Предварительная оценка энергоэффективности зданий в условиях резко континентального климата

Construction of energy-efficient buildings becomes a top priority for many countries. Yet certain obstacles in achieving internal environment comfort standards remain in regions with extreme continental climate. In addition to engineering and economic challenges, there exist design process issues since design data should closely correspond with resulting performance of the building. This paper focuses on accurate energy demand estimation during design stage. Two types of buildings designed for Ural-Siberian region of Russia and for Kazakhstan are examined: detached and medium-rise apartment buildings. Most influential factors are taken into consideration and general recommendations on improving energy efficiency using effective combination of structural and engineering solutions are given. Adaptation of design procedure in terms of extreme continental climate made by means of simplified but precise Passive House planning tool is demonstrated.Строительство энергоэффективных зданий является приоритетным направлением для многих стран. Однако в регионах с суровым климатом часто возникают проблемы достижения нормативных показателей комфорта внутренней среды. В идеале проектные значения потребностей в электроэнергии на отопление и кондиционирование здания должны точно соответствовать итоговым показателям. В этой статье рассматриваются методики точного прогнозирования энергопотребления на стадии проектирования. Исследовано два типа зданий, проектируемых для Урало-Сибирского региона России и Казахстана: индивидуальный дом и многоквартирный дом средней этажности. Даны рекомендации по снижению энергопотребления зданий путем эффективного сочетания конструктивных и инженерных решений. Показан учет основных факторов, влияющих на энергетический баланс зданий. На примере Пакета проектирования пассивного дома 2007 приведен пример адаптации упрощенной, но достаточно точной методики расчета к резко континентальным климатическим условиям

Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data

AbstractThe gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sabò et al., Nature. (2014) 511:488–492) and the R scripts used for their computational analysis

SIR-C/X-SAR data calibration and ground truth campaign over the NASA-CB1 test-site

During the Space Shuttle Endeavour mission in October 1994, a remote-sensing campaign was carried out with the objectives of both radiometric and polarimetric calibration and ground truth data acquisition of bare soils. This paper presents the results obtained in the experiment. Polarimetric cross-talk and channel imbalance values, as well as radiometric calibration parameters, have been found to be within the science requirements for SAR images. Regarding ground truth measurements, a wide spread in the height rms values and correlation lengths has been observed, which has motivated a critical revisiting of surface parameters descriptors

CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions

Palbociclib, ribociclib, and abemaciclib belong to the third generation of cyclin-dependent kinases inhibitors (CDKis), an established therapeutic class for advanced and metastatic breast cancer. Interindividual variability in the therapeutic response of CDKis has been reported and some individuals may experience increased and unexpected toxicity. This narrative review aims at identifying the factors potentially concurring at this variability for driving the most appropriate and tailored use of CDKis in the clinic. Specifically, concomitant medications, pharmacogenetic profile, and pathophysiological conditions could influence absorption, distribution, metabolism, and elimination pharmacokinetics. A personalized therapeutic approach taking into consideration all factors potentially contributing to an altered pharmacokinetic/pharmacodynamic profile could better drive safe and effective clinical use

INSPEcT: a computational tool to infer mRNA synthesis, processing and degradation dynamics from RNA- and 4sU-seq time course experiments.

Abstract Motivation: Cellular mRNA levels originate from the combined action of multiple regulatory processes, which can be recapitulated by the rates of pre-mRNA synthesis, pre-mRNA processing and mRNA degradation. Recent experimental and computational advances set the basis to study these intertwined levels of regulation. Nevertheless, software for the comprehensive quantification of RNA dynamics is still lacking. Results: INSPEcT is an R package for the integrative analysis of RNA- and 4sU-seq data to study the dynamics of transcriptional regulation. INSPEcT provides gene-level quantification of these rates, and a modeling framework to identify which of these regulatory processes are most likely to explain the observed mRNA and pre-mRNA concentrations. Software performance is tested on a synthetic dataset, instrumental to guide the choice of the modeling parameters and the experimental design. Availability and implementation: INSPEcT is submitted to Bioconductor and is currently available as Supplementary Additional File S1. Contact: [email protected] Supplementary Information: Supplementary data are available at Bioinformatics online

Utilização de xiloglucana na embriogênese somática a partir de embriões zigóticos de dendezeiro (Elaeis guineensis Jacq.).

O objetivo deste trabalho foi testar diferentes meios de cultura contendo misturas de XG e de Gelrite

Numerical Solution of Differential Equations by the Parker-Sochacki Method

A tutorial is presented which demonstrates the theory and usage of the Parker-Sochacki method of numerically solving systems of differential equations. Solutions are demonstrated for the case of projectile motion in air, and for the classical Newtonian N-body problem with mutual gravitational attraction.Comment: Added in July 2010: This tutorial has been posted since 1998 on a university web site, but has now been cited and praised in one or more refereed journals. I am therefore submitting it to the Cornell arXiv so that it may be read in response to its citations. See "Spiking neural network simulation: numerical integration with the Parker-Sochacki method:" J. Comput Neurosci, Robert D. Stewart & Wyeth Bair and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717378