616 research outputs found
LISA data analysis: The monochromatic binary detection and initial guess problems
We consider the detection and initial guess problems for the LISA
gravitational wave detector. The detection problem is the problem of how to
determine if there is a signal present in instrumental data and how to identify
it. Because of the Doppler and plane-precession spreading of the spectral power
of the LISA signal, the usual power spectrum approach to detection will have
difficulty identifying sources. A better method must be found. The initial
guess problem involves how to generate {\it a priori} values for the parameters
of a parameter-estimation problem that are close enough to the final values for
a linear least-squares estimator to converge to the correct result. A useful
approach to simultaneously solving the detection and initial guess problems for
LISA is to divide the sky into many pixels and to demodulate the Doppler
spreading for each set of pixel coordinates. The demodulated power spectra may
then be searched for spectral features. We demonstrate that the procedure works
well as a first step in the search for gravitational waves from monochromatic
binaries.Comment: 8 pages, 8 figure
Probing anisotropies of gravitational-wave backgroundswith a space-based interferometer II: Perturbative reconstruction of a low-frequency skymap
We present a perturbative reconstruction method to make a skymap of
gravitational-wave backgrounds (GWBs) observed via space-based interferometer.
In the presence of anisotropies in GWBs, the cross-correlated signals of
observed GWBs are inherently time-dependent due to the non-stationarity of the
gravitational-wave detector. Since the cross-correlated signal is obtained
through an all-sky integral of primary signals convolving with the antenna
pattern function of gravitational-wave detectors, the non-stationarity of
cross-correlated signals, together with full knowledge of antenna pattern
functions, can be used to reconstruct an intensity map of the GWBs. Here, we
give two simple methods to reconstruct a skymap of GWBs based on the
perturbative expansion in low-frequency regime. The first one is based on
harmonic-Fourier representation of data streams and the second is based on
"direct" time-series data. The latter method enables us to create a skymap in a
direct manner. The reconstruction technique is demonstrated in the case of the
Galactic gravitational wave background observed via planned space
interferometer, LISA. Although the angular resolution of low-frequency skymap
is rather restricted, the methodology presented here would be helpful in
discriminating the GWBs of galactic origins by those of the extragalactic
and/or cosmological origins.Comment: 23 pages, 12 figures, Phys.Rev.D (2005) in pres
Low Frequency Gravitational Waves from White Dwarf MACHO Binaries
The possibility that Galactic halo MACHOs are white dwarfs has recently
attracted much attention. Using the known properties of white dwarf binaries in
the Galactic disk as a model, we estimate the possible contribution of halo
white dwarf binaries to the low-frequency (10^{-5} Hz} < f < 10^{-1}Hz)
gravitational wave background. Assuming the fraction of white dwarfs in
binaries is the same in the halo as in the disk, we find the confusion
background from halo white dwarf binaries could be five times stronger than the
expected contribution from Galactic disk binaries, dominating the response of
the proposed space based interferometer LISA. Low-frequency gravitational wave
observations will be the key to discovering the nature of the dark MACHO binary
population.Comment: 9 pages, 1 figure, AASTe
Elimination of Clock Jitter Noise in Spaceborn Laser Interferometers
Space gravitational wave detectors employing laser interferometry between
free-flying spacecraft differ in many ways from their laboratory counterparts.
Among these differences is the fact that, in space, the end-masses will be
moving relative to each other. This creates a problem by inducing a Doppler
shift between the incoming and outgoing frequencies. The resulting beat
frequency is so high that its phase cannot be read to sufficient accuracy when
referenced to state-of-the-art space-qualified clocks. This is the problem that
is addressed in this paper. We introduce a set of time-domain algorithms in
which the effects of clock jitter are exactly canceled. The method employs the
two-color laser approach that has been previously proposed, but avoids the
singularities that arise in the previous frequency-domain algorithms. In
addition, several practical aspects of the laser and clock noise cancellation
schemes are addressed.Comment: 20 pages, 5 figure
LISA Measurement of Gravitational Wave Background Anisotropy: Hexadecapole Moment via a Correlation Analysis
We discuss spatial fluctuations in the gravitational wave background arising
from unresolved Galactic binary sources, such as close white dwarf binaries,
due to the fact the galactic binary source distribution is anisotropic. We
introduce a correlation analysis of the two data streams of the Laser
Interferometer Space Antenna (LISA) to extract spherical harmonic coefficients,
in an independent manner, of the hexadecapole moment () related to the
projected two-dimensional density distribution of the binary source population.
The proposed technique complements and improves over previous suggestions in
the literature to measure the gravitational wave background anisotropy based on
the time modulation of data as LISA orbits around the Sun. Such techniques,
however, are restricted only to certain combinations of spherical harmonic
coefficients of the galaxy with no ability to separate them individually. With
LISA, and 4 coefficients of the hexadecapole () can be measured
with signal-to-noise ratios at the level of 10 and above in a certain
coordinate system. In addition to the hexadecapole coefficients, when combined
with the time modulation analysis, the correlation study can also be used, in
principle, to measure quadrupole coefficients of the binary distribution.Comment: 8 pages, 2 figure
Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab
Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone. Methods: K-RAS (exons 2, 3, 4) wild type colorectal cancer patients, candidates to second/third-line cetuximab with chemotherapy were prospectively allocated into 2 groups on the basis of their profile: favourable (BRAF and PIK3CA exon 20 wild type, EGFR GCN ≥ 2.6, HER-3 Rajkumar score ≤ 8, IGF-1 immunostaining < 2) or unfavourable (any of the previous markers altered or mutated). After the introduction of N-RAS status (exons 2, 3, 4) only RAS wild type patients were considered eligible. Results: Forty-six patients were enrolled. Seventeen patients (37%) were allocated to the favourable and 29 patients (63%) to the unfavourable profile. RR in the favourable and unfavourable group was 11/17 (65%) and 2/29 (7%) (p = 0.007) respectively. The favourable group also showed an improved PFS (8months vs. 3months, p < 0.0001) and OS (15months vs. 6months, p < 0.0001). Conclusions: Our results suggest that prospective selection of optimal candidates for cetuximab treatment is feasible and may be able to improve clinical outcom
Sensitivity curves for spaceborne gravitational wave interferometers
To determine whether particular sources of gravitational radiation will be
detectable by a specific gravitational wave detector, it is necessary to know
the sensitivity limits of the instrument. These instrumental sensitivities are
often depicted (after averaging over source position and polarization) by
graphing the minimal values of the gravitational wave amplitude detectable by
the instrument versus the frequency of the gravitational wave. This paper
describes in detail how to compute such a sensitivity curve given a set of
specifications for a spaceborne laser interferometer gravitational wave
observatory. Minor errors in the prior literature are corrected, and the first
(mostly) analytic calculation of the gravitational wave transfer function is
presented. Example sensitivity curve calculations are presented for the
proposed LISA interferometer. We find that previous treatments of LISA have
underestimated its sensitivity by a factor of .Comment: 27 pages + 5 figures, REVTeX, accepted for publication in Phys Rev D;
Update reflects referees comments, figure 3 clarified, figure 5 corrected for
LISA baselin
Mapping the gravitational wave background
The gravitational wave sky is expected to have isolated bright sources
superimposed on a diffuse gravitational wave background. The background
radiation has two components: a confusion limited background from unresolved
astrophysical sources; and a cosmological component formed during the birth of
the universe. A map of the gravitational wave background can be made by
sweeping a gravitational wave detector across the sky. The detector output is a
complicated convolution of the sky luminosity distribution, the detector
response function and the scan pattern. Here we study the general
de-convolution problem, and show how LIGO (Laser Interferometric Gravitational
Observatory) and LISA (Laser Interferometer Space Antenna) can be used to
detect anisotropies in the gravitational wave background.Comment: 16 pages, 6 figures. Submitted to CQ
A Markov Chain based method for generating long-range dependence
This paper describes a model for generating time series which exhibit the
statistical phenomenon known as long-range dependence (LRD). A Markov Modulated
Process based upon an infinite Markov chain is described. The work described is
motivated by applications in telecommunications where LRD is a known property
of time-series measured on the internet. The process can generate a time series
exhibiting LRD with known parameters and is particularly suitable for modelling
internet traffic since the time series is in terms of ones and zeros which can
be interpreted as data packets and inter-packet gaps. The method is extremely
simple computationally and analytically and could prove more tractable than
other methods described in the literatureComment: 8 pages, 2 figure
Angular Resolution of the LISA Gravitational Wave Detector
We calculate the angular resolution of the planned LISA detector, a
space-based laser interferometer for measuring low-frequency gravitational
waves from galactic and extragalactic sources. LISA is not a pointed
instrument; it is an all-sky monitor with a quadrupolar beam pattern. LISA will
measure simultaneously both polarization components of incoming gravitational
waves, so the data will consist of two time series. All physical properties of
the source, including its position, must be extracted from these time series.
LISA's angular resolution is therefore not a fixed quantity, but rather depends
on the type of signal and on how much other information must be extracted.
Information about the source position will be encoded in the measured signal in
three ways: 1) through the relative amplitudes and phases of the two
polarization components, 2) through the periodic Doppler shift imposed on the
signal by the detector's motion around the Sun, and 3) through the further
modulation of the signal caused by the detector's time-varying orientation. We
derive the basic formulae required to calculate the LISA's angular resolution
for a given source. We then evaluate for
two sources of particular interest: monchromatic sources and mergers of
supermassive black holes. For these two types of sources, we calculate (in the
high signal-to-noise approximation) the full variance-covariance matrix, which
gives the accuracy to which all source parameters can be measured. Since our
results on LISA's angular resolution depend mainly on gross features of the
detector geometry, orbit, and noise curve, we expect these results to be fairly
insensitive to modest changes in detector design that may occur between now and
launch. We also expect that our calculations could be easily modified to apply
to a modified design.Comment: 15 pages, 5 figures, RevTex 3.0 fil
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