Effects of exoplanetary gravity on human locomotor ability

At some point in the future, if mankind hopes to settle planets outside the Solar System, it will be crucial to determine the range of planetary conditions under which human beings could survive and function. In this article, we apply physical considerations to future exoplanetary biology to determine the limitations which gravity imposes on several systems governing the human body. Initially, we examine the ultimate limits at which the human skeleton breaks and muscles become unable to lift the body from the ground. We also produce a new model for the energetic expenditure of walking, by modelling the leg as an inverted pendulum. Both approaches conclude that, with rigorous training, humans could perform normal locomotion at gravity no higher than 4 $g_{\textrm{Earth}}$.Comment: 12 pages, 4 figures, to be published in The Physics Teache

The role of mentorship in protege performance

The role of mentorship on protege performance is a matter of importance to academic, business, and governmental organizations. While the benefits of mentorship for proteges, mentors and their organizations are apparent, the extent to which proteges mimic their mentors' career choices and acquire their mentorship skills is unclear. Here, we investigate one aspect of mentor emulation by studying mentorship fecundity---the number of proteges a mentor trains---with data from the Mathematics Genealogy Project, which tracks the mentorship record of thousands of mathematicians over several centuries. We demonstrate that fecundity among academic mathematicians is correlated with other measures of academic success. We also find that the average fecundity of mentors remains stable over 60 years of recorded mentorship. We further uncover three significant correlations in mentorship fecundity. First, mentors with small mentorship fecundity train proteges that go on to have a 37% larger than expected mentorship fecundity. Second, in the first third of their career, mentors with large fecundity train proteges that go on to have a 29% larger than expected fecundity. Finally, in the last third of their career, mentors with large fecundity train proteges that go on to have a 31% smaller than expected fecundity.Comment: 23 pages double-spaced, 4 figure

Scenarios as the basis for assessment of mitigation and adaptation

The possibilities and need for adaptation and mitigation depends on uncertain future developments with respect to socio-economic factors and the climate system. Scenarios are used to explore the impacts of different strategies under uncertainty. In this chapter, some scenarios are presented that are used in the ADAM project for this purpose. One scenario explores developments with no mitigation, and thus with high temperature increase and high reliance on adaptation (leading to 4oC increase by 2100 compared to pre-industrial levels). A second scenario explores an ambitious mitigation strategy (leading to 2oC increase by 2100 compared to pre-industrial levels). In the latter scenario, stringent mitigation strategies effectively reduces the risks of climate change, but based on uncertainties in the climate system a temperature increase of 3oC or more cannot be excluded. The analysis shows that, in many cases, adaptation and mitigation are not trade-offs but supplements. For example, the number of people exposed to increased water resource stress due to climate change can be substantially reduced in the mitigation scenario, but even then adaptation will be required for the remaining large numbers of people exposed to increased stress. Another example is sea level rise, for which adaptation is more cost-effective than mitigation, but mitigation can help reduce damages and the cost of adaptation. For agriculture, finally, only the scenario based on a combination of adaptation and mitigation is able to avoid serious climate change impacts

Scientific and Regulatory Policy Committee (SRPC) Review*: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment

Increased cell proliferation is a central key event in the mode of action for many non-genotoxic carcinogens, and quantitative cell proliferation data play an important role in the cancer risk assessment of many pharmaceutical and environmental compounds. Currently, there is limited unified information on assay standards, reference values, targeted applications, study design issues, and quality control considerations for proliferation data. Here, we review issues in measuring cell proliferation indices, considerations for targeted studies, and applications within current risk assessment frameworks. As the regulatory environment moves toward more prospective evaluations based on quantitative pathway-based models, standardiza- tion of proliferation assays will become an increasingly important part of cancer risk assessment. To help address this development, we also discuss the potential role for proliferation data as a component of alternative carcinogenicity testing models. This information should improve consistency of cell proliferation methods and increase efficiency of targeted testing strategies

The locomotor kinematics of Asian and African elephants: changes with speed and size

For centuries, elephant locomotion has been a contentious and confusing challenge for locomotion scientists to understand, not only because of technical difficulties but also because elephant locomotion is in some ways atypical of more familiar quadrupedal gaits. We analyzed the locomotor kinematics of over 2400 strides from 14 African and 48 Asian elephant individuals (body mass 116-4632 kg) freely moving over ground at a 17-fold range of speeds, from slow walking at 0.40 m s-1 to the fastest reliably recorded speed for elephants, 6.8 m s-1. These data reveal that African and Asian elephants have some subtle differences in how size-independent kinematic parameters change with speed. Although elephants use a lateral sequence footfall pattern, like many other quadrupeds, they maintain this footfall pattern at all speeds, shifting toward a 25% phase offset between limbs (singlefoot) as they increase speed. The duty factors of elephants are greater for the forelimbs than for the hindlimbs, so an aerial phase for the hindquarters is reached at slower speeds than for the forequarters. This aerial phase occurs at a Froude number of around 1, matching theoretical predictions. At faster speeds, stance and swing phase durations approach asymptotes, with the duty factor beginning to level off, concurrent with an increase in limb compliance that likely keeps peak forces relatively low. This increase of limb compliance is reflected by increased compression of the hindlimbs. Like other tetrapods, smaller elephants are relatively more athletic than larger ones, but still move very similarly to adults even at <500 kg. At any particular speed they adopt greater relative stride frequencies and relative stride lengths compared to larger elephants. This extends to near-maximal locomotor performance as well - smaller elephants reach greater Froude numbers and smaller duty factors, hence likely reach relatively greater peak loads on their limbs and produce this force more rapidly. A variety of lines of kinematic evidence support the inference that elephants change their mechanics near a Froude number of 1 (if not at slower speeds), at least to using more compliant limbs, if not spring-like whole-body kinetics. In some ways, elephants move similarly to many other quadrupeds, such as increasing speed mainly by increasing stride frequency (except at fast speeds), and they match scaling predictions for many stride parameters. The main difference from most other animals is that elephants never change their footfall pattern to a gait that uses a whole-body aerial phase. Our large dataset establishes what the normal kinematics of elephant locomotion are, and can also be applied to identify gait abnormalities that may signal musculoskeletal pathologies, a matter of great importance to keepers of captive elephants

Formality and informality in the summative assessment of motor vehicle apprentices: a case study

This article explores the interaction of formal and informal attributes of competence‐based assessment. Specifically, it presents evidence from a small qualitative case study of summative assessment practices for competence‐based qualifications within apprenticeships in the motor industry in England. The data are analysed through applying an adaptation of a framework for exploring the interplay of formality and informality in learning. This analysis reveals informal mentoring as a significant element which influences not only the process of assessment, but also its outcomes. We offer different possible interpretations of the data and their analysis, and conclude that, whichever interpretation is adopted, there appears to be a need for greater capacity‐building for assessors at a local level. This could acknowledge a more holistic role for assessors; recognise the importance of assessors’ informal practices in the formal retention and achievement of apprentices; and enhance awareness of inequalities that may be reinforced by both informal and formal attributes of assessment practices

Let\u27s Talk About How We Talk: Communication Agreements in the Library Workplace

Purpose: This chapter introduces a new tool, termed the Communication Agreement, for enhancing communication in the library workplace. The chapter defines the communication agreement, provides discussion questions for forming a communication agreement, provides examples of how communication agreements are beneficial to a diverse library workforce, and provides strategies to informally assess communication agreements’ effectiveness. Practical implications: Communication problems in diverse library workplaces can lead to, or exacerbate, conflict between employees. Generational, cross-cultural, gender, and other differences can lead to misunderstandings and conflict between employees. The communication agreement provides library managers with a tool to bridge differences in communication styles between employees, enable employees to engage in more effective communication, assist employees in developing better understandings and respect for colleagues of different backgrounds, and raise employees’ emotional intelligences. Originality/Value: Numerous resources and publications provide generalized approaches to communicating with others in a heterogeneous workplace or team, but the communication agreement provides a new approach for developing effective communication between people in a diverse library workplace. Limitations: The chapter lays out informal assessment strategies for the communication agreement, but formal assessment methods and metrics still need to be developed

The effects of adding mass to the legs on the energetics and biomechanics of walking.

. Purpose: The metabolic cost of walking increases when mass is added to the legs, but the effects of load magnitude and location on the energetics and biomechanics of walking are unclear. We hypothesized that with leg loading 1) net metabolic rate would be related to the moment of inertia of the leg (I leg ), 2) kinematics would be conserved, except for heavy foot loads, and 3) swing-phase sagittal-plane net muscle moments and swing-phase leg-muscle electromyography (EMG) would increase. Methods: Five adult males walked on a forcemeasuring treadmill at 1.25 mIs j1 with no load and with loads of 2 and 4 kg per foot and shank, 4 and 8 kg per thigh, and 4, 8, and 16 kg on the waist. We recorded metabolic rate and sagittal-plane kinematics and net muscle moments about the hip, knee, and ankle during the single-stance and swing phases, and EMG of key leg muscles. Results: Net metabolic rate during walking increased with load mass and more distal location and was correlated with I leg (r 2 = 0.43). Thigh loading was relatively inexpensive, helping to explain why the metabolic rate during walking is not strongly affected by body mass distribution. Kinematics, single-stance and swing-phase muscle moments, and EMG were similar while walking with no load or with waist, thigh, or shank loads. The increase in net metabolic rate with foot loading was associated with greater EMG of muscles that initiate leg swing and greater swing-phase muscle moments. Conclusions: Distal leg loads increase the metabolic rate required for swinging the leg. The increase in metabolic rate with more proximal loads may be attributable to a combination of supporting (via hip abduction muscles) and propagating the swing leg. Key Words: LOCOMOTION, LEG LOADING, ELECTROMYOGRAPHY, METABOLIC RATE, LOAD CARRIAGE R ecent studies suggest that the primary determinants of the net metabolic rate during walking are performing work to propel the center of mass forward, supporting body weight, and swinging the legs (10-12). Gottschall and Kram (10) estimate that leg swing can account for only about 10% of the net metabolic rate during human walking. Yet, when a modest mass is added to the shank or foot, the metabolic rate during walking increases dramatically (29). A biomechanical explanation for this increase in net metabolic rate during walking has not been clearly established. A better understanding of the relationship between lower-extremity loading and the energetics and biomechanics of walking has practical importance for the study of obesity as well as the design of lower-extremity body armor, prosthetic legs, and powered leg exoskeleton devices. For example, we may gain insight into the effects of increased leg mass, via obesity or body armor, on the net metabolic rate of walking. Also, designers of lowerextremity prosthetic and assistive devices (e.g., powered orthosis) may be able to better estimate how the mass of these devices will affect the energetics and biomechanics of walking. We may also improve our understanding of neuromuscular control strategies that are used during gait. Walking with an external load generally increases metabolic rate. At normal walking speeds, adding a moderate load via a backpack or around the body`s center of mass increases gross metabolic rate in direct proportion to the added mass (i.e., a 20% body weight load results in a 20% increase in metabolic rate) (13). When expressed as net metabolic rate (gross j standing) per kilogram of body mass, the increase is greater than proportional to the load. For example, when walking at 1.5 mIs j1 , Griffin et al. (12) report a 98% increase in net metabolic rate with a load of 50% of body mass. When mass is added to the extremities, metabolic rate increases disproportionately with load and is greater with more distal locations of the load (29). Rose et al. (26) have shown that adding just 2 kg to each foot increased the gross metabolic rate by 30%. Royer and Martin (28) report tha

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential. Weismann's prediction was derived by considering the role of natural selection in regulating the duration of an organism's life. For various reasons, Weismann's ideas on ageing fell into neglect following his death in 1914, and cytogerontology has only reappeared as a major research area following the demonstration by Hayflick and Moorhead in the early 1960s that diploid human fibroblasts are restricted to a finite number of divisions in vitro. In this review we give a detailed account of Weismann's theory, and we reveal that his ideas were both more extensive in their scope and more pertinent to current research than is generally recognised. We also appraise the progress which has been made over the past hundred years in investigating the causes of ageing, with particular emphasis being given to (i) the evolution of ageing, and (ii) ageing at the cellular level. We critically assess the current state of knowledge in these areas and recommend a series of points as primary targets for future research