Revised WMAP constraints on neutrino masses and other extensions of the minimal Λ\LambdaCDM model

Recently, two issues concerning the three-year WMAP likelihood code were pointed out. On large angular scales ($l \lesssim 30$), a sub-optimal likelihood approximation resulted in a small power excess. On small angular scales ($l \gtrsim 300$), over-subtraction of unresolved point sources produced a small power deficit. For a minimal six-parameter cosmological model, these two effects conspired to decrease the value of $n_s$ by $\sim 0.7 \sigma$. In this paper, we study the change in preferred parameter ranges for more extensive cosmological models, including running of $n_s$, massive neutrinos, curvature, and the equation of state for dark energy. We also include large-scale structure and supernova data in our analysis. We find that the parameter ranges for $\alpha_s$, $\Omega_k$ and $w$ are not much altered by the modified analysis. For massive neutrinos the upper limit on the sum of the neutrino masses decreases from $M_\nu < 1.90$eV to $M_\nu < 1.57$eV when using the modified WMAP code and WMAP data only. We also find that the shift of $n_s$ to higher values is quite robust to these extensions of the minimal cosmological model.Comment: 7 pages. Matching version published in Physical Review D. Figures changed, references added, additional comment

Brassica cover crops for weed control in organic vegetable production

Cover crops (or green manures) are commonly used by organic vegetable growers for soil fertility building and other benefits including weed control. Brassica crops have been reported to control weeds in subsequent crops, usually attributed to the allelopathic effects of glucosinolates (GSL) in the brassica residues, although the effects are inconsistent. New brassica varieties with high GSL levels (Brassica juncea cv. Fumus and Raphanus sativus cv. Weedcheck) were tested in combination with mechanical weed control and another locally grown forage crop (Lolium multiflorum cv. Conquest) for their effects on weed growth during the pre-crop phase and subsequent weed and lettuce growth during the in-crop phase. The cover crops and bare fallow controlled weeds effectively during the pre-crop phase, but did not affect weed and lettuce growth in the following in-crop phase. The cover crops provided better on-going weed control than the bare fallow. Reducing the delay between the pre- and in-crop phases from four weeks to one day did not affect weed and lettuce growth. Weed control was closely related to the amount of light reduction by the cover crops, while competition for nutrients and water appeared to be less important in weed suppression by the cover crops. The use of cover crops requires careful selection of appropriate varieties, attention to good cover crop husbandry (particularly establishment) and an awareness of prevailing weed seed bank levels

A Unification of Models of Tethered Satellites

In this paper, different conservative models of tethered satellites are related mathematically, and it is established in what limit they may provide useful insight into the underlying dynamics. An infinite dimensional model is linked to a finite dimensional model, the slack-spring model, through a conjecture on the singular perturbation of tether thickness. The slack-spring model is then naturally related to a billiard model in the limit of an inextensible spring. Next, the motion of a dumbbell model, which is lowest in the hierarchy of models, is identified within the motion of the billiard model through a theorem on the existence of invariant curves by exploiting Moser's twist map theorem. Finally, numerical computations provide insight into the dynamics of the billiard model

Reactor sterile neutrinos, dark energy and the age of the universe

There are indications that the neutrino oscillation data from reactor experiments and the LSND and MiniBooNE experiments show a preference for two sterile neutrino species, both with masses in the eV region. We show that this result has a significant impact on some important cosmological parameters. Specifically, we use a combination of CMB, LSS and SN1A data and show that the existence of two light, sterile neutrinos would rule out the cosmological constant as dark energy at 95% confidence level, and lower the expansion age of the universe to 12.58 \pm 0.26 Gyr.Comment: Accepted for publication in Astronomy & Astrophysics. References added and typos corrected. Added numerical values for w ranges and Delta chi^2. Minor extension of discussio

The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons

Background: Apoptosis plays a critical role during neuronal development and disease. Developing sympathetic neurons depend on nerve growth factor (NGF) for survival during the late embryonic and early postnatal period and die by apoptosis in its absence. The proapoptotic BH3-only protein Bim increases in level after NGF withdrawal and is required for NGF withdrawal-induced death. The regulation of Bim expression in neurons is complex and this study describes a new mechanism by which an NGF-activated signalling pathway regulates bim gene expression in sympathetic neurons.Results: We report that U0126, an inhibitor of the prosurvival MEK-ERK pathway, increases bim mRNA levels in sympathetic neurons in the presence of NGF. We find that this effect is independent of PI3-K-Akt and JNK-c-Jun signalling and is not mediated by the promoter, first exon or first intron of the bim gene. By performing 3' RACE and microinjection experiments with a new bim-LUC+3'UTR reporter construct, we show that U0126 increases bim expression via the bim 3' UTR. We demonstrate that this effect does not involve a change in bim mRNA stability and by using PD184352, a specific MEK1/2-ERK1/2 inhibitor, we show that this mechanism involves the MEK1/2-ERK1/2 pathway. Finally, we demonstrate that inhibition of MEK/ERK signalling independently reduces cell survival in NGF-treated sympathetic neurons.Conclusions: These results suggest that in sympathetic neurons, MEK-ERK signalling negatively regulates bim expression via the 3' UTR and that this regulation is likely to be at the level of transcription. This data provides further insight into the different mechanisms by which survival signalling pathways regulate bim expression in neurons

Transient limb ischemia induces remote ischemic preconditioning in vivo

Background-Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size.Methods and Results-Endothelial IR injury of the human forearm was induced by 20 minutes of upper limb ischemia (inflation of a blood pressure cuff to 200 mm Hg) followed by reperfusion. Remote preconditioning was induced by three 5-minute cycles of ischemia of the contralateral limb. Venous occlusion plethysmography was used to assess forearm blood flow in response to acetylcholine at baseline and 15 minutes after reperfusion. Experimental myocardial infarction was achieved by 40 minutes of balloon occlusion of the left anterior descending artery in 15-kg pigs. Remote preconditioning was induced by four 5-minute cycles of lower limb ischemia. Triphenyltetrazolium staining was used to assess the extent of myocardial infarction. In the human study, the response to acetylcholine was significantly attenuated in the control group after 15 minutes' reperfusion, but remote preconditioning prevented this reduction. Limb ischemia caused a significant reduction in the extent of myocardial infarction relative to the area at risk compared with control (26 +/- 9% versus 53 +/- 8%, P < 0.05).Conclusion-Remote ischemic preconditioning prevents IR-induced endothelial dysfunction in humans and reduces the extent of myocardial infarction in experimental animals. Transient limb ischemia is a simple preconditioning stimulus with important potential clinical applications

Agronomic and economic evaluation of weed management methods in organic herb and vegetable production systems

Weed management is reported to be a major constraint in organic agriculture. Organic growers also report a lack of information about non-chemical weed control. A series of field trials was conducted in lettuce (Lactuca sativa L.) and echinacea (Echinacea purpurea (L.) Moench) crops to evaluate a range of weed control methods commonly used in organic herb and vegetable production systems. The criteria for evaluating the methods were weed growth, crop yield and cost effectiveness. Hand weeding, tillage and organic mulches (hay and pelletised paper) were effective to very effective at suppressing weeds. In general, good weed suppression was correlated with good crop yields; however, crop yields were reduced by tillage and paper mulch. Deducting the cost of the weed control method from the gross crop value caused a greater re-ranking of the treatment performance in lettuce than in echinacea. This is partly due to the different growing season lengths and market prices of the two test crops. The most cost effective methods for managing weeds in lettuce were tillage and hand weeding. When weed competition is low, the unweeded control treatment was also cost effective. In echinacea, hand weeding and hay mulch were consistently the most cost effective methods for managing weeds

Cosmological implications of the KATRIN experiment

The upcoming Karlsruhe Tritium Neutrino (KATRIN) experiment will put unprecedented constraints on the absolute mass of the electron neutrino, \mnue. In this paper we investigate how this information on \mnue will affect our constraints on cosmological parameters. We consider two scenarios; one where \mnue=0 (i.e., no detection by KATRIN), and one where \mnue=0.3eV. We find that the constraints on \mnue from KATRIN will affect estimates of some important cosmological parameters significantly. For example, the significance of $n_s<1$ and the inferred value of $\Omega_\Lambda$ depend on the results from the KATRIN experiment.Comment: 13 page

Dynamical Dark Energy model parameters with or without massive neutrinos

We use WMAP5 and other cosmological data to constrain model parameters in quintessence cosmologies, focusing also on their shift when we allow for non-vanishing neutrino masses. The Ratra-Peebles (RP) and SUGRA potentials are used here, as examples of slowly or fastly varying state parameter w(a). Both potentials depend on an energy scale \Lambda. Here we confirm the results of previous analysis with WMAP3 data on the upper limits on \Lambda, which turn out to be rather small (down to ~10^{-9} in RP cosmologies and ~10^{-5} for SUGRA). Our constraints on \Lambda are not heavily affected by the inclusion of neutrino mass as a free parameter. On the contrary, when the neutrino mass degree of freedom is opened, significant shifts in the best-fit values of other parameters occur.Comment: 9 pages, 3 figures, submitted to JCA