 La Palma Eruption, Canary Islands, Spain

Incandescent pyroclasts of more than 64 mm in diameter erupted from active volcanoes are known as bombs and pose a significant hazard to life and infrastructure. Volcanic ballistic projectile hazard assessment normally considers fall as the main transport process, estimating its intensity from bomb location and impact cratering. We describe ballistically ejected bombs observed during the late October 2021 episode of eruption at La Palma (Canary Islands) that additionally travelled downhill by rolling and bouncing on the steep tephra-dominated cone. These bouncing bombs travelled for distances >1 km beyond their initial impact sites, increasing total travel distance by as much as 100%. They left multiple impact craters on their travel path and frequently spalled incandescent fragments on impact with substrate, leading to significant fire hazard for partially buried trees and structures far beyond the range of ballistic transport. We term these phenomena as bouncing spallation bombs. The official exclusion zone encompassed this hazard at La Palma, but elsewhere bouncing spallation bombs ought to be accounted for in risk assessment, necessitating awareness of an increased hazard footprint on steep-sided volcanoes with ballistic activity

The 2021 eruption of the Cumbre Vieja volcanic ridge on La Palma, Canary Islands

Almost exactly half a century after the eruption of the Teneguía Volcano on La Palma (26 October to 28 November 1971), a new eruption occurred on the island and lasted for 85 days from 19 September until 13 December 2021. This new eruption opened a volcanic vent complex on the western flank of the Cumbre Vieja rift zone, the N-S elongated polygenetic volcanic ridge that has developed on La Palma over the last c. 125 ka. The Cumbre Vieja ridge is the volcanically active region of the island and the most active one of the Canary Islands, hosting half of all the historically recorded eruptive events in the archipelago. The 2021 La Palma eruption has seen no direct loss of human life, thanks to efficient early detection and sensible management of the volcanic crisis by the authorities, but more than 2800 buildings and almost 1000 hectares of plantations and farmland were affected by lava flows and pyroclastic deposits. Satellite surveillance enabled accurate mapping of the progressive buildup of the extensive and complex basaltic lava field, which together with monitoring of gas emissions informed the timely evacuation of local populations from affected areas. Lava flows that reached the sea constructed an extensive system of lava deltas and platforms, similar to events during earlier historical eruptions such as in 1712, 1949 and 1971. Long-term challenges in the aftermath of the eruption include protection of drainage systems from potential redistribution of tephra during high rainfall events, the use of the large surplus quantities of ash in reconstruction of buildings and in agriculture, and the crucial concerns of where and how rebuilding should and could occur in the aftermath of the eruption. Finally, there remain strong financial concerns over insurance for properties consumed or damaged by the eruption in the light of future volcanic hazards from the Cumbre Vieja volcanic ridge.Peer reviewe

Identification and Characterization of Peripheral T-Cell Lymphoma-Associated SEREX Antigens

Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL). With notable exceptions such as ALK+ anaplastic large cell lymphoma (ALCL, ALK+), the molecular abnormalities in PTCL remain poorly characterised. We had previously identified circulating antibodies to ALK in patients with ALCL, ALK+. Thus, as a strategy to identify potential antigens associated with the pathogenesis of PTCL, not otherwise specified (PTCL, NOS), we screened a testis cDNA library with sera from four PTCL, NOS patients using the SEREX (serological analysis of recombinant cDNA expression libraries) technique. We identified nine PTCL, NOS-associated antigens whose immunological reactivity was further investigated using sera from 52 B- and T-cell lymphoma patients and 17 normal controls. The centrosomal protein CEP250 was specifically recognised by patients sera and showed increased protein expression in cell lines derived from T-cell versus B-cell malignancies. TCEB3, BECN1, and two previously uncharacterised proteins, c14orf93 and ZBTB44, were preferentially recognised by patients' sera. Transcripts for all nine genes were identified in 39 cancer cell lines and the five genes encoding preferentially lymphoma-recognised antigens were widely expressed in normal tissues and mononuclear cell subsets. In summary, this study identifies novel molecules that are immunologically recognised in vivo by patients with PTCL, NOS. Future studies are needed to determine whether these tumor antigens play a role in the pathogenesis of PTCL

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)