435 research outputs found
Hubungan Kecerdasan Spiritual Dengan Resiliensi Pada Siswa Yang Mengikuti Program Akselerasi
The study was conducted to determine the relationship between spiritual intelligence with resilience in students who attend an accelerated program. The populations in this study were students at SMAN acceleration in Malang as many as 194 students. The samples in this study were female students of SMAN accelerated program in the city of Malang by 55 students. Sampling in this study use purposive sampling technique. The process of data analysis is the product moment correlation. Results for resilience scale of 60 items made as many as 54 valid item items. As for the scale of spiritual intelligence of 60 items made, as much as 55 valid item items. Reliability test results obtained values for resilience scale reliability coefficient of 0.917. As for the spiritual intelligence scale values obtained reliability coefficient of 0.935 so that the reliability test results showed the existence of a reliable degree. The results of the analysis of data obtained r count greater than r table (0.687> 0.266) with a correlation index (r xy) of 0.687 at a significance level of 0.05 which indicates that there is a positive relationship between the resilience of the spiritual intelligence, so that the working hypothesis (Ha) states that there is a relationship between resilience with spiritual intelligence, accepted
Scholarly Needs for Text Analysis Resources: A User Assessment Study for the HathiTrust Research Center
The HathiTrust Research Center (HTRC) is undertaking a study to better understand the needs of current and potential users of the center’s tools and services for computational text analysis. In this paper, we report on the results of the first phase of the study, which consisted of interviews with scholars, administrators, and librarians whose work involves text data mining. Our study reveals that text analysis workflows are specific to the individual research project and are often nonlinear. In spite of, and in some cases because of, the wealth of textual data available, scholars find it most difficult to locate, access, and curate textual data for their research. While the goals of the study directly relate to research and development for the HTRC, our results are useful for other large-scale data providers developing solutions for allowing computational access to their content
Being active supports client control over health care
The purpose of this study was to identify how healthcare clients achieve and maintain a sense of control over their health. The literature review conducted refers to: (i) key definitions of control, (ii) locus of control, and (iii) control and wellbeing. Participants with a range of acute and chronic health conditions and who had been hospitalised at some point were selected for the study. Symbolic interactionism (Blumer, 1969) and modified grounded theory of Strauss & Corbin (1998) provided the frameworks for this study. During the six month study period, data were collected from sixty participants and included interviews, participant observation, reviewing participants' records (nursing care plans, nursing notes and case histories), the nursing units' philosophy, organisational charts, policies and procedures, annual reports, consumer brochures and any other relevant information sources. Findings from the study indicated that participants moved from feeling vulnerable to having a sense of control through to being purposefully active. Vulnerability was associated with: (i) having limited choices in respect to their health, (ii) lacking adequate health information to make choices, (iii) being ignored by health providers with respect to their needs, and (iv) lacking friend/family supports. Purposefully activating was associated with three major categories: (i) reflecting, (ii) being self-determiningly involved and (iii) normalising. Findings from this study could be used by health care clients who want a sense of control over their health care, and also by health care providers who wish to support clients in the healthcare process.C
THE CORRELATION BETWEEN LEVEL OF KNOWLEDGE ABOUT LEUCORRHOEA AND PREVENTION OF LEUCORRHOEA BEHAVIOR ON TEENAGE GIRLS AT SMA DHARMA PRAJA DENPASAR: HUBUNGAN TINGKAT PENGETAHUAN TENTANG KEPUTIHAN DENGAN PERILAKU PENCEGAHAN KEPUTIHAN PADA REMAJA PUTRI DI SMA DHARMA PRAJA DENPASAR
Keputihan atau Fluor albus adalah suatu gejala berupa cairan yang tidak berupa darah yang keluar dari organ genetalia. Di Indonesia sekitar 90% wanita berpotensi mengalami keputihan karena negara Indonesia adalah daerah yang beriklim tropis, sehingga jamur muda berkembang yang mengakibatkan banyaknya kasus keputihan. Keputihan pada remaja dapat disebabkan karena perilaku pencegahan keputihan yang kurang baik. Pengetahuan adalah salah satu faktor terbentuknya perilaku pada remaja. Penelitian ini bertujuan untuk menganalisa hubungan tingkat pengetahuan tentang keputihan dengan perilaku pencegahan keputihan pada remaja putri di SMA Dharma Praja Denpasar. Jenis penelitian yaitu kuantitatif dengan menggunakan metode desain korelasi deskriptif dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah pelajar yang berjenis kelamin perempuan kelas X di SMA Dharma Praja sebanyak 124 orang. Teknik pengambilan sampel yaitu menggunakan teknik simple random sampling dengan jumlah sampel sebanyak 95 responden. Uji statistik menggunakan uji korelasi Spearman Rank. Hasil penelitian menunjukkan remaja dengan pengetahuan yang baik tentang keputihan lebih banyak memiliki perilaku yang baik dalam pencegahan keputihan (82,3%). Hasil uji statistik menunjukkan ada hubungan yang signifikan dengan kekuatan kuat antara tingkat pengetahuan tentang keputihan dengan perilaku pencegahan keputihan pada remaja putri di SMA Dharma Praja Denpasar, dengan nilai signifikansi yaitu sebesar 0,000 dengan nilai koefisien korelasi yaitu 0,722. Semakin tinggi pengetahuan remaja maka akan semakin baik perilaku remaja terhadap pencegahan keputihan. Berdasarkan penelitian ini, disarankan bagi tenaga kesehatan diharapkan dapat bekerjasama dengan sekolah dalam memberikan informasi kepada siswi tentang kesehatan reproduksi khususnya keputihan.Leucorrhoea is a symptom in the form of a liquid that is not in the form of blood coming out of genetal organs. In Indonesia, about 90% of women have the potential to experience leucorrhoea because the country of Indonesia is a tropical climate, so young fungi develop which result in many cases of leucorrhoea. Leucorrhoea in teenagers can be caused by bad behavior of leucorrhoea precaution. Knowledge is a factor to build behavior in teenager. This study aims to analyze the correlation between level knowledge about leucorrhoea with prevention behavior leucorrhoea for teenage girls at SMA Dharma Praja Denpasar. The type of research is quantitative by using descriptive correlation design method with cross sectional approach. The population in this study were female students of class X at SMA Dharma Praja Denpasar as many 124 people. The technique sampling is using simple random sampling with total sample of 95 respondents. Statistical tests using the Spearman Rank correlation test. The results showed that more teenager with good knowledge of leucorrhoea have good behavior in leucorrhoea precaution (82.3%). The results of the statistical tests show that there is a significant correlation with the strong strength between knowledge about Leucorrhoea with prevention behavior leucorrhoea for teenage girls at Sma Dharma Praja Denpasar, with a significance value of 0,000 with a correlation coefficient of 0.722. The higher adolescent's knowledge, it will better for behavior of adolescents towards prevention of leucorrhoea. Based on this study, it is recommended that health workers be expected to work together with schools in providing information to students about reproductive health, especially leucorrhoea
Prevalence, Cardiac Phenotype, and Outcomes of Transthyretin Variants in the UK Biobank Population
Importance: The population prevalence of cardiac transthyretin amyloidosis (ATTR) caused by pathogenic variation in the TTR gene (vATTR) is unknown.
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Objective: To estimate the population prevalence of disease-causing TTR variants and evaluate associated phenotypes and outcomes.
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Design, Setting, and Participants: This population-based cohort study analyzed UK Biobank (UKB) participants with whole-exome sequencing, electrocardiogram, and cardiovascular magnetic resonance data. Participants were enrolled from 2006 to 2010, with a median follow-up of 12 (IQR, 11-13) years (cutoff date for the analysis, March 12, 2024). Sixty-two candidate TTR variants were extracted based on rarity (minor allele frequency ≤0.0001) and/or previously described associations with amyloidosis if more frequent.
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Exposure: Carrier status for TTR variants.
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Main Outcomes and Measures: Associations of TTR carrier status with vATTR prevalence and cardiovascular imaging and electrocardiogram traits were explored using descriptive statistics. Associations between TTR carrier status and atrial fibrillation, conduction disease, heart failure, and all-cause mortality were evaluated using adjusted Cox proportional hazards models. Genotypic and diagnostic concordance was examined using International Statistical Classification of Diseases, Tenth Revision codes from the hospital record.
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Results: The overall cohort included 469 789 UKB participants (mean [SD] age, 56.5 [8.1] years; 54.2% female and 45.8% male). A likely pathogenic/pathogenic (LP/P) TTR variant was detected in 473 (0.1%) participants, with Val142Ile being the most prevalent (367 [77.6%]); 91 individuals (0.02%) were carriers of a variant of unknown significance . The overall prevalence of LP/P variants was 0.02% (105 of 444 243) in participants with European ancestry and 4.3% (321 of 7533) in participants with African ancestry. The LP/P variants were associated with higher left ventricular mass indexed to body surface area (β = 4.66; 95% CI, 1.87-7.44), and Val142Ile was associated with a longer PR interval (β = 18.34; 95% CI, 5.41-31.27). The LP/P carrier status was associated with a higher risk of heart failure (hazard ratio [HR], 2.68; 95% CI, 1.75-4.12) and conduction disease (HR, 1.88; 95% CI, 1.25-2.83). Higher all-cause mortality risk was observed for non-Val142Ile LP/P variants (HR, 1.98; 95% CI, 1.06-3.67). Thirteen participants (2.8%) with LP/P variants had diagnostic codes compatible with cardiac or neurologic amyloidosis. Variants of unknown significance were not associated with outcomes.
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Conclusions and Relevance: This study found that approximately 1 in 1000 UKB participants were LP/P TTR variant carriers, exceeding previously reported prevalence. The findings emphasize the need for clinical vigilance in identifying individuals at risk of developing vATTR and associated poor outcomes
Large rivers and orogens: the evolution of the Yarlung Tsangpo–Irrawaddy system and the eastern Himalayan syntaxis
The eastern Himalayan syntaxis has experienced some of the highest rates of deformation and erosion in the orogen during the Late Cenozoic, and the Yarlung Tsangpo, Brahmaputra, Irrawaddy, Salween, and Mekong rivers are the key erosional systems in that region. The Yarlung Tsangpo drains southern Tibet and the deep Siang River gorge through the eastern Himalayan syntaxis before joining the Brahmaputra in northeastern India. It has been proposed that the Yarlung Tsangpo drained into other large rivers of southern Asia, such as the Irrawaddy, Salween and Red River. We have used uranium/lead dating and hafnium measurements of detrital zircons from Cenozoic sedimentary deposits in Central Myanmar to demonstrate that the Yarlung Tsangpo formerly drained into the Irrawaddy River in Myanmar through the eastern syntaxis, and that this ancient river system was established by (at least) the Middle–Late Eocene. The Yarlung Tsangpo–Irrawaddy river disconnected in the Early Miocene driven by increased deformation in the eastern syntaxis and headward erosion by tributaries of the Brahmaputra. Our results highlight the significance of the sedimentary record of large orogen-parallel rivers and provide key chronological constraints on landscape evolution during the Early Miocene phase of the Himalayan orogeny
Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques
Atherosclerosis is a major cause of mortality and morbidity, which is mainly driven by complications such as myocardial infarction and stroke. These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. Here we show that near-infrared autofluorescence is associated with the presence of intraplaque hemorrhage and heme degradation products, particularly bilirubin by using our recently created mouse model, which uniquely reflects plaque instability as seen in humans, and human carotid endarterectomy samples. Fluorescence emission computed tomography detecting near-infrared autofluorescence allows in vivo monitoring of intraplaque hemorrhage, establishing a preclinical technology to assess and monitor plaque instability and thereby test potential plaque-stabilizing drugs. We suggest that near-infrared autofluorescence imaging is a novel technology that allows identification of atherosclerotic plaques with intraplaque hemorrhage and ultimately holds promise for detection of high-risk plaques in patients
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