Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression.

The Western diet contains a high ratio of omega-6 (ω6) to omega-3 (ω3) polyunsaturated fatty acids (PUFA). The prototypical aryl hydrocarbon receptor (AHR) ligand, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), induces CYP1 family enzymes, which can metabolize PUFA to epoxides. Mice fed ω3-rich or ω6-rich diets were treated with TCDD and injected subcutaneously with AHR-competent Hepa1-GFP hepatoma cells or AHR-deficient LLC lung cancer cells. TCDD reduced the growth rates of the resulting tumors in ω3-fed mice and inhibited their metastasis to the liver and/or lung, but had the opposite effects in mice fed ω6 PUFA. These responses were likely attributable to the corresponding PUFA epoxides generated in tumor cells and/or host, since many depended upon co-administration of a soluble epoxide hydrolase (EPHX2) inhibitor in males, and/or were associated with increases in epoxide levels in tumors and sites of metastasis. Equivalent effects occurred in females in the absence of EPHX2 inhibition, probably because this sex expressed reduced levels of EPHX2. The responses elicited by TCDD were associated with effects on tumor vascularity, tumor cell proliferation and/or apoptosis. Thus environmental AHR agonists, and potentially also endogenous, nutritional, and microbiome-derived agonists, may reduce or enhance cancer progression depending on the composition of dietary PUFA, particularly in females

Controlled epitaxial graphene growth within amorphous carbon corrals

Structured growth of high quality graphene is necessary for technological development of carbon based electronics. Specifically, control of the bunching and placement of surface steps under epitaxial graphene on SiC is an important consideration for graphene device production. We demonstrate lithographically patterned evaporated amorphous carbon corrals as a method to pin SiC surface steps. Evaporated amorphous carbon is an ideal step-flow barrier on SiC due to its chemical compatibility with graphene growth and its structural stability at high temperatures, as well as its patternability. The amorphous carbon is deposited in vacuum on SiC prior to graphene growth. In the graphene furnace at temperatures above 1200$^\circ$C, mobile SiC steps accumulate at these amorphous carbon barriers, forming an aligned step free region for graphene growth at temperatures above 1330$^\circ$C. AFM imaging and Raman spectroscopy support the formation of quality step-free graphene sheets grown on SiC with the step morphology aligned to the carbon grid

Ensin oli manipuljatsija, välissä news management ja lopulta suurta yleisöä vedettiin nenästä Miten välikielen kautta kääntäminen vaikuttaa viestin välittymiseen, tutkimus kotouttamisen ja vieraannuttamisen näkökulmasta

Tässä tutkimuksessa tarkastellaan välikielen kautta kääntämistä ja sen vaikutusta tekstin sisältämän viestin välittymiseen. Viestin välittymistä tarkastellaan kotouttavan ja vieraannuttavan käännösstrategian näkökulmasta. Kääntäminen on monikielistä viestintää, jossa liikutaan eri kielten ja kulttuurien välillä. Tässä tutkimuksessa kääntämisen prosessia verrataan yksinkertaistettuun viestinnän prosessiin ja löydetään niille yhtymäkohdat. Viestinnän kaaviosta muokataan omat versionsa kuvaamaan niin perinteistä käännösprosessia, jossa on mukana kaksi kieltä ja kulttuuria, kuin myös välikielen kautta kääntämisen prosessia, jolloin mukana on kolme kieltä ja kulttuuria. Tällöin on helppo huomata kuinka pitkän matkan viesti kulkee ennen kuin se päätyy alkuperäisen tekstin kirjoittajalta lopulliselle lukijalle. Tutkimuksen aineistona käytetään venäläisen toimittajan Anna Politkovskajan artikkeleita ja niiden käännöksiä englanniksi sekä pääasiassa englanninkielisten käännösten pohjalta tehtyjä suomenkielisiä käännöksiä. Käännöksistä tutkitaan erityisesti käännösprosessin aikana tehtyjä poistoja, lisäyksiä, leksikaalisia muutoksia ja rakenteen muutoksia. Tehtyjä muutoksia arvioidaan kotouttamisen ja vieraannuttamisen käännösstrategioiden näkökulmasta: kotouttamisen nähdään parantavan viestin välittymistä ja vieraannuttamisen heikentävän. Aineistossa havaittiin huomattavasti enemmän piirteitä kotouttavasta käännösstrategiasta, jolloin alkuperäisen viestin voisi ajatella välittyvän hyvin käännösten lukijoille. Kuitenkin aineistosta löytyi useita keinoja, joilla tekstistä oli tehty alkuperäistä tekstiä yksinkertaisempaa ja ilmaisultaan laimeampaa. Tämä viittaa siihen, ettei alkuperäisen tekstin viesti kuitenkaan välittynyt käännöksissä täydellisesti. Asiasanat:kotouttaminen, monikielinen viestintä, vieraannuttaminen, viestin välittyminen, välikielen kautta kääntämine

External perceptions of successful university brands

Branding in universities has become an increasingly topical issue, with some institutions committing substantial financial resources to branding activities. The particular characteristics of the sector present challenges for those seeking to build brands and it therefore seems to be timely and appropriate to investigate the common approaches of those institutions perceived as having successful brands. This study is exploratory in nature, seeking to investigate how successfully UK universities brand themselves, whether they are distinct and if the sector overall communicates effectively. This is approached through examining the perspective of opinion formers external to universities but closely involved with the sector – a key stakeholder group in UK higher education Overall, the research’s exploratory nature aims to further the debate on effective branding in UK higher education. The findings and conclusions identify some issues surrounding university branding activity; most UK universities were considered to be distinct from one another, but few were seen to have real fully formed brands. Although a number of institutions that were seen as having more ‘successful’ brands were identified, it was argued that whilst many UK universities communicate their brand well enough to key stakeholders, they fail to consistently do this across all audiences. It was also suggested that UK universities may concentrate on areas of perceived immediate strategic importance (in terms of branding) to an extent where others are neglected

The Oxford Common File Layout: A common approach to digital preservation

The Oxford Common File Layout describes a shared approach to filesystem layouts for institutional and preservation repositories, providing recommendations for how digital repository systems should structure and store files on disk or in object stores. The authors represent institutions where digital preservation practices have been established and proven over time or where significant work has been done to flesh out digital preservation practices. A community of practitioners is surfacing and is assessing successful preservation approaches designed to address a spectrum of use cases. With this context as a background, the Oxford Common File Layout (OCFL) will be described as the culmination of over two decades of experience with existing standards and practices

Supporting musicological investigations with information retrieval tools: an iterative approach to data collection

Digital musicology research often proceeds by extending and enriching its evidence base as it progresses, rather than starting with a complete corpus of data and metadata, as a consequence of an emergent research need. In this paper, we consider a research workflow which assumes an incremental approach to data gathering and annotation. We describe tooling which implements parts of this workflow, developed to support the study of nineteenth-century music arrangements, and evaluate the applicability of our approach through interviews with musicologists and music editors who have used the tools. We conclude by considering extensions of this approach and the wider implications for digital musicology and music information retrieval

Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study

Background: Moderate to severe premenstrual syndrome (PMS) affects 8–20 percent of premenopausal women. Previous studies suggest that high dietary vitamin D intake may reduce risk. However, vitamin D status is influenced by both dietary vitamin D intake and sunlight exposure and the association of vitamin D status with PMS remains unclear. Methods: We assessed the relation of plasma 25-hydroxyvitamin D (25OHD), total calcium and parathyroid hormone levels with risk of PMS and specific menstrual symptoms in a case–control study nested within the prospective Nurses’ Health Study II. Cases were 401 women free from PMS at baseline who developed PMS during follow-up (1991–2005). Controls were women not experiencing PMS (1991–2005), matched 1:1 with cases on age and other factors. Timed luteal phase blood samples were collected between 1996 and 1999 from cases and controls. We used conditional logistic regression to model the relation of 25OHD levels with risk of PMS and individual menstrual symptoms. Results: In analyses of all cases and controls, 25OHD levels were not associated with risk of PMS. However, results differed when the timing of blood collection vs. PMS diagnosis was considered. Among cases who had already been diagnosed with PMS at the time of blood collection (n = 279), 25OHD levels were positively associated with PMS, with each 10 nmol/L change in 25OHD associated with a 13% higher risk. Among cases who developed PMS after blood collection (n = 123), 25OHD levels were unrelated to risk of PMS overall, but inversely related to risk of specific menstrual symptoms. For example, each 10 nmol/L increase was associated with a significant 21% lower risk of breast tenderness (P = 0.02). Total calcium or parathyroid hormone levels were unrelated to PMS. Conclusions: 25OHD levels were not associated with overall risk of PMS. The positive association observed among women already experiencing PMS at the time of 25OHD measurement is likely due to confounding by indication related to use of dietary supplements to treat menstrual symptoms. Results from prospective analyses, which were less likely influenced by this bias, suggest that higher 25OHD levels may be inversely related to the development of specific menstrual symptoms

Heritage branding orientation: The case of Ach. Brito and the dynamics between corporate and product heritage brands

The notion of heritage branding orientation is introduced and explicated. Heritage branding orientation is designated as embracing both product and corporate brands and differs from corporate heritage brand orientation which has an explicit corporate focus. Empirical insights are drawn from an in-depth and longitudinal case study of Ach. Brito, a celebrated Portuguese manufacturer of soaps and toiletries. This study shows how, by the pursuance of a strategy derived from a heritage branding orientation Ach. Brito – after a prolonged period of decline – achieved a dramatic strategic turnaround. The findings reveal how institutional heritage can be a strategic resource via its adoption and activation at both the product and corporate levels. Moreover, the study showed how the bi-lateral interplay between product and corporate brand levels can be mutually reinforcing. In instrumental terms, the study shows how heritage can be activated and articulated in different ways. For instance, it can re-position both product and/or corporate brands; it can be meaningfully informed by product brand heritage and shape corporate heritage; and can be of strategic importance to both medium-sized and small enterprises

Risk prediction models with incomplete data with application to prediction of estrogen receptor-positive breast cancer: prospective data from the Nurses' Health Study

Introduction A number of breast cancer risk prediction models have been developed to provide insight into a woman\u27s individual breast cancer risk. Although circulating levels of estradiol in postmenopausal women predict subsequent breast cancer risk, whether the addition of estradiol levels adds significantly to a model\u27s predictive power has not previously been evaluated. Methods Using linear regression, the authors developed an imputed estradiol score using measured estradiol levels (the outcome) and both case status and risk factor data (for example, body mass index) from a nested case-control study conducted within a large prospective cohort study and used multiple imputation methods to develop an overall risk model including both risk factor data from the main cohort and estradiol levels from the nested case-control study. Results The authors evaluated the addition of imputed estradiol level to the previously published Rosner and Colditz log-incidence model for breast cancer risk prediction within the larger Nurses\u27 Health Study cohort. The follow-up was from 1980 to 2000; during this time, 1,559 invasive estrogen receptor-positive breast cancer cases were confirmed. The addition of imputed estradiol levels significantly improved risk prediction; the age-specific concordance statistic increased from 0.635 ± 0.007 to 0.645 ± 0.007 (P \u3c 0.001) after the addition of imputed estradiol. Conclusion Circulating estradiol levels in postmenopausal women appear to add to other lifestyle factors in predicting a woman\u27s individual risk of breast cancer