Mutual Phase Locking of Very Nonidentical Spin Torque Nanooscillators via Spin Wave Interaction

In this paper the mutual phase locking theory of very nonidentical spin-torque nanooscillators, which is based on the Slavin-Tiberkevich model, considering the theory of nonlinear oscillations, is developed. Using generalized Adler equation we calculate phase-locking region of the system with spinwave coupling in the parameter plane - distance between nanocontacts and radii difference. We describe trajectories of such a system in the phase space and show the effect of a broadband synchronization. We introduce a generalization of this approach to the ensembles of spin-torque nanooscillatorsComment: 6 pages, 2 figure

Functional modes of proteins are among the most robust ones

It is shown that a small subset of modes which are likely to be involved in protein functional motions of large amplitude can be determined by retaining the most robust normal modes obtained using different protein models. This result should prove helpful in the context of several applications proposed recently, like for solving difficult molecular replacement problems or for fitting atomic structures into low-resolution electron density maps. Moreover, it may also pave the way for the development of methods allowing to predict such motions accurately.Comment: 4 pages, 5 figure

New Rheumatoid Arthritis Treatments for ‘Old’ Patients : Results of a Systematic Review

Introduction: In the last 20 years, biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) have become available for treating rheumatoid arthritis (RA), and a treat-to-target strategy has been introduced. We hypothesise that these advances should have resulted in changes to the characteristics of patients with RA participating in clinical trials of the newest therapies. This study determined whether the baseline characteristics of patients with RA enrolled in clinical trials have changed in the past decade versus patients participating in earlier RA studies. Methods: This secondary analysis was based on randomised controlled trials (RCTs) identified in a systematic literature review. Baseline characteristics of patients with RA with inadequate response to conventional synthetic DMARDs were compared between RCTs published in 1999\u20132009 and those published in 2010\u20132017 using random-effects meta-analyses. Results: Forty RCTs were analysed: 22 from 1999\u20132009 and 18 from 2010\u20132017. No significant difference between the two timeframes and no obvious trend over time were observed for age, gender, disease duration, rheumatoid factor status, tender and swollen joint counts, physician and patient global assessments of disease activity, and pain scores. Variability between RCTs was high. Similar results were observed for Disease Activity Scores and Health Assessment Questionnaire-Disability Index scores, but with low variability between RCTs. Conclusion: The baseline characteristics of patients with RA participating in RCTs do not appear to have changed in the last decade despite the availability of new treatments and a different treatment approach. Further research should determine the impact of baseline patient characteristics on patients\u2019 response to RA treatments

Atropelamentos e novos registros para tatu-canastra (Priodontes maximus) no centro-oeste do Brasil

Despite the widespread distribution of the giant armadillo Priodontes maximus, this species isfound at low densities, often in disrupted populations. Here we report 12 new records, including five incidentsof roadkill of P. maximus in different points of the Cerrado and one in an Atlantic Forest fragment in centralwesternBrazil. In addition to the relevant records, we discuss the negative effects of roadkills, which is a seriousissue for the conservation and maintenance of local populations of giant armadillo.Atropelamentos e novos registros para tatu-canastra (Priodontes maximus) no centro-oeste do Brasil. Apesar da ampla distribuição do tatu-canastra Priodontes maximus, esta espécie apresenta baixas densidades em populações não conectadas. Aqui, relatamos 12 novos registros, incluindo cinco atropelamentos rodoviários de P. maximus em diferentes pontos de Cerrado e um em fragmento de Floresta Atlântica no centro-oeste do Brasil. Além dos registros relevantes, discutimos o efeito negativo da perda de espécimes por atropelamentos em estradas, o qual é um problema sério para a conservação e manutenção de populações locais de tatu-canastra.Fil: Hannibal, Wellington. Universidade Federal de Goiás; BrasilFil: Leme Da Cunha, Nicolay. Universidade Federal do Mato Grosso do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Dalponti, Guilherme. Universidade Federal do Mato Grosso do Sul; BrasilFil: Oliveira, Seixas R.. Instituto Federal Goiano; BrasilFil: Pereira, Katia R. F.. Universidade Anhaguera; Brasi

Comparison of three soil health indicators between different vegetative strip compositions

Contemporary evidence shows biotic factors play a prominent role in the soil health and the provision of soil functions. Herbaceous grassland species differ in their modulation of soil communities, effects on soil components, as well the processes they interact with or regulate. In this study, we aimed to investigate the impact of different plant species communities on soil health, as quantified by soil physical (water infiltration), chemical (soil organic matter) and biological (Collembola community data) indicators. Data was collected from an existing long-term field trial in the UK, planted to either forb-dominated composition, grass species dominated composition or a multipurpose mixture of forb and grass species. Results showed that plant community can determine soil water infiltration rates, particularly with observed increased soil organic matter (SOM) and epigeic Collembola abundances. The results presented here add evidence that plant communities planted as vegetative buffer strips can be specifically tailored to support soil health development and maintenance

Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque

Interest in the use of contrast-enhanced MRI to enable in vivo specific characterization of atherosclerotic plaques is increasing. In this study the intrinsic ability of three differently sized gadolinium-based contrast agents to permeate different mouse plaque phenotypes was evaluated with MRI. A tapered cast was implanted around the right carotid artery of apoE-/- mice to induce two different plaque phenotypes: a thin cap fibroatheroma (TCFA) and a non-TCFA lesion. Both plaques were allowed to develop over 6 and 9 weeks, leading to an intermediate and advanced lesion, respectively. Signal enhancement in the carotid artery wall, following intravenous injection of Gd-HP-DO3A as well as paramagnetic micelles and liposomes was evaluated. In vivo T1-weighted MRI plaque enhancement characteristics were complemented by fluorescence microscopy and correlated to lesion phenotype. The two smallest contrast agents, i.e. Gd-HP-DO3A and micelles, were found to enhance contrast in T1-weighted MR images of all investigated plaque phenotypes. Maximum contrast enhancement ranged between 53 and 70% at 6¿min after injection of Gd-HP-DO3A with highest enhancement and longest retention in the non-TCFA lesion. Twenty-four hours after injection of micelles maximum contrast enhancement ranged between 24 and 35% in all plaque phenotypes. Administration of the larger liposomes did not cause significant contrast enhancement in the atherosclerotic plaques. Confocal fluorescence microscopy confirmed the MRI-based differences in plaque permeation between micelles and liposomes. Plaque permeation of contrast agents was strongly dependent on size. Our results implicate that, when equipped with targeting ligands, liposomes are most suitable for the imaging of plaque-associated endothelial markers due to low background enhancement, whereas micelles, which accumulate extravascularly on a long timescale, are suited for imaging of less abundant markers inside plaques. Low molecular weight compounds may be employed for target-specific imaging of highly abundant extravascular plaque-associated target