Actuator saturation and its influence on vibration reduction by actively controlled flaps

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77213/1/AIAA-2001-1467-982.pd

Aeroelastic Response of Bird-Damaged Fan Blades Using a Coupled CFD/CSD Framework

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140712/1/6.2014-0334.pd

Forced and Aeroelastic Responses of Bird-Damaged Fan Blades: A Comparison and Its Implications

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140641/1/1.C033424.pd

A generalization of an inequality of Zygmund

The well known Bernstein Inequallty states that if D is a disk centered at the origin with radius R and if p(z) is a polynomial of degree n, then maxz∈D|p′(z)|≤nRmaxz∈D|p(z)| with equality iff p(z)=AZn. However it is true that we have the following better inequallty: maxz∈D|p′(z)|≤nRmaxz∈D|Rep(z)| with equality iff p(z)=AZn

Introduction to Special Issue: Dementia and Music

This special issue follows two previous special issues on music and neurological disorders (April 2008, Volume 23/Issue 4 and April 2010, Volume 25/Issue 4). Like its predecessors, the issue presents studies employing a patient-based approach to music perception, cognition, and emotion. Whereas the earlier issues dealt with acquired and congenital disorders and impairments, the present issue focuses on dementia, primarily on its most common form, Alzheimer\u27s disease (AD)

Intonation processing in congenital amusia: discrimination, identification and imitation

This study investigated whether congenital amusia, a neuro-developmental disorder of musical perception, also has implications for speech intonation processing. In total, 16 British amusics and 16 matched controls completed five intonation perception tasks and two pitch threshold tasks. Compared with controls, amusics showed impaired performance on discrimination, identification and imitation of statements and questions that were characterized primarily by pitch direction differences in the final word. This intonation-processing deficit in amusia was largely associated with a psychophysical pitch direction discrimination deficit. These findings suggest that amusia impacts upon one’s language abilities in subtle ways, and support previous evidence that pitch processing in language and music involves shared mechanisms

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes.

Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo. ACF generates and maintains nucleosome spacing by constantly moving a nucleosome towards the longer flanking DNA faster than the shorter flanking DNA. How the enzyme rapidly moves back and forth between both sides of a nucleosome to accomplish bidirectional movement is unknown. Here we show that nucleosome movement depends cooperatively on two ACF molecules, indicating that ACF functions as a dimer of ATPases. Further, the nucleotide state determines whether the dimer closely engages one or both sides of the nucleosome. Three-dimensional reconstruction by single-particle electron microscopy of the ATPase-nucleosome complex in an activated ATP state reveals a dimer architecture in which the two ATPases face each other. Our results indicate a model in which the two ATPases work in a coordinated manner, taking turns to engage either side of a nucleosome, thereby allowing processive bidirectional movement. This novel dimeric motor mechanism differs from that of dimeric motors such as kinesin and dimeric helicases that processively translocate unidirectionally and reflects the unique challenges faced by motors that move nucleosomes

Adaptive Bayesian Iterative Transmission Reconstruction for Attenuation Correction in Myocardial Perfusion Imaging with SPECT/Slow-Rotation Low-Output CT Systems

Objectives. SPECT/slow-rotation low-output CT systems can produce streak artifacts in filtered backprojection (FBP) attenuation maps, impacting attenuation correction (AC) in myocardial perfusion imaging. This paper presents an adaptive Bayesian iterative transmission reconstruction (ABITR) algorithm for more accurate AC. Methods. In each iteration, ABITR calculated a three-dimensional prior containing the pixels with attenuation coefficients similar to water, then used it to encourage these pixels to the water value. ABITR was tested with a cardiac phantom and 4 normal patients acquired by a GE Millennium VG/Hawkeye system. Results. FBP AC and ABITR AC produced similar phantom results. For the patients, streak artifacts were observed in the FBP and ordered-subsets expectation-maximization (OSEM) maps but not in the ABITR maps, and ABITR AC produced more uniform images than FBP AC and OSEM AC. Conclusion. ABITR can improve the quality of the attenuation map, producing more uniform images for normal studies