SNOWBOARDER'S FRACTURE: CHANGING JOINT MECHANICS BY FOOT POSITION DURING A SIMULATED LANDING TASK

A high proportion of fractures to the lateral process of the talus (LPT) has been reported in snowboarding, which accounted for 34% of all ankle fractures (Kirkpatrick et al., 1998). A fracture to the LPT is an injury unique to snowboarders and is often misdiagnosed by physicians as an anterolateral ankle sprain. LPT fractures often involve the articular surface of the subtalar joint and it has been shown that misdiagnosis may lead to severe degeneration of the ankle joint and long term morbidity (Boon et aI., 1999). The mechanism of this injury has been studied intensively. LPT fractures are high impact injuries, landing after aerial manoeuvres is thought to be the major cause of LPT fractures (Boon et aI., 1999). In a cadaver study no fractures to the LPT were recorded under purely dorsalflexed conditions but in six of the eight specimens fractures occurred with the addition of 20° external rotation. An axial load of 2200 -8900 N was required to produce a fracture (LPT) in this position. It was proposed by Boon and colleagues tr.at the subsequent 'opening' of the ankle joint seen with heel inversion and external rotation of the talus results in the lateral process shifting upwards on the posterior articular process of the calcaneus. The purpose of this study was to simulate a snowboard landing in the laboratory with using an inverse dynamics approach to calculate effective joint loading for different binding alignments. It was hypothesised that the 'stance' chosen will affect loading and that an optimum foot alignment will help to minimise joint load

Galaxy pairs in the Sloan Digital Sky Survey - IX: Merger-induced AGN activity as traced by the Wide-field Infrared Survey Explorer

Interactions between galaxies are predicted to cause gas inflows that can potentially trigger nuclear activity. Since the inflowing material can obscure the central regions of interacting galaxies, a potential limitation of previous optical studies is that obscured Active Galactic Nuclei (AGNs) can be missed at various stages along the merger sequence. We present the first large mid-infrared study of AGNs in mergers and galaxy pairs, in order to quantify the incidence of obscured AGNs triggered by interactions. The sample consists of galaxy pairs and post-mergers drawn from the Sloan Digital Sky Survey that are matched to detections by the Wide Field Infrared Sky Explorer (WISE). We find that the fraction of AGN in the pairs, relative to a mass-, redshift- and environment-matched control sample, increases as a function of decreasing projected separation. This enhancement is most dramatic in the post-merger sample, where we find a factor of 10-20 excess in the AGN fraction compared with the control. Although this trend is in qualitative agreement with results based on optical AGN selection, the mid-infrared selected AGN excess increases much more dramatically in the post-mergers than is seen for optical AGN. Our results suggest that energetically dominant optically obscured AGNs become more prevalent in the most advanced mergers, consistent with theoretical predictions.Comment: 8 pages, 7 figures accepted to MNRAS (with minor revisions

Rapid, multiplexed microfluidic phage display

The development of a method for high-throughput, automated proteomic screening could impact areas ranging from fundamental molecular interactions to the discovery of novel disease markers and therapeutic targets. Surface display techniques allow for efficient handling of large molecular libraries in small volumes. In particular, phage display has emerged as a powerful technology for selecting peptides and proteins with enhanced, target-specific binding affinities. Yet, the process becomes cumbersome and time-consuming when multiple targets are involved.Here we demonstrate for the first time a microfluidic chip capable of identifying high affinity phage displayed peptides for multiple targets in just a single round and without the need for bacterial infection. The chip is shown to be able to yield well-established control consensus sequences while simultaneously identifying new sequences for clinically important targets. Indeed, the confined parameters of the device allow not only for highly controlled assay conditions but also introduce a significant time-reduction to the phage display process. We anticipate that this easily-fabricated, disposable device has the potential to impact areas ranging from fundamental studies of protein, peptide, and molecular interactions, to applications such as fully automated proteomic screening

Hidden Hearing Loss Impacts the Neural Representation of Speech in Background Noise

Many individuals with seemingly normal hearing abilities struggle to understand speech in noisy backgrounds. To understand why this might be the case, we investigated the neural representation of speech in the auditory midbrain of gerbils with “hidden hearing loss” through noise exposure that increased hearing thresholds only temporarily. In noise-exposed animals, we observed significantly increased neural responses to speech stimuli, with a more pronounced increase at moderate than at high sound intensities. Noise exposure reduced discriminability of neural responses to speech in background noise at high sound intensities, with impairment most severe for tokens with relatively greater spectral energy in the noise-exposure frequency range (2–4 kHz). At moderate sound intensities, discriminability was surprisingly improved, which was unrelated to spectral content. A model combining damage to high-threshold auditory nerve fibers with increased response gain of central auditory neurons reproduced these effects, demonstrating that a specific combination of peripheral damage and central compensation could explain listening difficulties despite normal hearing thresholds

Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors

The development of a robust method for integrating high-performance semiconductors on flexible plastics could enable exciting avenues in fundamental research and novel applications. One area of vital relevance is chemical and biological sensing, which if implemented on biocompatible substrates, could yield breakthroughs in implantable or wearable monitoring systems. Semiconducting nanowires (and nanotubes) are particularly sensitive chemical sensors because of their high surface-to-volume ratios. Here, we present a scalable and parallel process for transferring hundreds of pre-aligned silicon nanowires onto plastic to yield highly ordered films for low-power sensor chips. The nanowires are excellent field-effect transistors, and, as sensors, exhibit parts-per-billion sensitivity to NO_2, a hazardous pollutant. We also use SiO_2 surface chemistries to construct a 'nano-electronic nose' library, which can distinguish acetone and hexane vapours via distributed responses. The excellent sensing performance coupled with bendable plastic could open up opportunities in portable, wearable or even implantable sensors

A spatially explicit habitat selection model incorporating home range behavior

Understanding habitat selection is of primary interest in theoretical and applied ecology. One approach is to infer habitat selection processes from differences in population densities between habitats using methods such as isodar and isoleg analysis. Another approach is to directly observe the movements of individuals. However, habitat selection models based on movement data often fail to adequately incorporate spatial processes. This is problematic if the probability of selecting a particular habitat is dependent upon its spatial context. This would occur, for example, where organisms exhibit home range behavior and the choice of habitat is dependent on its location relative to the home range. In this paper we present a spatially explicit habitat selection model for movement data that incorporates home range behavior as a spatial process. Our approach extends a previous model by formulating the probability of selecting a habitat as a function of its distance from the animal's current location and home range center. We demonstrate that these enhancements lead to more parsimonious models when applied to a koala radiotracking data set from eastern Australia. This approach could also be applied to modeling other spatial habitat selection processes, leading to more biologically meaningful models for a range of species and applications

Essential mineral intake during pregnancy and its association with maternal health and birth outcomes in South East Queensland, Australia

Micronutrient supplements are often recommended during pregnancy, yet their role and necessity remain poorly understood in the Australian population. This study aimed to determine the essential mineral intake of a population of pregnant women in South East Queensland and investigate the effects of supplements on their micronutrient status and birth outcomes. Women completing the Oral Glucose Tolerance Test at two South East Queensland hospitals between 180 and 210 days gestation provided fasting blood samples and dietary data using the Maternal Outcomes and Nutrition Tool (n = 127). Birth outcomes were sourced from medical records. Serum elemental profiles were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis. Intake of 8 essential minerals was compared with Australian dietary recommendations; matched serum mineral levels were compared with the current Queensland pregnancy reference ranges. Data were examined using cross-sectional cohort design and independent sample t-tests. Supplement use had no significant influence on serum values of trace elements or the incidence of hypertensive disorders, gestational diabetes, preterm birth or infant birthweight. Dietary selenium, zinc and iodine were significantly higher in women birthing beyond 41 completed weeks; selenium (P = .026) and zinc (P = .034) both made unique contributions to the regression models when controlling for confounders. Women exhibited adequate to excessive serum micronutrient levels compared with pregnancy reference ranges, a finding consistent with dietary intake calculations. Data suggest that excessive essential mineral intake contributed to prolonged pregnancy in this cohort, supporting previous studies in this population. Further research is required to determine individual needs and eliminate the potential for harm before recommending pregnancy supplements

Estimating Recent Local Impacts of Sea‑Level Rise on Current Real‑Estate Losses: A Housing Market Case Study in Miami‑Dade, Florida

Sea-Level Rise (SLR) Projections from the National Oceanic and Atmospheric Administration (NOAA) and the U.S. Army Corp of Engineers (USACE) indicate increasing, and imminent, risk to coastal communities from tidal flooding and hurricane storm surge. Building on recent research related to the potential demographic impacts of such changes (Hauer et al. 2016, in Nat Clim Chang 3:802–806, 2017; Neumann et al. 2015; Curtis and Schneider in Popul Environ 33:28–54, 2011), localized flooding projections in the Miami Beach area (Wdowinski et al. in Ocean Coast Manag 126:1–8, 2016) and projected economic losses associated with this rise in projected SLR (Fu et al. Ocean Coast Manag 133:11–17, 2016); this research investigates the accrued current cost, in terms of real-estate dollars lost, due to recurrent tidal flooding and projected increases of flooding in Miami-Dade County. Most directly related to this line of research, Keenan et al. (2018) have recently produced results indicating that Climate Gentrification is taking place in Miami, FL with higher elevations in flood prone areas appreciating at a higher rate. In that vein of thinking, we seek to answer a question posed by such research: What is the actual accrued loss to sea-level rise over the recent past? To answer this question, we replicate well-documented estimation methods by combining publicly available sea-level rise projections, tide gauge trends, and property lot elevation data to identify areas regularly at risk of flooding. Combining recent patterns of flooding inundation with future forecasts, we find that properties projected to be inundated with tidal flooding in 2032 have lost $3.08 each year on each square foot of living area, and properties near roads that will be inundated with tidal flooding in 2032 have lost$3.71 each year on each square foot of living area. These effects total over $465 million in lost real-estate market value between 2005 and 2016 in the Miami-Dade area

Black Holes in Bulgeless Galaxies: An XMM-Newton Investigation of NGC 3367 AND NGC 4536

The vast majority of optically identified active galactic nuclei (AGNs) in the local Universe reside in host galaxies with prominent bulges, supporting the hypothesis that black hole formation and growth is fundamentally connected to the build-up of galaxy bulges. However, recent mid-infrared spectroscopic studies with Spitzer of a sample of optically "normal" late-type galaxies reveal remarkably the presence of high-ionization [NeV] lines in several sources, providing strong evidence for AGNs in these galaxies. We present follow-up X-ray observations recently obtained with XMM-Newton of two such sources, the late-type optically normal galaxies NGC 3367 and NGC 4536. Both sources are detected in our observations. Detailed spectral analysis reveals that for both galaxies, the 2-10 keV emission is dominated by a power law with an X-ray luminosity in the L(sub 2- 10 keV) approximates 10(exp 39) - 10(exp 40) ergs/s range, consistent with low luminosity AGNs. While there is a possibility that X-ray binaries account for some fraction of the observed X-ray luminosity, we argue that this fraction is negligible. These observations therefore add to the growing evidence that the fraction of late-type galaxies hosting AGNs is significantly underestimated using optical observations alone. A comparison of the midinfrared [NeV] luminosity and the X-ray luminosities suggests the presence of an additional highly absorbed X-ray source in both galaxies, and that the black hole masses are in the range of 10(exp 5) - 10(exp 7) solar M for NGC 3367 and 10(exp 4) - (exp 10) solar M for NGC 453